UNSW Embryo- Development of the Endocrine System PubMed References Back to Endocrine Notes Links: PubMed Link About PubMed Note: A Selected List of References from PubMed March 1999 search results for head dev/review is available for computers within School of Anatomy without Internet access. Access to abstracts from these computers is not available. See also Review Articles Internet access computers will be able to get abstract directly from PubMed (when available) by clicking Author's name below.

Pituitary L1 and laminin: their expression during rat hypophysis ontogenesis and in adult neurohemal areas. Berardi M, Hindelang C, Felix JM, Stoeckel MEInt J Dev Neurosci 1999 Apr;17(2):121-30 L1 is a murine multidomain glycoprotein implicated in cell aggregation, fasciculation. neurite outgrowth and synaptogenesis. Laminin, a trimeric polypeptide, is implicated in neuronal survival, growth cone guidance, neurite outgrowth and cell differentiation. Laminin can also interact with the cell adhesion molecule L1. Their expressions were investigated from embryonic day 15 (E15) to adult in the rat hypophysis, and in adult neurohemal zones. Detected in the neural lobe from E17, the L1 immunoreactivity increased during prenatal development and persisted in adulthood mainly related to the neuropeptidergic fibers. Pituicytes were only labelled on the plasmalemma apposed to axons. In the intermediate lobe, L1 appeared at birth on folliculo-stellate cells extensions, constituting a network which densified during postnatal development. L1 is also expressed in all neurohemal areas on neuronal profiles. Laminin was clearly detectable in the hypophysis at E15 before the first blood vessels penetrate the Rathke pouch. At E20, all the basal membranes of the blood vessels were stained. In the intermediate lobe, a spotted laminin immunoreactivity was detected at E21. At this stage, we observed the staining of intercellular spaces and the intracellular labelling of melanotrophs, concerning reticulum or vesicles. The staining of melanotrophs seemed to maintain during adulthood. In contrast with blood vessels of the adult cerebral tissue, adult capillaries of the neural lobe and the others neuro-hemal zones were intensely labelled with the anti-laminin antibody. These results suggest that neurite outgrowth and neurite guidance could be promoted by L1 and laminin in the neurointermediate lobe. The "intercellular tunnels" could also be an important guidance cue for migrating cells in the intermediate lobe. These data also demonstrate that melanotrophic cells. secreting the laminin, have a role in the ontogenesis of the gland. Finally, we suggest that L1 and laminin can collaborate to reinforce "neurons-capillaries" interactions in neurohemal zones. PMID: 10221671, UI: 99236860

Thyroid The role of Hoxa-3 in mouse thymus and thyroid development. Manley NR, et al. Development. 1995 Jul;121(7):1989-2003. PMID: 7635047; UI: 95361754.