UNSW Embryo- Development of Left/Right AxisSelected References |
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PubMed
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Note: A Selected List of References for Left/Right Axis Development from PubMed August 1999. |
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Internet access computers will be able to get abstract directly from PubMed (when available) by clicking Author's name below. |
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Articles
- Differences in left-right axis pathways in mouse
and chick: functions of FGF8 and SHH. Meyers EN,
Martin GR Science 1999 Jul 16;285(5426):403-6 Abstract
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- chicken: Left = shh, Right = FGF8
- Mouse: Left = FGF8, Right= shh inhibition of FGF8 determinants
- The SIL gene is required for mouse embryonic axial
development and left-right specification. Izraeli S,
Lowe LA, Bertness VL, Good DJ, Dorward DW, Kirsch IR,
Kuehn MR Nature 1999 Jun 17;399(6737):691-4 Abstract
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- Here we show that mouse embryos lacking the early-response gene SIL have axial midline defects, a block in midline Sonic hedgehog (Shh) signalling and randomized cardiac looping. Comparison with Shh mutant embryos, which have axial defects but normal cardiac looping, indicates that the consequences of abnormal midline development for left-right patterning depend on the time of onset, duration and severity of disruption of the normal asymmetric patterns of expression of nodal, lefty-2 and Pitx2.
- SIL= early-response gene
- Regulation of left-right asymmetries in the
zebrafish by Shh and BMP4. Schilling TF, Concordet
JP, Ingham PW Dev Biol 1999 Jun 15;210(2):277-87
- show that Shh also specifies asymmetries in visceral precursors in the zebrafish and that cardiac and visceral sidedness are independent.
- The transcription factors fli-1 and Nkx-2.5 are expressed asymmetrically in the precardiac mesoderm and subsequently in the heart; an Eph receptor, rtk2, and an adhesion protein, DM-GRASP, mark early asymmetries in visceral endoderm.
- Misexpression of shh mRNA, or a dominant negative form of protein kinase A, on the right side reverses the expression of these asymmetries in precursors of both the heart and the viscera.
- Reversals in the heart and gut are uncoordinated, suggesting that each organ interprets the signal independently. Misexpression of Bone Morphogenetic Protein (BMP4) on the right side reverses the heart, but visceral organs are unaffected, consistent with a function for BMPs locally in the heart field. Zebrafish mutants with midline defects show independent reversals of cardiac and visceral laterality. Thus, hh signals influence the development of multiple organ asymmetries in zebrafish and different organs appear to respond to a central cascade of midline signaling independently, which in the heart involves BMP4.
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