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*600581 INHIBITOR OF DNA BINDING 4; ID4

table OF CONTENTS

 

Database Links

2 MEDLINE Citations 3 Protein Links 2 Nucleotide Links LocusLink Database Gene Map GDB Jackson Labs Mouse Database Nomenclature Database

Gene Map Locus: 6p22-p21.3

Note: pressing the Light Bulb symbol will find the citations in MEDLINE whose text most closely matches the text of the preceding OMIM paragraph, using the Entrez MEDLINE neighboring function.

 

TEXT

Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate the expression of tissue-specific genes in a number of mammalian and insect systems (Pagliuca et al., 1995). DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins (encoded by Id-related genes) also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins. Pagliuca et al. (1995) reported the cDNA sequence of a novel human HLH gene, to which the symbol ID4 was assigned, which lacks the basic domain. ID4 is differentially expressed in adult organs as 4 mRNA molecules that are presumably the result of differential splicing and/or alternative polyadenylation sites. Transfection experiments indicated that enforced expression of the ID4 protein inhibits the transactivation of the muscle creatine kinase (CKM; 123310) E-box enhancer by MyoD (MYOD1; 159970). 30 MEDLINE Neighbors

By fluorescence in situ hybridization (FISH), Pagliuca et al. (1995) mapped the ID4 gene to 6p22-p21.3. By the same method, Rigolet et al. (1998) mapped the gene to 6p23-p22.3.

For other dominant-negative inhibitors of DNA binding, see ID1 (600349), ID2 (600386), and ID3 (600277).


REFERENCES

1. Pagliuca, A.; Bartoli, P. C.; Saccone, S.; Valle, G. D.; Lania, L. :
Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22. Genomics 27: 200-203, 1995.
PubMed ID : 7665172

 

2. Rigolet, M.; Rich, T.; Gross-Morand, M.-S.; Molina-Gomes, D.; Viegas-Pequignot, E.; Junien, C. :

cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene. DNA Res. 5: 309-313, 1998.
PubMed ID :

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Date Last Modified: 11/3/99
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