142700 HIP, DISLOCATION OF, CONGENITAL
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titles; symbols
DISLOCATION OF HIP, CONGENITAL
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TEXT
The genetics is considered complex. Joint
laxity, normally greater in females than in males,
probably accounts for the preponderance of affected
females over males. Laxity of joints, often
familial (147900),
is probably a factor, especially in males. Hip
dysplasia with dislocation occurs in high frequency
in the German shepherd dog. Autosomal dominant
inheritance was favored by Bornfors
et al. (1964). Dislocation of the hip is an
occasional feature of conditions with simple
inheritance, e.g., Marfan syndrome and
Ehlers-Danlos syndrome. Record
and Edwards (1958) estimated the risk of
recurrence in subsequently born sibs to be about
5%. Congenital dislocation of the hip generally
behaves as a multifactorial trait. However,
Horton et al. (1979)
observed a kindred in which 16 males and 16 females
in 6 generations were affected. There were several
examples of male-to-male transmission. In 27 family
members hip dislocation was associated with joint
laxity. Five had joint laxity only. Six obligate
heterozygotes showed no abnormality. A classic
article by Perkins (1928)
on signs by which to diagnose congenital
dislocation of the hip was excerpted by Peltier
(1992).
-
SEE ALSO
- Carter and Wilkinson
(1964) ; Carter and
Wilkinson (1964) ; Fredensborg
and Uden (1976) ; Skirving
et al. (1984)
REFERENCES
- 1. Bornfors, S.;
Palsson, K.; Skude, G. :
- Hereditary aspects of hip dysplasia
in German shepherd dogs. J. Am.
Vet. Med. Assoc. 145: 15-20, 1964.
- 2. Carter, C. O.;
Wilkinson, J. A. :
- Genetic and environmental factors in
the etiology of congenital dislocation of the
hip. Clin. Orthop. 33:
119-128, 1964.
PubMed ID : 5889015
- 3. Carter, C. O.;
Wilkinson, J. A. :
- Persistent joint laxity and
congenital dislocation of the hip.
J. Bone Joint Surg. 46B: 40-45, 1964.
- 4. Fredensborg, N.;
Uden, A. :
- Altered connective tissue in
children with congenital dislocation of the
hip. Arch. Dis. Child. 51:
887-889, 1976.
PubMed ID : 1008597
- 5. Horton, W. A.;
Schimke, R. N.; Kennedy, J.; DeSmet, A. :
- Autosomal dominant inheritance of
congenital dislocation of the hip.
(Abstract) Am. J. Hum. Genet.
31: 74A only, 1979.
- 6. Peltier, L. F.
:
- The classic: signs by which to
diagnose congenital dislocation of the
hip. Clin. Orthop. Rel. Res.
274: 3-6, 1992.
- 7. Perkins, G.
:
- Signs by which to diagnose
congenital dislocation of the hip.
Lancet I: 648-650, 1928.
- 8. Record, R. G.;
Edwards, J. H. :
- Environmental influences related to
the etiology of congenital dislocation of the
hip. Brit. J. Prev. Soc. Med.
12: 8-22, 1958.
- 9. Skirving, A. P.;
Sims, T. J.; Bailey, A. J. :
- Congenital dislocation of the hip: a
possible inborn error of collagen
metabolism. J. Inherit. Metab.
Dis. 7: 27-31, 1984.
PubMed ID : 6429438
CLINICAL
SYNOPSIS
View
Clinical Synopsis Entry
CREATION DATE
Victor A. McKusick : 6/4/1986
EDIT HISTORY
mimadm : 9/24/1994
carol : 4/1/1992
supermim : 3/16/1992
carol : 2/26/1992
carol : 2/19/1992
supermim : 3/20/1990
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