UNSW Embryology
DEVELOPMENT OF THE URINARY SYSTEM	Embryology Home Page
EXSTROPHY OF BLADDER
Select Entry from OMIM Online Mendelian Inheritance in Man (Internet Link) This page is for computers without external internet access. Back to UNSW Embryology-Kidney Notes List of OMIM search results 600057 EXSTROPHY OF BLADDER table OF CONTENTS TEXT REFERENCES CREATION DATE EDIT HISTORY CLINICAL SYNOPSIS Database Links "1 MEDLINE Citation" Note: pressing the symbol will find the citations in MEDLINE whose text most closely matches the text of the preceding OMIM paragraph, using the Entrez MEDLINE neighboring function.   TEXT Exstrophy of the bladder results from abnormal development of the cloacal membrane. A midline closure defect develops, causing a failure of fusion of the entire lower anterior abdominal wall, including the symphysis pubis, lower urinary tract, and external genitalia. Messelink et al. (1994) found reports of 18 familial cases. These included 16 patients from 6 reported series comprising a total of 682 patients and 2 cases separately described by Glaser and Rossiter Lewis (1961). Messelink et al. (1994) described 2 affected cousins and affected parent and child. REFERENCES 1. Glaser, L. H.; Rossiter Lewis, A. P. : A case of familial incidence of ectopia vesicae. Brit. Med. J. 263: 1333 only, 1961.   2. Messelink, E. J.; Aronson, D. C.; Knuist, M.; Heij, H. A.; Vos, A. : Four cases of bladder exstrophy in two families. J. Med. Genet. 31: 490-492, 1994. PubMed ID : 8071977   CLINICAL SYNOPSIS View Clinical Synopsis Entry   CREATION DATE Victor A. McKusick : 7/26/1994 EDIT HISTORY mimadm : 9/23/1995 jason : 7/27/1994 jason : 7/26/1994 Back to UNSW Embryology-Kidney Notes

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