UNSW Embryology
DEVELOPMENT OF THE REPRODUCTIVE SYSTEM
OVARIAN GERM CELL CANCER
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603737 OVARIAN GERM CELL CANCERtable OF CONTENTSDatabase LinksThis MIM Record references no MEDLINE records.
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TEXTOvarian germ cell cancers are malignancies that
arise from germ cells of the embryonic gonad.
Although benign germ cell tumors are relatively
common, accounting for approximately 20% of all
ovarian neoplasms, malignant ovarian germ cell
tumors are rare. Weiss et al.
(1977) estimated that less than 5% of ovarian
cancers are of germ cell origin. Stettner
et al. (1999) found previous reports of 6
families in which more than 1 woman had a malignant
germ cell tumor, and presented an additional
ovarian germ cell cancer family in which a mother,
her daughter, and her niece were affected. The
affected niece was the offspring of the mother's
sister, who had breast cancer. A review of 8
patients with ovarian germ cell malignancies
identified 1 who had an uncle with testicular germ
cell cancer (see 273300).
Stettner et al. (1999)
tabulated 6 other instances of familial germ cell
malignancies in males and females.
REFERENCES
CREATION DATEVictor A. McKusick : 4/16/1999 EDIT HISTORYmgross : 4/20/1999 |
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