219050 CRYPTORCHIDISM, UNILATERAL OR
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Corbus and O'Conor
(1922) found several reports of families with
multiple generations affected. Perrett
and O'Rourke (1969) described ipsilateral
(right-sided) cryptorchidism in 8 males in 4
generations. Pardo-Mindan et
al. (1975) reported 2 families suggesting
autosomal dominant or, as they correctly indicated,
Y-linked inheritance. Bishop
et al. (1979) pointed out that renal anomalies
such as renal agenesis are often associated with
the familial form of cryptorchidism. Czeizel
et al. (1981) confirmed undescended testis in
1.5 to 4.0% of fathers and 6.2% of brothers. The
family clustering fitted a
Heritability in first-degree male relatives was
estimated to be 0.67 plus or minus 0.16. Bilateral
(more severe) cryptorchidism was associated with a
higher recurrence risk for brothers. The nosologic
identity of unilateral and bilateral cryptorchidism
was borne out by the study. Mothers of index cases
had shorter menses and delayed menarche; 'pituitary
hypogonadism of mothers seems to be a predisposing
factor for undescended testes in their sons.'
- 1. Bishop, M. C.;
Whitaker, R. H.; Sherwood, T. :
- Associated renal anomalies in
familial cryptorchidism. (Letter)
Lancet II: 249 only, 1979.
PubMed ID : 89356
- 2. Corbus, B. C.;
O'Conor, V. J. :
- The familial occurrence of
undescended testes. Report of six brothers with
testicular anomalies. Surg. Gynec.
Obstet. 34: 237-240, 1922.
- 3. Czeizel, A.;
Erodi, E.; Toth, J. :
- Genetics of undescended
testis. J. Urol. 126: 528-529,
PubMed ID : 6116809
- 4. Pardo-Mindan, F.
J.; Vargas Torcal, F.; Garcia Julian, F.; Virto
Ruiz, M. T. :
- Familial cryptorchidism.
(Letter) Pediatrics 56: 616
PubMed ID : 241049
- 5. Perrett, L. J.;
O'Rourke, D. A. :
- Hereditary cryptorchidism.
Med. J. Aust. 1: 1289-1290, 1969.
PubMed ID : 4389642
Clinical Synopsis Entry
Victor A. McKusick : 6/3/1986
mimadm : 2/19/1994
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/26/1989
marie : 3/25/1988
reenie : 6/3/1986