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The myotendinous junction (MTJ) is a specialiazed junction between a skeletal muscle and the tendon which transmit the force of the muscle contraction to the bone of the skeleton. Muscle contraction is transmitted to the skeleton, moving a bone. During development the MTJ has a unique microenvironment. Fibroblasts form the cellular component that produce large amounts of extra-cellular matrix. The extracellular matrix (ECM) secreted and deposited is high in collagen type I. The secreted extracellular matrix can also by altered by physical activity and mechanical loading. These changes are to collagen turnover, both synthesis and degradation, through metalloprotease enzymes (MMPs). |
Myotendinous Junction (Image: Blue Histology) |
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Page Links: Introduction | Some Recent Findings | Abnormalities | Histology | Histology Links | References | Glossary | Development Terms
Tozer S, Duprez D. Tendon and ligament: development, repair and disease. Birth Defects Res C Embryo Today. 2005 Sep;75(3):226-36.
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Tendons are a regular dense connective tissue with extracellular matrix fibres running parallel to each other. Fibroblasts form the cellular component that produce large amounts of extra-cellular matrix. The extracellular matrix secreted and deposited is high in collagen type I. Examples of regular dense connective tissue are: tendons, ligaments, fasciae and aponeuroses of muscles. (More? Histology Links) |
Myotendinous Junction (Image: Blue Histology) |
Links to related WWW sites with Histological images for Skeleton/ Muscle/ Connective Tissue system.
Note that all internet links change with time if link does not work use text shown to search WWW.
(Also see All systems)
Links: Journals | Online Textbooks | Reviews | Search PubMed | Glossary
Online Textbooks
Developmental Biology Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc. ; c2000 Forming the joints
GeneReviews Pagon, Roberta A., Editor-in-chief; Bird, Thomas C.; Dolan, Cynthia R.; Smith, Richard J.H.; Stephens, Karen; Associate editors. Seattle (WA): University of Washington ; c1993-2008 FGFR-Related Craniosynostosis Syndromes | Multiple Epiphyseal Dysplasia
Tozer S, Duprez D. Tendon and ligament: development, repair and disease. Birth Defects Res C Embryo Today. 2005 Sep;75(3):226-36.
Search July 2008 "Ligament Development" reference articles of which were reviews.
Search PubMed: term = Ligament Development | Tendon Development |
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The mesoderm forms nearly all the connective tissues of the musculoskeletal system. Each tissue (cartilage, bone, and muscle) goes through many different mechanisms of differentiation.
These note therefore have many different pages covering each of tissue, as well as information about limb development. Use the left hand menu to go to a specific topic of interest.
Please email Dr Mark Hill if you wish to make a comment about this current project.
