UNSW Embryology

Developmental Mechanism - Tube Formation

© Dr Mark Hill (2009)

Acknowledgements

Introduction

These note under development (notice removed when complete).

Throughout the body are many structures which are described as "tubular", that is they have a c ellular wall with a hollow often fluid-filled core.

Page Links: Introduction | Some Recent Findings | Reading | | Objectives | Reading | Development Overview | References | Search PubMed | Glossary | WWW Links

Some Recent Findings

Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formation Caroline Medioni, Martine Astier, Monika Zmojdzian, Krzysztof Jagla, and Michel Sémériva J. Cell Biol. 2008 182: 249-261.

"...we identify a genetic pathway in which roundabout, slit, held out wings, and dystroglycan control cardiac lumen formation by establishing nonadherent luminal membranes and regulating cell shape changes. From these data we propose a model for D. melanogaster cardiac lumen formation, which differs, both at a cellular and molecular level, from current models of epithelial tubulogenesis. We suggest that this new example of tube formation may be helpful in studying vertebrate heart tube formation and primary vasculogenesis."

Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin–mediated cell adhesion during Drosophila heart tube lumen formation Edgardo Santiago-Martínez, Nadine H. Soplop, Rajesh Patel, and Sunita G. Kramer J. Cell Biol. 2008 182: 241-248. [Abstract] [Full Text] [PDF]

"Our data show that Slit and Robo pathways function in lumen formation as a repulsive signal to antagonize E-Cad–mediated cell adhesion."

Gastrointestinal Tract

Roberts DJ, Smith DM, Goff DJ, Tabin CJ. Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development. 1998 Aug;125(15):2791-801.

Rubin DC. Intestinal morphogenesis. Curr Opin Gastroenterol. 2007 Mar;23(2):111-4.

Kidney

Yu J, McMahon AP, Valerius MT Recent genetic studies of mouse kidney development. Curr Opin Genet Dev. 2004 Oct;14(5):550-7.

Heart

Eurekah Bioscience Collection Chapters taken from the Eurekah Bioscience database. Eurekah.com and Landes Bioscience; 2003. Epithelial-Mesenchymal Transformation in the Embryonic Heart

Glands

Patel VN, Rebustini IT, Hoffman MP. Salivary gland branching morphogenesis. Differentiation. 2006 Sep;74(7):349-64.

Skin

Angel P, Szabowski A. Function of AP-1 target genes in mesenchymal-epithelial cross-talk in skin. Biochem Pharmacol. 2002 Sep;64(5-6):949-56.

References

Links: Journals | Online Textbooks | Search Textbooks | PubMed | Search PubMed | Glossary

Online Textbooks

Eurekah Bioscience Collection Chapters taken from the Eurekah Bioscience database. Eurekah.com and Landes Bioscience; 2003. Epithelial-Mesenchymal Transformation in the Embryonic Heart

Search NLM Online Textbooks- "Epithelial Mesenchymal Interaction" : Molecular Biology of the Cell | Molecular Cell Biology | The Cell- A molecular Approach

PubMed

Reviews

Airik R, Kispert A. Down the tube of obstructive nephropathies: the importance of tissue interactions during ureter development. Kidney Int. 2007 Dec;72(12):1459-67.

Wagner M, Siddiqui MA. Signal transduction in early heart development (I): cardiogenic induction and heart tube formation. Exp Biol Med (Maywood). 2007 Jul;232(7):852-65.

Articles

Roberts DJ, Smith DM, Goff DJ, Tabin CJ. Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development. 1998 Aug;125(15):2791-801.

Search PubMed

Search July 2008 "Embryonic Tube Formation" 3615 reference articles of which 289 were reviews.

Search PubMed: term = Tube Formation | Tube Formation | Heart Tube Formation |

WWW Links

Glossary of Terms

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

Quick Links

UNSW Embryology ISBN: 978 0 7334 2609 4

UNSW CRICOS Provider Code No. 00098G