Epithelial cells (organised cellular layer) and mesenchymal cells (embryonic connective tissue) or disorganised cellular layers interact together signaling back and forth by secreted signals or contact in the differentiation of many different organs, tissues and structures.
These embryological developmental mechanisms may also be recapitulated abnormally in the development of some diseases. (More? metastatic capabilities)
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Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, Kutok JL, Hartwell K, Richardson AL, Weinberg RA. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A. 2007 May 30;
"FOXC2 transcription factor, which is involved in specifying mesenchymal cell fate during embryogenesis, is associated with the metastatic capabilities of cancer cells. ...FOXC2 expression is induced in cells undergoing epithelial-mesenchymal transitions (EMTs) triggered by a number of signals, including TGF-beta1 and several EMT-inducing transcription factors, such as Snail, Twist, and Goosecoid."
Roberts DJ, Smith DM, Goff DJ, Tabin CJ. Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development. 1998 Aug;125(15):2791-801.
Rubin DC. Intestinal morphogenesis. Curr Opin Gastroenterol. 2007 Mar;23(2):111-4.
Yu J, McMahon AP, Valerius MT Recent genetic studies of mouse kidney development. Curr Opin Genet Dev. 2004 Oct;14(5):550-7.
Eurekah Bioscience Collection Chapters taken from the Eurekah Bioscience database. Eurekah.com and Landes Bioscience; 2003. Epithelial-Mesenchymal Transformation in the Embryonic Heart
Patel VN, Rebustini IT, Hoffman MP. Salivary gland branching morphogenesis. Differentiation. 2006 Sep;74(7):349-64.
Angel P, Szabowski A. Function of AP-1 target genes in mesenchymal-epithelial cross-talk in skin. Biochem Pharmacol. 2002 Sep;64(5-6):949-56.
Links: Journals | Online Textbooks | Search Textbooks | PubMed | Search PubMed | Glossary
Eurekah Bioscience Collection Chapters taken from the Eurekah Bioscience database. Eurekah.com and Landes Bioscience; 2003. Epithelial-Mesenchymal Transformation in the Embryonic Heart
Search NLM Online Textbooks- "Epithelial Mesenchymal Interaction" : Molecular Biology of the Cell | Molecular Cell Biology | The Cell- A molecular Approach
Reviews
Angel P, Szabowski A. Function of AP-1 target genes in mesenchymal-epithelial cross-talk in skin. Biochem Pharmacol. 2002 Sep;64(5-6):949-56.
Articles
Roberts DJ, Smith DM, Goff DJ, Tabin CJ. Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development. 1998 Aug;125(15):2791-801.
Search PubMed
Search April 2006 "Epithelial Mesenchymal Interaction" 78 reference articles of which 5 were reviews.
Search PubMed: term = Epithelial Mesenchymal Interaction | Epithelial Mesenchymal Transformation |
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Notes under development (notice removed when complete)
Cells organised as a layer (epithelia) and cells organised as a multilayer embryonic connective tissue (mesenchymal) signaling back and forth are the basis of development in many different tissues.
Developmental mechanisms is a new section of notes where I am trying to "group" some common types of pathways together.
Please email Dr Mark Hill if you wish to make a comment about this current project.