UNSW Embryology

Tomography Imaging Movies

© Dr Mark Hill (2008)

Acknowledgements

Introduction

Computed Tomography or computed axial tomography (CAT or CT scan) began in 1970's using x-ray and a computer to produce images either as individual slices or reconstructed to give three dimensional (3D) views of specific anatomical regions or structures.This page currently has links to x-ray micro-CT movies of early mouse development. (More? Mouse Development). Other potential developmental research imaging techniques include: positron emission tomography (PET), single photon emission computed tomography, magnetic resonance imaging, computed tomography, optical bioluminescence, fluorescence and high frequency ultrasound.

Micro-Computed Tomography Apparatus

Page Links: Introduction | Some Recent Findings | Mouse E12.5 Sagittal | Mouse E12.5 Coronal | Mouse E11.5 | About CT | CT Links | References | Glossary |

Some Recent Findings

Johnson JT, Hansen MS, Wu I, Healy LJ, Johnson CR, Jones GM, Capecchi MR, Keller C. Virtual histology of transgenic mouse embryos for high-throughput phenotyping. PLoS Genet. 2006 Apr;2(4):e61. (PLoS Link)

Mouse E12.5 Sagittal

Virtual Histology of Transgenic Mouse Embryos for High-Throughput Phenotyping Johnson JT, Hansen MS, Wu I, Healy LJ, Johnson CR, et al. PLoS Genetics Vol. 2, No. 4, e61 doi:10.1371/journal.pgen.0020061 Quicktime: Mouse E12.5 Sagittal Movie (3.6 Mb) (More? Mouse Development)

 

Mouse E12.5 Coronal

Virtual Histology of Transgenic Mouse Embryos for High-Throughput Phenotyping Johnson JT, Hansen MS, Wu I, Healy LJ, Johnson CR, et al. PLoS Genetics Vol. 2, No. 4, e61 doi:10.1371/journal.pgen.0020061 Quicktime: Mouse E12.5 Coronal Movie (5.1 Mb) (More? Mouse Development)

 

Mouse E12.5 Axial

Virtual Histology of Transgenic Mouse Embryos for High-Throughput Phenotyping Johnson JT, Hansen MS, Wu I, Healy LJ, Johnson CR, et al. PLoS Genetics Vol. 2, No. 4, e61 doi:10.1371/journal.pgen.0020061 Quicktime: Mouse E12.5 Axial Movie (4.5 Mb) (More? Mouse Development)

 

Mouse E11.5

Virtual Histology of Transgenic Mouse Embryos for High-Throughput Phenotyping Johnson JT, Hansen MS, Wu I, Healy LJ, Johnson CR, et al. PLoS Genetics Vol. 2, No. 4, e61 doi:10.1371/journal.pgen.0020061 Quicktime: Mouse E11.5 Movie (3.6 Mb) (More? Mouse Development)

 

About CT

Terms

CAT acronym for computed axial tomography.

CT acronym for computed tomography.

micro-CT acronym for micro-computed tomography.

CT Links

These links are to external sites with information about CT and require internet connection.

Siemens CT History and Technology PDF brochure giving background information on CT.

Multi-Dimensional Medical Imaging Studies at University College London

References

Reviews

Kalender WA. X-ray computed tomography. Phys Med Biol. 2006 Jul 7;51(13):R29-43.

Guldberg RE, Lin AS, Coleman R, Robertson G, Duvall C. Microcomputed tomography imaging of skeletal development and growth. Birth Defects Res C Embryo Today. 2004 Sep;72(3):250-9.

Lowe SA.

Diagnostic radiography in pregnancy: risks and reality. Aust N Z J Obstet Gynaecol. 2004 Jun;44(3):191-6.

Articles

Johnson JT, Hansen MS, Wu I, Healy LJ, Johnson CR, Jones GM, Capecchi MR, Keller C. Virtual histology of transgenic mouse embryos for high-throughput phenotyping. PLoS Genet. 2006 Apr;2(4):e61.

Pieles G, Geyer SH, Szumska D, Schneider J, Neubauer S, Clarke K, Dorfmeister K, Franklyn A, Brown SD, Bhattacharya S, Weninger WJ. microMRI-HREM pipeline for high-throughput, high-resolution phenotyping of murine embryos. J Anat. 2007 May 28;

Nieman BJ, Flenniken AM, Adamson SL, Henkelman RM, Sled JG. Anatomical phenotyping in the brain and skull of a mutant mouse by magnetic resonance imaging and computed tomography. Physiol Genomics. 2006 Jan 12;24(2):154-62.

Search PubMed

Search Jun 2007 "micro-CT" 482 reference articles of which 29 were reviews.

Search PubMed: term = micro-CT | embryo CT | embryonic CT scan | computer tomography |

Glossary of Terms

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

UNSW Embryology ISBN: 978 0 7334 2609 4

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