This page contains descriptions and links to embryonic zebrafish 48 hour postfertilization (hpf) heart movies showing the passage of blood through the living embryonic heart. The paper demonstrates in early development both blood flow and cardiac contractility influence the development of overall cardiac cell shape.
Original images and movie by : Auman HJ, Coleman H, Riley HE, Olale F, Tsai HJ, Yelon D. [See Related Articles] Functional Modulation of Cardiac Form through Regionally Confined Cell Shape Changes. PLoS Biol. 2007 Feb 20;5(3):e53
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Live wild-type 48-hpf embryo carrying Tg(cmlc2:egfp); expanded chamber stage, both chambers contract, Ventricle is to the left.
"Each expanded chamber ventricle (V) and atrium (A) assumes a bean-like morphology, featuring two distinctly curved surfaces: a greater, convex curvature called the outer curvature (OC) and a lesser, concave curvature called the inner curvature (IC)."
From: Functional Modulation of Cardiac Form through Regionally Confined Cell Shape Changes Auman HJ, Coleman H, Riley HE, Olale F, Tsai HJ, et al. PLoS Biology Vol. 5, No. 3, e53 doi:10.1371/journal.pbio.0050053
Quicktime: zheartsmall.mov (468 Kb)
PLoS External Link: Video S4. Wild-Type Embryo at 48 hpf Demonstrating Normal Cardiac Chamber Contractions(5.2 Mb) |
Heart link opens additional heart movies.
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Movies are Quicktime format that require Quicktime (a free downlaod) to be installed on your computer.
The heart is one of the earliest forming and functioning organs in the embryo, yet does not complete its development until postnatally with the functioning of the pulmonary (lung) system.
In humans, the transformation of a simple tube into a complex 4-chambered pump with 2 separate outflows is a complex process, and students often have difficulty understanding the latter parts of its development.
UNSW Embryology has many movies to show some of the dynamic changes that occur during embryonic development. These have been grouped together on separate pages (listed in righthand menu) that can be also be opened from a pull down menu on each page.
Internet users note that some of these movies are large and will take some time to download depending on your connection speed.
Both Mac and PC computers require the Quicktime plug-in to be present in your browser or on your computer.
CD users can find Quicktime on the CD or the latest version can be downloaded from here Quicktime
Please email Dr Mark Hill if you wish to make a comment about this current project.