This page contains movies and animations to illustrate various aspects of heart development.
There are 2 ways to watch each movie. Either click the image or text link to open a new page with both the movie and a more detailed text description of features that can be seen. Or the link below the images and text labelled Quicktime with the movie name and (file size) will open only the movie in a new window.
Page Links: Introduction | Early Embryonic Chick Heart | Mouse Heart | Heart Septation | Human Embryology Movies | Historic Heart Movies | WWW Links | Glossary
Heart Tube Looping
Realignment
Atrial Septation
Membranous Septation - Ventricular and Outflow
Links: Heart Looping | Realignment | Atrial Septation | Membranous Septation - Ventricular and Outflow | Large Version Heart Looping | Large Version Realignment
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Links: All Human Embryology Movies
Early embryonic chick heart page of movies showing the passage of blood through the living embryonic heart and also the importance of neural crest to the developing heart. This current movie is an edited version (looped and small) of the original movies by Dr ML Kirby, showing normal and abnormal heart development following neural crest ablation.
(see also paper: "Time-Lapse Study With High Speed Video Camera in the Early Embryonic Chick Heart to Visualize a Time Window of Normal and Abnormal Heart Development" in Circulation).
Link: Chicken Heart
Embryonic Zebrafish Heart page of movies showing the passage of blood through the living zebrafish (48hpf) embryonic heart. This current movie is an edited version (looped and small) of the original movie from Functional Modulation of Cardiac Form through Regionally Confined Cell Shape Changes Auman HJ, Coleman H, Riley HE, Olale F, Tsai HJ, et al. PLoS Biology Vol. 5, No. 3, e53 doi:10.1371/journal.pbio.0050053
Link: Zebrafish Heart
Three-Dimensional Analysis of Vascular Development in the Mouse Embryo Walls JR, Coultas L, Rossant J, Henkelman RM (2008) Three-Dimensional Analysis of Vascular Development in the Mouse Embryo. PLoS ONE 3(8): e2853.
Links: Mouse Heart | Vasculature Atlas of the Developing Mouse Embryo
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Showing the development of early heart ventricular septation. Quicktime: H1u.mov (748 Kb) |
Showing the membranous stage of ventricular septation. Quicktime: H2u.mov (680 Kb) |
Showing the closure of the ventricular septum. Quicktime: H3u.mov (672 Kb) |
Third movie of heart septation labelled. Closure- Third of 3 rotation movies showing the development of heart ventricular septation with labels on structures at this stage. Quicktime: H3l.mov (856 Kb)
The following movies are modified and converted from a historic animation (circa 1960's, copyright unknown) demonstrating aspects of human heart development. The sound quality is quite poor and some of the information is now out of date, most general concepts are still correct. Clicking on the image or text will open the movie in a new window, also please note the relatively large size (Mb) of each excerpt will effect download and viewing.
Quicktime: Early Heart 1 (4.8 Mb) |
Quicktime: Early Heart 2 (4.6 Mb) |
Quicktime: Mid Heart 1 (8.0 Mb) |
Quicktime: Mid Heart 2 (7.4 Mb) |
Quicktime: Mid Heart 3 (7.8 Mb) |
Quicktime: AtrialSeptum (5.6 Mb) |
Quicktime: AVcanals Ventricular Septum (3.5 Mb) |
Quicktime: Outflow Septum (7.1 Mb) |
Quicktime: Heart Valves (2.4 Mb) |
Quicktime: Whole Heart Movie (all the above segments, 50.7 Mb) |
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The heart is one of the earliest forming and functioning organs in the embryo, yet does not complete its development until postnatally with the functioning of the pulmonary (lung) system.
In humans, the transformation of a simple tube into a complex 4-chambered pump with 2 separate outflows is a complex process, and students often have difficulty understanding the latter parts of its development.
The models demonstrate ventricular septation and separation of the cardiac outflow (systemic/pulmonary).
The animations show cardiac tube folding, septation and the differences in fetal and postnatal circulation. UNSW Embryology has many movies to show some of the dynamic changes that occur during embryonic development. These have been grouped together on separate pages (listed in righthand menu) that can be also be opened from a pull down menu on each page.
Internet users note that some of these movies are large and will take some time to download depending on your connection speed.
Both Mac and PC computers require the Quicktime plug-in to be present in your browser or on your computer.
CD users can find Quicktime on the CD or the latest version can be downloaded from here Quicktime
Please email Dr Mark Hill if you wish to make a comment about this current project.
