Snail/slug are a family of zinc finger transcriptional repressors involved in regulation of epithelial–mesenchymal transitions in vertebrates. The factor 'snail' was first identified in Drosophila.
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Murray SA, Gridley T. Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A. 2006 Jun 26;
Developmental Biology (6th ed.) Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc. (c2000)
Molecular Biology of the Cell (4th ed.) Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter. New York: Garland Publishing (c2002)
The image below shows the regional location of the human SHH gene on chromosome 7 (7q36).
Signaling during development, though complex, can also be grouped into a few specific classes. These mechanisms have also been listed and described briefly on Signaling Mechanisms Introduction page.
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Reviews
Hemavathy K, Ashraf SI, Ip YT. Snail/slug family of repressors: slowly going into the fast lane of development and cancer. Gene. 2000 Oct 17;257(1):1-12.
Articles
Murray SA, Gridley T. Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A. 2006 Jun 26;
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Search Jul2006 "Snail/slug family of repressors" 2 reference articles.
Search PubMed: term = Snail/slug family of repressors
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This section of notes covers specific signaling factors involved in body patterns in multicellular organisms.
Molecular mechanisms of development is an exciting area and requires a variety of different skills. This page introduces only a few examples and should give you a feel for the topic.
Please email Dr Mark Hill if you wish to make a comment about this current project.