UNSW Embryology
Molecular Development- Retinoic Acid	Embryology Home Page
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Introduction Retinoic acid (RA) is a powerful morphogen, bound by a family of cytoplasmic RA receptors (RAR) which with bound RA translocate into the nucleus and bind DNA. This mechanism is similar to that seen with steroidal hormones and their receptors. The RAR has 3 domains: N-terminal, DNA-binding and C-terminal RA binding domain. These notes still under development.
Database Entry Links Genbank | Swiss-protein Human Genbank Entries LocusID Symbol Description Position Links 10425 ARI2 ariadne-2 (D. melanogaster) homolog (all-trans retinoic acid inducible RING finger )   1381 CRABP1 cellular retinoic acid-binding protein 1 15q24 1382 CRABP2 cellular retinoic acid-binding protein 2 1q21.3 4061 LY6E lymphocyte antigen 6 complex, locus E 8q24.3 10322 NN8-4AG retinoic acid responsive 2 10743 RAI1 retinoic acid induced 1 17p11.2 10742 RAI2 retinoic acid induced 2 Xp22 9052 RAI3 retinoic acid induced 3 12p13-p12.3 5914 RARA retinoic acid receptor, alpha 17q12 5915 RARB retinoic acid receptor, beta 3p24 5916 RARG retinoic acid receptor, gamma 12q13 5918 RARRES1 retinoic acid receptor responder (tazarotene induced) 1   5919 RARRES2 retinoic acid receptor responder (tazarotene induced) 2   5920 RARRES3 retinoic acid receptor responder (tazarotene induced) 3 11q23 6800 STRA13 stimulated by retinoic acid 13   9611 TRAC1 nuclear receptor co-repressor 1 11p11.2 7593 ZNF42 zinc finger protein 42 (myeloid-specific retinoic acid- responsive) 19q13.2-q13.4 Help Locus Link Help Page Link code PubMed OMIM RefSeq GenBank UniGene Variation top of page Swiss-Protein NiceProt View RETINOIC ACID RECEPTOR GAMMA-1 RETINOIC ACID RECEPTOR RXR-ALPHA
References Thaller C, et al.           [See Related Articles] Retinoid signaling in vertebrate limb development. Ann N Y Acad Sci. 1996 Jun 8;785:1-11. Review. No abstract available. PMID: 8702114; UI: 96280877.
Lecture Notes Please note that these notes only relate to the Anat 3311 Course. This section is not completely available, as I have been unable to transfer all my Lecture notes and research material in time for the deadline. This will be available in later versions. Early Development Lecture Simple pictures illustrating the early events of fertilization. Spinal Cord Development Figures and text relating to early events of spinal cord formation. Sex Determination Text relating to the molecular events of sex determination in the embryo. Polarity Concepts A short comparison of establishing positional information in embryos. Antennapedia The fly mutation that opened the field of Hox Genes and the conservation of pattern formation control mechanisms between species in embryonic development.
External WWW Search This current page has additional windows that allow searching of OMIM Morbid Map and OMIM Gene Map and access to other External WWW Search pages (Medical dictionaries, glossaries, chemicals and drugs). In the DNA Notes there is a window to search the Human Genome by keyword and also to search for a specific species classification. In the DNA Notes there is also a page with 3 search windows for Nucleotide Sequence, Protein Sequence and Biomolecule 3D Structure from NCBI. In the Chemical Notes there is a window to search a Material Safety Data Sheet database for a specific chemical and its associated hazard.
About Notes Notes from the Embryology Program compiled and written by Dr Mark Hill. This updated section of notes is still being developed Mar2000 and is not yet complete. Note that reference lists are only relevant to the date of the original search.	Links Serial Sections Homepage Human Homepage Pig Homepage
m.hill@unsw.edu.au Date Last Modified: 19/3/99 This site maintained by Dr M. Hill