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Introduction The bHLH transcription factor Olig2, together with its paralog Olig1, was first identified as a marker for oligodendrocyte progenitor cells (Lue et al., 2000; Zhou et generaal.,2000). Oligodendrocytes (OCs) are generated in the ventral neural tube well after the peak time of motorneuron (MN) genesis. A recent study has now shown another role for Oligo2 (see below). The bHLH repressor Olig2 participates in the transcriptional code governing cell fate specification in the ventral spinal cord. By temporally selective interactions with other transcription factors, Olig2 first directs motor neuron fate and later switches to promoting oligodendrocyte production. (text from ref below) Marquardt T. and Pfaff1, S.L., (2001) Gene Expression Laboratory Cracking the Transcriptional Code for Cell Specification in the Neural Tube Cell, Vol. 106, 651&endash;654
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References Marquardt T. and Pfaff1, S.L., (2001) Gene Expression Laboratory Cracking the Transcriptional Code for Cell Specification in the Neural Tube Cell, Vol. 106, 651&endash;654
Lecture Notes Please note that these notes only relate to the Anat 3311 Course. This section is not completely available, as I have been unable to transfer all my Lecture notes and research material in time for the deadline. This will be available in later versions. Early Development Lecture Simple pictures illustrating the early events of fertilization. Spinal Cord Development Figures and text relating to early events of spinal cord formation. Sex Determination Text relating to the molecular events of sex determination in the embryo. Polarity Concepts A short comparison of establishing positional information in embryos. Antennapedia The fly mutation that opened the field of Hox Genes and the conservation of pattern formation control mechanisms between species in embryonic development.
External WWW Search This current page has additional windows that allow searching of OMIM Morbid Map and OMIM Gene Map and access to other External WWW Search pages (Medical dictionaries, glossaries, chemicals and drugs). In the DNA Notes there is a window to search the Human Genome by keyword and also to search for a specific species classification. In the DNA Notes there is also a page with 3 search windows for Nucleotide Sequence, Protein Sequence and Biomolecule 3D Structure from NCBI. In the Chemical Notes there is a window to search a Material Safety Data Sheet database for a specific chemical and its associated hazard.
About Notes Notes from the Embryology Program compiled and written by Dr Mark Hill. This updated section of notes is still being developed Mar2000 and is not yet complete. Note that reference lists are only relevant to the date of the original search.	Links Serial Sections Homepage Human Homepage Pig Homepage
m.hill@unsw.edu.au Date Last Modified: 19/3/99 This site maintained by Dr M. Hill