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UNSW Embryology

Molecular Development- Nanog

© Dr Mark Hill (2006)

Acknowledgements

Introduction

A homeodomain-containing transcription factor involved in maintaining embryonic stem (ES) cell self-renewal. The name was derived from Celtic "Tir Na Nog" a mythologic Celtic land of the ever young.

Page Links: Introduction | Some Recent Findings | OMIM Entry Nanog | Bookshelf References | Signaling Factors | WWW Links | References | Glossary

Some Recent Findings

Suzuki A, Raya A, Kawakami Y, Morita M, Matsui T, Nakashima K, Gage FH, Rodriguez-Esteban C, Izpisua Belmonte JC. Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A. 2006 Jun 26;

OMIM Database

OMIM Online Database NANOG

Bookshelf References

Developmental Biology (6th ed.) Gilbert, Scott F. Sunderland (MA): Sinauer Associates, Inc. (c2000)

Image: Homology of process in the formation of the anterior-posterior axes in Drosophila and chick appendages

Image: The Hedgehog signal transduction pathway

Image: The Hedgehog signal transduction pathway

Molecular Biology of the Cell (4th ed.) Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter. New York: Garland Publishing (c2002)

Image: dorsoventral axis

Image: lung morphogenesis

Image: chick limb development

Image: limb patterning molecules

Human SHH Map

The image below shows the regional location of the human SHH gene on chromosome 7 (7q36).

Map 7q36

Signaling Factors

Signaling during development, though complex, can also be grouped into a few specific classes. These mechanisms have also been listed and described briefly on Signaling Mechanisms Introduction page.

References

Links: Journals | Online Textbooks | Search Textbooks | PubMed | Search PubMed | Glossary

Search NLM Online Textbooks snail : Molecular Biology of the Cell | Molecular Cell Biology | The Cell- A molecular Approach

PubMed

Reviews

Yates A, Chambers I. The homeodomain protein Nanog and pluripotency in mouse embryonic stem cells. Biochem Soc Trans. 2005 Dec;33(Pt 6):1518-21.

Cavaleri F, Scholer HR. Nanog: a new recruit to the embryonic stem cell orchestra. Cell. 2003 May 30;113(5):551-2.

Articles

Suzuki A, Raya A, Kawakami Y, Morita M, Matsui T, Nakashima K, Gage FH, Rodriguez-Esteban C, Izpisua Belmonte JC. Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A. 2006 Jun 26;

Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, Smith A. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell. 2003 May 30;113(5):643-55.

Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M, Yamanaka S. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003 May 30;113(5):631-42.

Hart AH, Hartley L, Ibrahim M, Robb L. Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. Dev Dyn. 2004 May;230(1):187-98.

Hatano SY, Tada M, Kimura H, Yamaguchi S, Kono T, Nakano T, Suemori H, Nakatsuji N, Tada T. Pluripotential competence of cells associated with Nanog activity. Mech Dev. 2005 Jan;122(1):67-79.

Rodda DJ, Chew JL, Lim LH, Loh YH, Wang B, Ng HH, Robson P. Related Articles, Links Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem. 2005 Jul 1;280(26):24731-7. Epub 2005 Apr 27. PMID: 15860457 [PubMed - indexed for MEDLINE]

Search PubMed

Search Jul2006 "Nanog" 134 reference articles of which 13 were reviews.

Search PubMed: term = Nanog

Glossary of Terms

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UNSW Embryology ISBN: 0 7334 2321 3

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