UNSW Embryology

Independent Learning Program - Heart Tutorial

© Dr Mark Hill (2010)

Acknowledgements

Introduction

This tutorial covers heart development including some of the major congenital abnormalities associated with the heart.

Use the links below to either view the Tutorial slides (1/page) or print (4/page).

Tutorial Slides

The links below are to PDF versions of lecture slides. Note that movies shown in tutorial will not run in these documents and are linked below.

Heart Science Lecture 2005 (1 slide/page)

Heart Science Lecture 2005 Handout (4 slides/page)

Lectopia Broadcast

Room M102 not equiped for Lectopia recording.

Quick Links

Notes - Cardiovascular System Development | Heart Abnormalities | Stage 13/14 | Stage 22 | Stage 22 Selected Highpower | Heart Rate | Molecular | Heart Movies | Postnatal

The Pediatric Cardiac Surgery Inquest Report, Province of Manitoba (Canada) Chapter 2 is a good general introduction to developmental heart abnormalities.

Heart Science Lecture 2005 | Heart Science Lecture 2005 Handout (slides as PDF document)

Heart Science Lecture 2004 (slides as PDF document)

Movie Links

Note that movies require quicktime to be installed on your computer.

All Movieslink takes you to the main movie resource page.

(More? All Human Embryology Movies)

Historic Heart Movies

The following movies are modified and converted from a historic animation (circa 1960's, copyright unknown) demonstrating aspects of human heart development. The sound quality is quite poor and some of the information is now out of date, most general concepts are still correct. Clicking on the image or text will open the movie in a new window, also please note the relatively large size (Mb) of each excerpt will effect download and viewing.

Whole Heart Movie (all the above segments, 50.7 Mb)

Heart Abnormalities

Atrial Septal Defects	Patent Ductus Arteriosus	Tetralogy of Fallot
Ventricular Septal Defect	Transposition of Great Vessels	Coarctation of Aorta
Hypoplastic Left Heart	Total Anomalous Pulmonary Venous Connection	Partial Anomalous Pulmonary Venous Drainage
Interrupted Aortic Arch	Double Outlet Right Ventricle	Tricuspid Atresia
Pulmonary Atresia	Aortic Stenosis	Pulmonary Stenosis

Normal and Abnormal Heart Comparison

Quicktime: heartloop180x120.mov (148 Kb) | abheartloop180x120.mov (96 Kb)

Removal (at Hamburger-Hamilton stage 14/15) of neural crest that normally contributes to the heart outflow generates heart abnormalities visible in this later embryo (stage 17) movie. Early abnormal cardiac looping can generate heart anomalies such as tetralogy of Fallot or double outlet right ventricle. This an edited extract version (looped and small) of the original full abnormal heart movie (Neuralcrestablatedheart.mov).

In the full movie of abnormal embryonic chicken heart, blood flow through the heart can be seen in a series of realtime samples of the embryo over an extended (10 hour) time period. The movie is a lateral view of the embryo (head and body) with the heart loop seen on the right and dorsal aorta on the left. In the neural crest-ablated embryo, the outflow limb is displaced ventrally/cranially and turned rightward so that both inflow and outflow limbs are visible from the right side.

Terms: Notes on tetralogy of Fallot

(More? Heart Movies- Early Embryonic Chick Heart)

Glossary of Terms

WWW Links

NCBI Medline Plus Congenital Heart Disease

National Heart, Lung and Blood Institue (USA) Congenital Heart Disease

Mayo Clinics Common types of congenital heart defects (online slideshow)

Province of Manitoba (Canada) The Pediatric Cardiac Surgery Inquest Report | Pediatric Cardiac Issues How the Heart Functions, Congenital Heart Defect and Their Treatment

American Heart Association Congenital Cardiovascular Defects

Quick Links

UNSW Embryology ISBN: 978 0 7334 2609 4

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