NiceProt View of SWISS-PROT: P35968

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	VGR2_HUMAN
Primary accession number	P35968
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 29, June 1994
Sequence was last modified in	Release 29, June 1994
Annotations were last modified in	Release 38, July 1999
Name and orig in of the protein
Protein name	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 [Precursor] [Fragment]
Synonym(s)	EC 2.7.1.112 VEGFR-2 KINASE INSERT DOMAIN RECEPTOR
Gene name(s)	KDR OR FLK1
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. TISSUE=UMBILICAL VEIN; MEDLINE; 92019839. [NCBI, ExPASy, Israel, Japan] Terman B.I., Carrion M.E., Kovacs E., Rasmussen B.A., Eddy R.L., Shows T.B.; "Identification of a new endothelial cell growth factor receptor tyrosine kinase."; Oncogene 6:1677-1683(1991).
[2] FUNCTION. MEDLINE; 93038639. [NCBI, ExPASy, Israel, Japan] Terman B.I., Dougher-Vermazen M., Carrion M.E., Dimitrov D., Armellino D.C., Gospodarowicz D., Boehlen P.; "Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor."; Biochem. Biophys. Res. Commun. 187:1579-1586(1992).
Comments
FUNCTION: RECEPTOR FOR VEGF OR VEGF-C. HAS A TYROSINE-PROTEIN KINASE ACTIVITY. THE VEGF-KINASE LIGAND/RECEPTOR SIGNALING SYSTEM PLAYS A KEY ROLE IN VASCULAR DEVELOPMENT AND REGULATION OF VASCULAR PERMEABILITY. SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN. SIMILARITY: BELONGS TO THE CSF-1/PDGF RECEPTOR FAMILY OF TYROSINE- PROTEIN KINASES. SIMILARITY: CONTAINS 7 IMMUNOGLOBULIN-LIKE DOMAINS.
Copyright
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Cross-references
EMBL X61656; CAA43837.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] L04947; AAA59459.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] HSSP P11362; 1AGW. [HSSP ENTRY / SWISS-3DIMAGE / PDB] MIM 191306; -. GeneCards KDR. PROSITE PS00107; PROTEIN_KINASE_ATP; FALSE_NEG. PS00109; PROTEIN_KINASE_TYR; 1. PS00240; RECEPTOR_TYR_KIN_III; 1. PS50011; PROTEIN_KINASE_DOM; 1. PFAM PF00047; ig; 6. PF00069; pkinase; 2. BLOCKS P35968. DOMO P35968. PROTOMAP P35968. PRESAGE P35968. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Signal; Transferase; Tyrosine-protein kinase; Receptor; Transmembrane; Glycoprotein; Phosphorylation; ATP-binding; Immunoglobulin domain.
Features
NON_TER 1 1 SIGNAL <1 17 POTENTIAL. CHAIN 18 1354 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2. DOMAIN 18 762 EXTRACELLULAR (POTENTIAL). TRANSMEM 763 787 POTENTIAL. DOMAIN 788 1354 CYTOPLASMIC (POTENTIAL). DOMAIN 44 108 IG-LIKE DOMAIN 1. DOMAIN 139 205 IG-LIKE DOMAIN 2. DOMAIN 237 312 IG-LIKE DOMAIN 3. DOMAIN 343 398 IG-LIKE DOMAIN 4. DOMAIN 436 535 IG-LIKE DOMAIN 5. DOMAIN 562 647 IG-LIKE DOMAIN 6. DOMAIN 679 742 IG-LIKE DOMAIN 7. DOMAIN 832 1160 PROTEIN KINASE. NP_BIND 838 846 ATP (BY SIMILARITY). BINDING 866 866 ATP (BY SIMILARITY). ACT_SITE 1026 1026 BY SIMILARITY. CARBOHYD 44 44 POTENTIAL. CARBOHYD 64 64 POTENTIAL. CARBOHYD 94 94 POTENTIAL. CARBOHYD 141 141 POTENTIAL. CARBOHYD 156 156 POTENTIAL. CARBOHYD 243 243 POTENTIAL. CARBOHYD 316 316 POTENTIAL. CARBOHYD 372 372 POTENTIAL. CARBOHYD 393 393 POTENTIAL. CARBOHYD 509 509 POTENTIAL. CARBOHYD 521 521 POTENTIAL. CARBOHYD 578 578 POTENTIAL. CARBOHYD 611 611 POTENTIAL. CARBOHYD 617 617 POTENTIAL. CARBOHYD 629 629 POTENTIAL. CARBOHYD 673 673 POTENTIAL. CARBOHYD 702 702 POTENTIAL. CARBOHYD 719 719 POTENTIAL. MOD_RES 1057 1057 PHOSPHORYLATION (AUTO-) (BY SIMILARITY). FT table viewer
Sequence information
Length: 1354 AA [This is the length of the unprocessed precursor / partial sequence] Molecular weight: 151227 Da [This is the Mw of the unprocessed precursor / partial sequence] CRC64: E445F66A889AF863 [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | SKVLLAVALW LCVETRAASV GLPSVSLDLP RLSIQKDILT IKANTTLQIT CRGQRDLDWL 70 80 90 100 110 120 | | | | | | WPNNQSGSEQ RVEVTECSDG LFCKTLTIPK VIGNDTGAYK CFYRETDLAS VIYVYVQDYR 130 140 150 160 170 180 | | | | | | SPFIASVSDQ HGVVYITENK NKTVVIPCLG SISNLNVSLC ARYPEKRFVP DGNRISWDSK 190 200 210 220 230 240 | | | | | | KGFTIPSYMI SYAGMVFCEA KINDESYQSI MYIVVVVGYR IYDVVLSPSH GIELSVGEKL 250 260 270 280 290 300 | | | | | | VLNCTARTEL NVGIDFNWEY PSSKHQHKKL VNRDLKTQSG SEMKKFLSTL TIDGVTRSDQ 310 320 330 340 350 360 | | | | | | GLYTCAASSG LMTKKNSTFV RVHEKPFVAF GSGMESLVEA TVGERVRIPA KYLGYPPPEI 370 380 390 400 410 420 | | | | | | KWYKNGIPLE SNHTIKAGHV LTIMEVSERD TGNYTVILTN PISKEKQSHV VSLVVYVPPQ 430 440 450 460 470 480 | | | | | | IGEKSLISPV DSYQYGTTQT LTCTVYAIPP PHHIHWYWQL EEECANEPSQ AVSVTNPYPC 490 500 510 520 530 540 | | | | | | EEWRSVEDFQ GGNKIEVNKN QFALIEGKNK TVSTLVIQAA NVSALYKCEA VNKVGRGERV 550 560 570 580 590 600 | | | | | | ISFHVTRGPE ITLQPDMQPT EQESVSLWCT ADRSTFENLT WYKLGPQPLP IHVGELPTPV 610 620 630 640 650 660 | | | | | | CKNLDTLWKL NATMFSNSTN DILIMELKNA SLQDQGDYVC LAQDRKTKKR HCVVRQLTVL 670 680 690 700 710 720 | | | | | | ERVAPTITGN LENQTTSIGE SIEVSCTASG NPPPQIMWFK DNETLVEDSG IVLKDGNRNL 730 740 750 760 770 780 | | | | | | TIRRVRKEDE GLYTCQACSV LGCAKVEAFF IIEGAQEKTN LEIIILVGTT VIAMFFWLLL 790 800 810 820 830 840 | | | | | | VIILGTVKRA NGGELKTGYL SIVMDPDELP LDEHCERLPY DASKWEFPRD RLNLGKPLGR 850 860 870 880 890 900 | | | | | | GAFGQEIEAD AFGIDKTATC RTVAVKMLKE GATHSEHRAL MSELKILIHI GHHLNVVNLL 910 920 930 940 950 960 | | | | | | GACTKPGGPL MVIVEFCKFG NLSTYLRSKR NEFVPYKTKG ARFRQGKDYV GAIPVDLKRR 970 980 990 1000 1010 1020 | | | | | | LDSITSSQSS ASSGFVEEKS LSDVEEEEAP EDLYKDFLTL EHLICYSFQV AKGMEFLASR 1030 1040 1050 1060 1070 1080 | | | | | | KCIHRDLAAR NILLSEKNVV KICDFGLARD IYKDPDYVRK GDARLPLKWM APETIFDRVY 1090 1100 1110 1120 1130 1140 | | | | | | TIQSDVWSFG VLLWEIFSLG ASPYPGVKID EEFCRRLKEG TRMRAPDYTT PEMYQTMLDC 1150 1160 1170 1180 1190 1200 | | | | | | WHGEPSQRPT FSELVEHLGN LLQANAQQDG KDYIVLPISE TLSMEEDSGL SLPTSPVSCM 1210 1220 1230 1240 1250 1260 | | | | | | EEEEVCDPKF HYDNTAGISQ YLQNSKRKSR PVSVKTFEDI PLEEPEVKVI PDDNQTDSGM 1270 1280 1290 1300 1310 1320 | | | | | | VLASEELKTL EDRTKLSPSF GGMVPSKSRE SVASEGSNQT SGYQSGYHSD DTDTTVYSSE 1330 1340 1350 | | | EAELLKLIEI GVQTGSTAQI LQPDTGTTLS SPPV P35968 in FASTA format