NiceProt View of SWISS-PROT: P70325

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	TBX4_MOUSE
Primary accession number	P70325
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 35, November 1997
Sequence was last modified in	Release 35, November 1997
Annotations were last modified in	Release 35, November 1997
Name and orig in of the protein
Protein name	TBX4 PROTEIN [Fragment]
Synonym(s)	T-BOX PROTEIN 4
Gene name(s)	TBX4
From	Mus musculus (Mouse)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.
References
[1] SEQUENCE FROM N.A. TISSUE=EMBRYO; MEDLINE; 97032942. [NCBI, ExPASy, Israel, Japan] Agulnik S.I., Garvey N., Hancock S., Ruvinsky I., Chapman D.L., Agulnik I., Bollag R.J., Papaioannou V.E., Silver L.M.; "Evolution of mouse T-box genes by tandem duplication and cluster dispersion."; Genetics 144:249-254(1996).
[2] DEVELOPMENTAL EXPRESSION. MEDLINE; 97006694. [NCBI, ExPASy, Israel, Japan] Chapman D.L., Garvey N., Hancock S., Alexiou M., Agulnik S.I., Gibson-Brown J.J., Cebra-Thomas J., Bollag R.J., Silver L.M., Papaioannou V.E.; "Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development."; Dev. Dyn. 206:379-390(1996).
Comments
FUNCTION: PROBABLE TRANSCRIPTIONAL REGULATOR INVOLVED IN DEVELOPMENTAL PROCESSES. SUBCELLULAR LOCATION: NUCLEAR (POTENTIAL). DEVELOPMENTAL STAGE: FIRST EXPRESSED AT DAY 7.5, EXCLUSIVELY IN THE ALLANTOIS WHERE EXPRESSION CONTINUES THROUGH DAY 8.5. AT DAY 9.5, EXPRESSION IS FOUND IN THE GENITAL PAPILLA, BODY WALL AND LIMB BUDS (HIGHER LEVELS IN HINDLIMB). AT DAY 12.5, EXPRESSED IN THE MESENCHYME OF THE MANDIBULAR ARCH, OF THE LUNG AND OF THAT SURROUNDING THE TRACHEA. ALSO FOUND IN THE SINUS VENOSUS/COMMON ATRIUM OF THE DEVELOPING HEART. SIMILARITY: CONTAINS A T-BOX DOMAIN.
Copyright
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Cross-references
EMBL U57329; AAC53108.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] HSSP P24781; 1XBR. [HSSP ENTRY / SWISS-3DIMAGE / PDB] MGD MGI:102556; TBX4. PROSITE PS01264; TBOX_2; 1. PS01283; TBOX_1; PARTIAL. PFAM PF00907; T-box; 1. BLOCKS P70325. DOMO P70325. PROTOMAP P70325. PRESAGE P70325. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Transcription regulation; DNA-binding; Nuclear protein.
Features
NON_TER 1 1 DNA_BIND <1 164 T-BOX. NON_TER 173 173 FT table viewer
Sequence information
Length: 173 AA [This is the length of the partial sequence] Molecular weight: 19790 Da [This is the Mw of the partial sequence] CRC64: 4A5238290E5B075D [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MIITKAGRRM FPSYKVKVTG MNPKTKYILL IDIVPADDHR YKFCDNKWMV AGKAEPMPGR 70 80 90 100 110 120 | | | | | | LYVHPDSPAT GAHWMRQLVS FQKLKLTNNH LDPFGHIILN SMHKYQPRLH IVKADENNAF 130 140 150 160 170 | | | | | GSKNTAFCTH VFPETSFISV TSYQNHKITQ LKIENNPFAK GFRGSDDSDL RVA P70325 in FASTA format