NiceProt View of SWISS-PROT: Q13207

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	TBX2_HUMAN
Primary accession number	Q13207
Secondary accession number(s)	Q16424
Entered in SWISS-PROT in	Release 35, November 1997
Sequence was last modified in	Release 35, November 1997
Annotations were last modified in	Release 38, July 1999
Name and orig in of the protein
Protein name	TBX2 PROTEIN
Synonym(s)	T-BOX PROTEIN 2
Gene name(s)	TBX2
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. TISSUE=FETAL KIDNEY; MEDLINE; 96015055. [NCBI, ExPASy, Israel, Japan] Campbell C., Goodrich K., Casey G., Beatty B.; "Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene."; Genomics 28:255-260(1995).
[2] SEQUENCE OF 152-245 FROM N.A. TISSUE=FETAL KIDNEY; MEDLINE; 96169568. [NCBI, ExPASy, Israel, Japan] Law D.J., Gebuhr T., Garvey N., Agulnik S.I., Silver L.M.; "Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family."; Mamm. Genome 6:793-797(1995).
Comments
FUNCTION: INVOLVED IN THE TRANSCRIPTIONAL REGULATION OF GENES REQUIRED FOR MESODERM DIFFERENTIATION. SUBCELLULAR LOCATION: NUCLEAR (POTENTIAL). TISSUE SPECIFICITY: EXPRESSED PRIMARILY IN ADULT IN KIDNEY, LUNG, AND PLACENTA. WEAK EXPRESSION IN HEART AND OVARY. SIMILARITY: CONTAINS A T-BOX DOMAIN.
Copyright
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Cross-references
EMBL U28049; AAA73861.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] S81264; AAB36216.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] HSSP P24781; 1XBR. [HSSP ENTRY / SWISS-3DIMAGE / PDB] MIM 600747; -. GeneCards TBX2. PRINTS PR00937; TBOX. PROSITE PS01264; TBOX_2; 1. PS01283; TBOX_1; 1. PFAM PF00907; T-box; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS Q13207. DOMO Q13207. PROTOMAP Q13207. PRESAGE Q13207. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Transcription regulation; DNA-binding; Nuclear protein.
Features
DOMAIN 48 63 POLY-ALA. DNA_BIND 104 277 T-BOX. DOMAIN 507 517 POLY-GLY. DOMAIN 571 579 POLY-ALA. DOMAIN 585 593 POLY-ALA. CONFLICT 155 155 Y -> D (IN REF. 2). CONFLICT 165 168 AGKA -> TDKT (IN REF. 2). FT table viewer
Sequence information
Length: 702 AA Molecular weight: 74194 Da CRC64: C6477134C69D7C2C [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALAK PLPDPGLAGA AAAAAAAAAA 70 80 90 100 110 120 | | | | | | AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE VEDDPKVTLE AKELWDQFHK LGTEMVITKS 130 140 150 160 170 180 | | | | | | GRRMFPPFKV RVSGLDKKAK YILLMDIVAA DDCRYKFHNS RWMVAGKADP EMPKRMYIHP 190 200 210 220 230 240 | | | | | | DSPATGEQWM AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF 250 260 270 280 290 300 | | | | | | RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT LPSLRLYEEH 310 320 330 340 350 360 | | | | | | CKPERDGAES DASSCDPPPA REPPTSPGAA PSPLRLHRAR AEEKSCAADS DPEPERLSEE 370 380 390 400 410 420 | | | | | | RARAPLGRSP APDSASPTRL TEPERARERR CPERGKEPAE SGGDGPFGLR SLEKERPEAR 430 440 450 460 470 480 | | | | | | RKDEGRKEAA EGKEQGLAPL VVQTDSASPL GAGHLPGLAF SSHLHGQQFF GPLGAGQPLF 490 500 510 520 530 540 | | | | | | LHPGQFTMGP GAFSAMGMGH LLASVAGGGN GGGGGPGTAA GLDAGGLGPA ASAASTAAPF 550 560 570 580 590 600 | | | | | | PFHLSQHMLA SQGIPMPTFG GLFPYPYTYM AAAAAAASAL PATSAAAAAA AAAGSLSRSP 610 620 630 640 650 660 | | | | | | FLGSARPRLR FSPYQIPVTI PPSTSLLTTG LASEGSKAAG GNSREPSPLP ELALRKVGAP 670 680 690 700 | | | | SRGALSPSGS AKEAANELLS IQRLVSGLES QRALSPGRES PK Q13207 in FASTA format