NiceProt View of SWISS-PROT: P19793

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	RXRA_HUMAN
Primary accession number	P19793
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 17, February 1991
Sequence was last modified in	Release 17, February 1991
Annotations were last modified in	Release 38, July 1999
Name and orig in of the protein
Protein name	RETINOIC ACID RECEPTOR RXR-ALPHA
Synonym(s)	None
Gene name(s)	RXRA OR NR2B1
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. TISSUE=KIDNEY; MEDLINE; 90238542. [NCBI, ExPASy, Israel, Japan] Manglesdorf D.J., Ong E.S., Dyck J.A., Evans R.M.; "Nuclear receptor that identifies a novel retinoic acid response pathway."; Nature 345:224-229(1990).
[2] LIGAND. MEDLINE; 92127596. [NCBI, ExPASy, Israel, Japan] Heyman R.A., Mangelsdorf D.J., Dyck J.A., Stein R.B., Eichele G., Evans R.M., Thaller C.; "9-cis retinoic acid is a high affinity ligand for the retinoid X receptor."; Cell 68:397-406(1992).
[3] X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 130-209. MEDLINE; 95265100. [NCBI, ExPASy, Israel, Japan] Rastinejad F., Perlmann T., Evans R.M., Sigler P.B.; "Structural determinants of nuclear receptor assembly on DNA direct repeats."; Nature 375:203-211(1995).
[4] X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 225-462. MEDLINE; 95281048. [NCBI, ExPASy, Israel, Japan] Bourguet W., Ruff M., Chambon P., Gronemeyer H., Moras D.; "Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha."; Nature 375:377-382(1995).
[5] STRUCTURE BY NMR OF 130-212. MEDLINE; 98365498. [NCBI, ExPASy, Israel, Japan] Holmbeck S.M., Foster M.P., Casimiro D.R., Sem D.S., Dyson H.J., Wright P.E.; "High-resolution solution structure of the retinoid X receptor DNA- binding domain."; J. Mol. Biol. 281:271-284(1998).
Comments
FUNCTION: INVOLVED IN RETINOIC ACID RESPONSE PATHWAY. BINDS 9-CIS RETINOIC ACID (9C-RA). SUBUNIT: HOMODIMER OR HETERODIMER. SUBCELLULAR LOCATION: NUCLEAR. TISSUE SPECIFICITY: HIGHLY EXPRESSED IN LIVER, ALSO FOUND IN LUNG, KIDNEY AND HEART. DOMAIN: COMPOSED OF THREE DOMAINS: A MODULATING N-TERMINAL DOMAIN, A DNA-BINDING DOMAIN AND A C-TERMINAL STEROID-BINDING DOMAIN. SIMILARITY: BELONGS TO THE NUCLEAR HORMONE RECEPTORS FAMILY. NR2 SUBFAMILY.
Copyright
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Cross-references
EMBL X52773; CAA36982.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] PIR S09592; S09592. PDB 2NLL; 12-MAR-97. [ExPASy / RCSB] 1LBD; 08-NOV-96. [ExPASy / RCSB] 1RXR; 11-NOV-98. [ExPASy / RCSB] SWISS-3DIMAGE RXRA_HUMAN. MIM 180245; -. GeneCards RXRA. PRINTS PR00047; STROIDFINGER. PR00545; RETINOIDR. PROSITE PS00031; NUCLEAR_RECEPTOR; 1. PFAM PF00104; hormone_rec; 1. PF00105; zf-C4; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS P19793. DOMO P19793. PROTOMAP P19793. PRESAGE P19793. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Receptor; Transcription regulation; DNA-binding; Nuclear protein; Zinc-finger; Multigene family; 3D-structure.
Features
DOMAIN 1 134 MODULATING (BY SIMILARITY). DNA_BIND 135 200 C4-TYPE ZINC FINGERS (TWO). ZN_FING 135 155 C4-TYPE. ZN_FING 171 195 C4-TYPE. DOMAIN 201 224 HINGE. DOMAIN 225 462 LIGAND-BINDING. FT table viewer
Sequence information
Length: 462 AA Molecular weight: 50811 Da CRC64: 7F952B580AD84C42 [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MDTKHFLPLD FSTQVNSSLT SPTGRGSMAA PSLHPSLGPG IGSPGQLHSP ISTLSSPING 70 80 90 100 110 120 | | | | | | MGPPFSVISS PMGPHSMSVP TTPTLGFSTG SPQLSSPMNP VSSSEDIKPP LGLNGVLKVP 130 140 150 160 170 180 | | | | | | AHPSGNMASF TKHICAICGD RSSGKHYGVY SCEGCKGFFK RTVRKDLTYT CRDNKDCLID 190 200 210 220 230 240 | | | | | | KRQRNRCQYC RYQKCLAMGM KREAVQEERQ RGKDRNENEV ESTSSANEDM PVERILEAEL 250 260 270 280 290 300 | | | | | | AVEPKTETYV EANMGLNPSS PNDPVTNICQ AADKQLFTLV EWAKRIPHFS ELPLDDQVIL 310 320 330 340 350 360 | | | | | | LRAGWNELLI ASFSHRSIAV KDGILLATGL HVHRNSAHSA GVGAIFDRVL TELVSKMRDM 370 380 390 400 410 420 | | | | | | QMDKTELGCL RAIVLFNPDS KGLSNPAEVE ALREKVYASL EAYCKHKYPE QPGRFAKLLL 430 440 450 460 | | | | RLPALRSIGL KCLEHLFFFK LIGDTPIDTF LMEMLEAPHQ MT P19793 in FASTA format