NiceProt View of SWISS-PROT: P13631

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	RRG1_HUMAN
Primary accession number	P13631
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 13, January 1990
Sequence was last modified in	Release 13, January 1990
Annotations were last modified in	Release 38, July 1999
Name and orig in of the protein
Protein name	RETINOIC ACID RECEPTOR GAMMA-1
Synonym(s)	RAR-GAMMA-1
Gene name(s)	RARG OR NR1B3
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. MEDLINE; 89315787. [NCBI, ExPASy, Israel, Japan] Krust A., Kastner P., Petkovich M., Zelent A., Chambon P.; "A third human retinoic acid receptor, hRAR-gamma."; Proc. Natl. Acad. Sci. U.S.A. 86:5310-5314(1989).
[2] SEQUENCE FROM N.A. MEDLINE; 91042616. [NCBI, ExPASy, Israel, Japan] Ishikawa T., Umesono K., Mangelsdorf D.J., Aburatani H., Stanger B.Z., Shibasaki Y., Imawari M., Evans R.M., Takaku F.; "A functional retinoic acid receptor encoded by the gene on human chromosome 12."; Mol. Endocrinol. 4:837-844(1990).
[3] SEQUENCE FROM N.A. MEDLINE; 91187677. [NCBI, ExPASy, Israel, Japan] Lehmann J.M., Hoffmann B., Pfahl M.; "Genomic organization of the retinoic acid receptor gamma gene."; Nucleic Acids Res. 19:573-578(1991).
[4] X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 178-423. MEDLINE; 96107307. [NCBI, ExPASy, Israel, Japan] Renaud J.-P., Rochel N., Ruff M., Vivat V., Chambon P., Gronemeyer H., Moras D.; "Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid."; Nature 378:681-689(1995).
[5] X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 178-423. MEDLINE; 98162555. [NCBI, ExPASy, Israel, Japan] Klaholz B.P., Renaud J.-P., Mitschler A., Zusi C., Chambon P., Gronemeyer H., Moras D.; "Conformational adaptation of agonists to the human nuclear receptor RAR gamma."; Nat. Struct. Biol. 5:199-202(1998).
Comments
FUNCTION: THIS IS A RECEPTOR FOR RETINOIC ACID. THIS METABOLITE HAS PROFOUND EFFECTS ON VERTEBRATE DEVELOPMENT. RETINOIC ACID IS A MORPHOGEN AND IS A POWERFUL TERATOGEN. THIS RECEPTOR CONTROLS CELLS FUNCTIONS BY DIRECTLY REGULATING GENE EXPRESSION. SUBCELLULAR LOCATION: NUCLEAR. ALTERNATIVE PRODUCTS: RAR-GAMMA-1 AND -2 ARE PRODUCED BY ALTERNATIVE SPLICING OF THE SAME GENE AND ONLY DIFFER IN THEIR N-TERMINAL SECTION. DOMAIN: COMPOSED OF THREE DOMAINS: A MODULATING N-TERMINAL DOMAIN, A DNA-BINDING DOMAIN AND A C-TERMINAL STEROID-BINDING DOMAIN. SIMILARITY: BELONGS TO THE NUCLEAR HORMONE RECEPTORS FAMILY. NR1 SUBFAMILY.
Copyright
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Cross-references
EMBL M24857; AAA52692.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M38258; AAA60254.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M57707; AAA63254.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] PIR A33903; A33903. A35573; A35573. S26848; S26848. PDB 3LBD; 02-MAR-99. [ExPASy / RCSB] 4LBD; 02-MAR-99. [ExPASy / RCSB] SWISS-3DIMAGE RRG1_HUMAN. TRANSFAC T00720; -. T01330; -. MIM 180190; -. GeneCards RARG. PRINTS PR00047; STROIDFINGER. PROSITE PS00031; NUCLEAR_RECEPTOR; 1. PFAM PF00104; hormone_rec; 1. PF00105; zf-C4; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS P13631. DOMO P13631. PROTOMAP P13631. PRESAGE P13631. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Receptor; Transcription regulation; DNA-binding; Nuclear protein; Zinc-finger; Multigene family; Alternative splicing; 3D-structure.
Features
DOMAIN 1 89 MODULATING. DNA_BIND 90 155 C4-TYPE ZINC FINGERS (TWO). ZN_FING 90 110 C4-TYPE. ZN_FING 126 150 C4-TYPE. DOMAIN 156 201 HINGE. DOMAIN 202 421 LIGAND-BINDING. FT table viewer
Sequence information
Length: 454 AA Molecular weight: 50341 Da CRC64: 1EE27B22772D4AFD [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MATNKERLFA AGALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG QPDLPKEMAS 70 80 90 100 110 120 | | | | | | LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY HYGVSSCEGC KGFFRRSIQK 130 140 150 160 170 180 | | | | | | NMVYTCHRDK NCIINKVTRN RCQYCRLQKC FEVGMSKEAV RNDRNKKKKE VKEEGSPDSY 190 200 210 220 230 240 | | | | | | ELSPQLEELI TKVSKAHQET FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK 250 260 270 280 290 300 | | | | | | IVEFAKRLPG FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH 310 320 330 340 350 360 | | | | | | NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV DKLQEPLLEA 370 380 390 400 410 420 | | | | | | LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL KMEIPGPMPP LIREMLENPE 430 440 450 | | | MFEDDSSQPG PHPNASSEDE VPGGQGKGGL KSPA P13631 in FASTA format