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NiceProt View of SWISS-PROT: P43021

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	NODA_MOUSE
Primary accession number	P43021
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 32, November 1995
Sequence was last modified in	Release 32, November 1995
Annotations were last modified in	Release 32, November 1995
Name and orig in of the protein
Protein name	NODAL [Precursor]
Synonym(s)	None
Gene name(s)	NODAL
From	Mus musculus (Mouse)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.
References
[1] SEQUENCE FROM N.A. MEDLINE; 93156841. [NCBI, ExPASy, Israel, Japan] Zhou X., Sasaki H., Lowe L., Hogan B.L., Kuehn M.R.; "Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation."; Nature 361:543-547(1993).
Comments
FUNCTION: SEEMS ESSENTIAL FOR MESODERM FORMATION AND SUBSEQUENT ORGANIZATION OF AXIAL STRUCTURES IN EARLY MOUSE DEVELOPMENT. SUBUNIT: HOMODIMER, DISULFIDE-LINKED (BY SIMILARITY). DEVELOPMENTAL STAGE: EXPRESSED IN THE NODE DURING GASTRULATION. EXPRESSION IS FIRST DETECTED IN PRIMITIVE STREAK-STAGE EMBRYOS AT ABOUT THE TIME OF MESODERM FORMATION. IT THEN BECOMES HIGHLY LOCALIZED IN THE NODE AT THE ANTERIOR OF THE PRIMITIVE STREAK. SIMILARITY: BELONGS TO THE TGF-BETA FAMILY.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL X70514; CAA49914.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] HSSP P18075; 1BMP. [HSSP ENTRY / SWISS-3DIMAGE / PDB] MGD MGI:97359; NODAL. PRINTS PR00438; GFCYSKNOT. PROSITE PS00250; TGF_BETA; 1. PFAM PF00019; TGF-beta; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS P43021. DOMO P43021. PROTOMAP P43021. PRESAGE P43021. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Developmental protein; Growth factor; Cytokine; Glycoprotein; Signal.
Features
SIGNAL 1 ? POTENTIAL. PROPEP ? 244 POTENTIAL. CHAIN 245 354 NODAL. DISULFID 254 320 BY SIMILARITY. DISULFID 283 351 BY SIMILARITY. DISULFID 287 353 BY SIMILARITY. DISULFID 319 319 INTERCHAIN (BY SIMILARITY). CARBOHYD 73 73 POTENTIAL. FT table viewer
Sequence information
Length: 354 AA [This is the length of the unprocessed precursor] Molecular weight: 40448 Da [This is the Mw of the unprocessed precursor] CRC64: 4CC4021780815356 [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MSAHSLRILL LQACWALLHP RAPTAAALPL WTRGQPSSPS PLAYMLSLYR DPLPRADIIR 70 80 90 100 110 120 | | | | | | SLQAQDVDVT GQNWTFTFDF SFLSQEEDLV WADVRLQLPG PMDIPTEGPL TIDIFHQAKG 130 140 150 160 170 180 | | | | | | DPERDPADCL ERIWMETFTV IPSQVTFASG STVLEVTKPL SKWLKDPRAL EKQVSSRAEK 190 200 210 220 230 240 | | | | | | CWHQPYTPPV PVASTNVLML YSNRPQEQRQ LGGATLLWEA ESSWRAQEGQ LSVERGGWGR 250 260 270 280 290 300 | | | | | | RQRRHHLPDR SQLCRRVKFQ VDFNLIGWGS WIIYPKQYNA YRCEGECPNP VGEEFHPTNH 310 320 330 340 350 | | | | | AYIQSLLKRY QPHRVPSTCC APVKTKPLSM LYVDNGRVLL EHHKDMIVEE CGCL P43021 in FASTA format