NiceProt View of SWISS-PROT: P15172

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	MYOD_HUMAN
Primary accession number	P15172
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 14, April 1990
Sequence was last modified in	Release 20, November 1991
Annotations were last modified in	Release 37, December 1998
Name and orig in of the protein
Protein name	MYOBLAST DETERMINATION PROTEIN 1
Synonym(s)	MYOGENIC FACTOR MYF-3
Gene name(s)	MYOD1 OR MYF3
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. MEDLINE; 91212198. [NCBI, ExPASy, Israel, Japan] Pearson-White S.H.; "Human MyoD: cDNA and deduced amino acid sequence."; Nucleic Acids Res. 19:1148-1148(1991).
[2] SEQUENCE OF 53-319 FROM N.A. TISSUE=SKELETAL MUSCLE; MEDLINE; 90059960. [NCBI, ExPASy, Israel, Japan] Braun T., Bober E., Buschhausen-Denker G., Kotz S., Grzeschik K.-H., Arnold H.H.; "Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products."; EMBO J. 8:3617-3625(1989).
Comments
FUNCTION: INVOLVED IN MUSCLE DIFFERENTIATION (MYOGENIC FACTOR). INDUCES FIBROBLASTS TO DIFFERENTIATE INTO MYOBLASTS. ACTIVATES MUSCLE-SPECIFIC PROMOTERS. INTERACTS WITH AND IS INHIBITED BY THE TWIST PROTEIN. THIS INTERACTION PROBABLY INVOLVES THE BASIC DOMAINS OF BOTH PROTEINS (BY SIMILARITY). SUBUNIT: EFFICIENT DNA BINDING REQUIRES DIMERIZATION WITH ANOTHER BHLH PROTEIN. SEEMS TO FORM ACTIVE HETERODIMERS WITH ITF-2. SUBCELLULAR LOCATION: NUCLEAR. SIMILARITY: BELONGS TO THE BASIC HELIX-LOOP-HELIX (BHLH) FAMILY OF TRANSCRIPTION FACTORS. "MYOGENIC FACTORS" SUBFAMILY.
Copyright
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Cross-references
EMBL X56677; CAA40000.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] X17650; CAA35640.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] PIR S06947; S06947. S26827; S26827. HSSP P10085; 1MDY. [HSSP ENTRY / SWISS-3DIMAGE / PDB] TRANSFAC T00519; -. T00525; -. MIM 159970; -. GeneCards MYOD1. PROSITE PS00038; HELIX_LOOP_HELIX; 1. PFAM PF00010; HLH; 1. PF01586; Basic; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS P15172. DOMO P15172. PROTOMAP P15172. PRESAGE P15172. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Myogenesis; Differentiation; Developmental protein; Nuclear protein; Transcription regulation; DNA-binding.
Features
DNA_BIND 109 121 BASIC DOMAIN. DOMAIN 122 161 HELIX-LOOP-HELIX MOTIF (BY SIMILARITY). CONFLICT 124 124 K -> E (IN REF. 2). FT table viewer
Sequence information
Length: 319 AA Molecular weight: 34490 Da CRC64: AAE935C154318770 [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MELLSPPLRD VDLTAPDGSL CSFATTDDFY DDPCFDSPDL RFFEDLDPRL MHVGALLKPE 70 80 90 100 110 120 | | | | | | EHSHFPAAVH PAPGAREDEH VRAPSGHHQA GRCLLWACKA CKRKTTNADR RKAATMRERR 130 140 150 160 170 180 | | | | | | RLSKVNEAFE TLKRCTSSNP NQRLPKVEIL RNAIRYIEGL QALLRDQDAA PPGAAAFYAP 190 200 210 220 230 240 | | | | | | GPLPPGRGGE HYSGDSDASS PRSNCSDGMM DYSGPPSGAR RRNCYEGAYY NEAPSEPRPG 250 260 270 280 290 300 | | | | | | KSAAVSSLDY LSSIVERIST ESPAAPALLL ADVPSESPPR RQEAAAPSEG ESSGDPTQSP 310 319 | | DAAPQCPAGA NPNPIYQVL P15172 in FASTA format