NiceProt View of SWISS-PROT: P11362

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	FGR1_HUMAN
Primary accession number	P11362
Secondary accession number(s)	P17049
Entered in SWISS-PROT in	Release 11, July 1989
Sequence was last modified in	Release 18, May 1991
Annotations were last modified in	Release 38, July 1999
Name and orig in of the protein
Protein name	BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1 [Precursor]
Synonym(s)	BFGF-R EC 2.7.1.112 FMS-LIKE TYROSINE KINASE-2 C-FGR
Gene name(s)	FGFR1 OR FLG OR FGFBR OR FLT2
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. TISSUE=PLACENTA; MEDLINE; 90245600. [NCBI, ExPASy, Israel, Japan] Isacchi A., Bergonzoni L., Sarmientos P.; "Complete sequence of a human receptor for acidic and basic fibroblast growth factors."; Nucleic Acids Res. 18:1906-1906(1990).
[2] SEQUENCE FROM N.A. TISSUE=NEONATAL BRAIN STEM; MEDLINE; 90360977. [NCBI, ExPASy, Israel, Japan] Dionne C.A., Crumley G.R., Bellot F., Kaplow J.M., Searfoss G., Ruta M., Burgess W.H., Jaye M., Schlessinger J.; "Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors."; EMBO J. 9:2685-2692(1990).
[3] SEQUENCE FROM N.A. MEDLINE; 92282615. [NCBI, ExPASy, Israel, Japan] Hattori Y., Odagiri H., Katoh O., Sakamoto H., Morita T., Shimotohno K., Tobinai K., Sugimura T., Terada M.; "K-sam-related gene, N-sam, encodes fibroblast growth factor receptor and is expressed in T-lymphocytic tumors."; Cancer Res. 52:3367-3371(1992).
[4] SEQUENCE FROM N.A. TISSUE=LIVER; MEDLINE; 91126480. [NCBI, ExPASy, Israel, Japan] Hou J., Kan M., McKeehan K., McBride G., Adams P., McKeehan W.L.; "Fibroblast growth factor receptors from liver vary in three structural domains."; Science 251:665-668(1991).
[5] SEQUENCE FROM N.A. MEDLINE; 92118399. [NCBI, ExPASy, Israel, Japan] Kiefer M.C., Baird A., George-Nascimento C., Nguyen T., Mason O.B., Boley L.J., Valenzuela P., Barr P.J.; "Molecular cloning of a human basic fibroblast growth factor receptor cDNA and expression of a biologically active extracellular domain in a baculovirus system."; Growth Factors 5:115-127(1991).
[6] SEQUENCE FROM N.A. TISSUE=PLACENTA; MEDLINE; 90290512. [NCBI, ExPASy, Israel, Japan] Itoh N., Terachi T., Ohta M., Seo M.K.; "The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA."; Biochem. Biophys. Res. Commun. 169:680-685(1990).
[7] SEQUENCE OF 201-822 FROM N.A. Ruta M., Howk R., Ricca G., Drohan W., Zabelshansky M., Laureys G., Barton D.E., Francke U., Schlessinger J., Givol D.; "A novel protein tyrosine kinase gene whose expression is modulated during endothelial cell differentiation."; Oncogene 3:9-15(1988).
[8] SEQUENCE FROM N.A., AND ALTERNATIVE SPLICING. MEDLINE; 90355989. [NCBI, ExPASy, Israel, Japan] Johnson D.E., Lee P.L., Lu J., Williams L.T.; "Diverse forms of a receptor for acidic and basic fibroblast growth factors."; Mol. Cell. Biol. 10:4728-4736(1990).
[9] ALTERNATIVE SPLICING. MEDLINE; 91141499. [NCBI, ExPASy, Israel, Japan] Gutkind S.J., Link D.C., Katamine S., Lacal P., Miki T., Ley T.J., Robbins K.C.; "A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes."; Mol. Cell. Biol. 11:1500-1507(1991).
[10] SEQUENCE FROM N.A., AND ALTERNATIVE SPLICING. TISSUE=LUNG; MEDLINE; 91319400. [NCBI, ExPASy, Israel, Japan] Eisemann A., Ahn J.A., Graziani G., Tronick S.R., Ron D.; "Alternative splicing generates at least five different isoforms of the human basic-FGF receptor."; Oncogene 6:1195-1202(1991).
[11] SEQUENCE FROM N.A. Wennstroem S., Sandstroem C., Claesson-Welsh L.; Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases.
[12] MUTAGENESIS OF TYR-766. MEDLINE; 92357144. [NCBI, ExPASy, Israel, Japan] Peters K.G., Marie J., Wilson E., Ives H.E., Escobedo J., del Rosario M., Mirda D., Williams L.T.; "Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis."; Nature 358:678-681(1992).
[13] MUTAGENESIS OF TYR-766. MEDLINE; 92357145. [NCBI, ExPASy, Israel, Japan] Mohammadi M., Dionne C.A., Li W., Lin N., Spivak T., Honegger A.M., Jaye M., Schlessinger J.; "Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis."; Nature 358:681-684(1992).
[14] X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 464-762. MEDLINE; 96361355. [NCBI, ExPASy, Israel, Japan] Mohammadi M., Schlessinger J., Hubbard S.R.; "Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism."; Cell 86:577-587(1996).
[15] X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 464-762. MEDLINE; 97284786. [NCBI, ExPASy, Israel, Japan] Mohammadi M., McMahon G., Sun L., Tang C., Hirth P., Yeh B.K., Hubbard S.R., Schlessinger J.; "Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors."; Science 276:955-960(1997).
[16] VARIANT PFEIFFER SYNDROME ARG-252. MEDLINE; 95179173. [NCBI, ExPASy, Israel, Japan] Muenke M., Schell U., Hehr A., Robin N.H., Losken H.W., Schinzel A., Pulleyn L.J., Rutland P., Reardon W., Malcolm S., Winter R.M.; "A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome."; Nat. Genet. 8:269-274(1994).
Comments
FUNCTION: RECEPTOR FOR BASIC FIBROBLAST GROWTH FACTOR. A SHORTER FORM OF THE RECEPTOR COULD BE A RECEPTOR FOR ACIDIC FGF (AFGF). CATALYTIC ACTIVITY: ATP + PROTEIN TYROSINE = ADP + PROTEIN TYROSINE PHOSPHATE. SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN. ALTERNATIVE PRODUCTS: MANY FORMS OF FGFR1 ARE PRODUCED BY ALTERNATIVE SPLICING. THE FORM SHOWN HERE IS KNOWN AS ALPHA-A1. DISEASE: DEFECTS IN FGFR1 ARE ONE OF THE CAUSES OF PFEIFFER SYNDROME, ALSO CALLED ACROCEPHALOSYNDACTYLY TYPE V (ACS V), CHARACTERIZED BY CRANIOSYNOSTOSIS (PREMATURE FUSION OF THE SKULL SUTURES) WITH DEVIATION AND ENLARGEMENT OF THE THUMBS AND GREAT TOES, BRACHYMESOPHALANGY, WITH PHALANGEAL ANKYLOSIS AND A VARYING DEGREE OF SOFT TISSUE SYNDACTYLY. SIMILARITY: BELONGS TO THE FIBROBLAST GROWTH FACTOR RECEPTOR FAMILY. SIMILARITY: CONTAINS 3 IMMUNOGLOBULIN-LIKE DOMAINS.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL X51803; CAA36101.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] X52833; CAA37015.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] X66945; CAA47375.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] Y00665; CAA68679.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M37722; AAA75007.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M60485; AAA35840.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M63887; AAA35958.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M34185; AAA35836.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M34186; AAA35837.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] X57118; CAA40400.1; ALT_TERM. [EMBL / GenBank / DDBJ] [CoDingSequence] X57119; CAA40401.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] X57120; CAA40402.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] X57121; CAA40403.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] X57122; CAA40404.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M34641; AAA35835.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] A29216; CAA01958.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] PIR S11692; TVHUFG. S25420; S25420. S26739; S26739. PDB 1FGK; 23-JUL-97. [ExPASy / RCSB] 1FGI; 08-APR-98. [ExPASy / RCSB] 1AGW; 25-MAR-98. [ExPASy / RCSB] SWISS-3DIMAGE FGR1_HUMAN. MIM 136350; -. 101600; -. GeneCards FGFR1. PRINTS PR00109; TYRKINASE. PROSITE PS00107; PROTEIN_KINASE_ATP; 1. PS00109; PROTEIN_KINASE_TYR; 1. PS50011; PROTEIN_KINASE_DOM; 1. PFAM PF00047; ig; 3. PF00069; pkinase; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS P11362. DOMO P11362. PROTOMAP P11362. PRESAGE P11362. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Receptor; Glycoprotein; Tyrosine-protein kinase; ATP-binding; Transferase; Phosphorylation; Transmembrane; Signal; 3D-structure; Immunoglobulin domain; Alternative splicing; Disease mutation.
Features
SIGNAL 1 21 POTENTIAL. CHAIN 22 822 BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1. DOMAIN 22 376 EXTRACELLULAR (POTENTIAL). TRANSMEM 377 397 POTENTIAL. DOMAIN 398 822 CYTOPLASMIC (POTENTIAL). DOMAIN 48 108 IG-LIKE DOMAIN. DOMAIN 171 237 IG-LIKE DOMAIN. DOMAIN 270 348 IG-LIKE DOMAIN. DOMAIN 478 767 PROTEIN KINASE. NP_BIND 484 492 ATP (BY SIMILARITY). BINDING 514 514 ATP (BY SIMILARITY). ACT_SITE 623 623 BY SIMILARITY. MOD_RES 654 654 PHOSPHORYLATION (AUTO-) (BY SIMILARITY). MOD_RES 766 766 PHOSPHORYLATION (AUTO-). MUTAGEN 766 766 Y->F: FAILS TO INTERACT WITH PLC-GAMMA. DISULFID 55 101 POTENTIAL. DISULFID 178 230 POTENTIAL. DISULFID 277 341 POTENTIAL. CARBOHYD 77 77 POTENTIAL. CARBOHYD 117 117 POTENTIAL. CARBOHYD 227 227 POTENTIAL. CARBOHYD 240 240 POTENTIAL. CARBOHYD 264 264 POTENTIAL. CARBOHYD 296 296 POTENTIAL. CARBOHYD 317 317 POTENTIAL. CARBOHYD 330 330 POTENTIAL. VARSPLIC 1 160 MISSING (IN ISOFORM GAMMA A1). VARSPLIC 31 119 MISSING (IN ISOFORM BETA A1 AND ISOFORM BETA B1). VARSPLIC 428 429 MISSING (IN ISOFORM ALPHA B1, ISOFORM BETA B1 AND ISOFORM GAMMA B1). VARSPLIC 148 149 MISSING (IN A FORM). VARIANT 252 252 P -> R (IN PFEIFFER SYNDROME). /FTId=VAR_004111. CONFLICT 24 24 S -> C (IN REF. 4). CONFLICT 192 192 K -> E (IN REF. 8). CONFLICT 194 194 G -> S (IN REF. 11). CONFLICT 308 308 V -> A (IN REF. 4). CONFLICT 364 364 E -> Q (IN REF. 7). CONFLICT 469 469 P -> L (IN REF. 6). CONFLICT 817 817 G -> R (IN REF. 1). FT table viewer
Sequence information
Length: 822 AA [This is the length of the unprocessed precursor] Molecular weight: 91867 Da [This is the Mw of the unprocessed precursor] CRC64: 93A01B5D78C3E72C [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD 70 80 90 100 110 120 | | | | | | VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD 130 140 150 160 170 180 | | | | | | ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS 190 200 210 220 230 240 | | | | | | SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN 250 260 270 280 290 300 | | | | | | HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI 310 320 330 340 350 360 | | | | | | GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE 370 380 390 400 410 420 | | | | | | ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK SGTKKSDFHS QMAVHKLAKS 430 440 450 460 470 480 | | | | | | IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL 490 500 510 520 530 540 | | | | | | GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK 550 560 570 580 590 600 | | | | | | HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL 610 620 630 640 650 660 | | | | | | VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG 670 680 690 700 710 720 | | | | | | RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD 730 740 750 760 770 780 | | | | | | KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF 790 800 810 820 | | | | PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR P11362 in FASTA format