NiceProt View of SWISS-PROT: P55075

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	FGF8_HUMAN
Primary accession number	P55075
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 34, October 1996
Sequence was last modified in	Release 34, October 1996
Annotations were last modified in	Release 39, February 2000
Name and orig in of the protein
Protein name	ANDROGEN-INDUCED GROWTH FACTOR [Precursor]
Synonym(s)	AIGF HBGF-8 FIBROBLAST GROWTH FACTOR-8 FGF-8
Gene name(s)	FGF8 OR AIGF
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. TISSUE=PROSTATE; Ghosh A.K., Shankar D.B., Shackleford G.M., Miller G., Zheng J., Macarthur C.A., Roy-Burman P.; Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
[2] SEQUENCE FROM N.A. (FGF-8A). MEDLINE; 95255551. [NCBI, ExPASy, Israel, Japan] Tanaka A., Miyamoto K., Matsuo H., Matsumoto K., Yoshida H.; "Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties."; FEBS Lett. 363:226-230(1995).
[3] SEQUENCE FROM N.A. (FGF-8A). Payson R.A., Wu J., Liu Y., Chiu I.M.; Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
[4] SEQUENCE FROM N.A. (FGF-8E). TISSUE=PLACENTA; Gemel J., Gorry M., Ehrlich G.D., Macarthur C.A.; Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
Comments
FUNCTION: STIMULATES GROWTH OF THE CELLS IN AN AUTOCRINE MANNER. MEDIATES HORMONAL ACTION ON THE GROWTH OF CANCER CELLS. ALTERNATIVE PRODUCTS: AT LEAST THREE FORMS; FGF-8A, FGF-8B AND FGF-8E (SHOWN HERE); ARE PRODUCED BY ALTERNATIVE SPLICING. SIMILARITY: BELONGS TO THE HEPARIN-BINDING GROWTH FACTORS FAMILY.
Copyright
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Cross-references
EMBL U46213; AAB40955.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] U46212; AAB40954.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] U46211; AAB40953.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] S78466; AAB34255.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] S78462; AAB34255.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] S78463; AAB34255.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] S78464; AAB34255.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] S78465; AAB34255.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] U36223; AAB17893.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] U36228; AAB17894.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] U36225; AAB17894.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] U36226; AAB17894.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] U36227; AAB17894.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] U47011; AAC50784.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] U47009; AAC50784.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] U47010; AAC50784.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] HSSP P09038; 1FGA. [HSSP ENTRY / SWISS-3DIMAGE / PDB] MIM 600483; -. GeneCards FGF8. PROSITE PS00247; HBGF_FGF; 1. PFAM PF00167; FGF; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS P55075. DOMO P55075. PROTOMAP P55075. PRESAGE P55075. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Growth factor; Mitogen; Alternative splicing; Signal.
Features
SIGNAL 1 22 POTENTIAL. CHAIN 23 233 ANDROGEN-INDUCED GROWTH FACTOR. CARBOHYD 155 155 POTENTIAL. VARSPLIC 24 51 EGPGRGPALGRELASLFRAGREPQGVSQ -> VTVQSSPNF T (IN ISOFORM FGF-8B). VARSPLIC 24 52 MISSING (IN ISOFORM FGF-8A). FT table viewer
Sequence information
Length: 233 AA [This is the length of the unprocessed precursor] Molecular weight: 26525 Da [This is the Mw of the unprocessed precursor] CRC64: 4C1EAF932A3A211D [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS QQHVREQSLV 70 80 90 100 110 120 | | | | | | TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP FAKLIVETDT FGSRVRVRGA 130 140 150 160 170 180 | | | | | | ETGLYICMNK KGKLIAKSNG KGKDCVFTEI VLENNYTALQ NAKYEGWYMA FTRKGRPRKG 190 200 210 220 230 | | | | | SKTRQHQREV HFMKRLPRGH HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR P55075 in FASTA format