Entry name
FGF4_HUMAN
Primary accession number
P08620
Secondary accession number(s)
None
Entered in SWISS-PROT in
Release 08, August 1988
Sequence was last modified in
Release 08, August 1988
Annotations were last modified in
Release 33, February 1996
Protein name
FIBROBLAST GROWTH FACTOR-4 [Precursor]
Synonym(s)
FGF-4
HEPARIN SECRETORY TRANSFORMING PROTEIN
HST-1
HST
TRANSFORMING PROTEIN KS3
HBGF- 4
Gene name(s)
FGF4 OR HST OR HSTF1 OR KS3
From
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
[1]
SEQUENCE FROM N.A.
MEDLINE; 88041096. [NCBI,
ExPASy,
Israel,
Japan]
Yoshida T.,
Miyagawa K.,
Odagiri H.,
Sakamoto H.,
Little P.F.R.,
Terada M.,
Sugimura T.;
"Genomic sequence of hst, a transforming gene encoding a
protein homologous to fibroblast growth factors and the
int-2-encoded protein.";
Proc. Natl. Acad. Sci. U.S.A. 84:7305-7309(1987).
[2]
SEQUENCE FROM N.A.
MEDLINE; 87204251. [NCBI,
ExPASy,
Israel,
Japan]
Taira M.,
Yoshida T.,
Miyagawa K.,
Sakamoto H.,
Terada M.,
Sugimura T.;
"cDNA sequence of human transforming gene hst and
identification of the coding sequence required for
transforming activity.";
Proc. Natl. Acad. Sci. U.S.A. 84:2980-2984(1987).
[3]
SEQUENCE FROM N.A.
MEDLINE; 87301716. [NCBI,
ExPASy,
Israel,
Japan]
Delli Bovi P.,
Curatola A.M.,
Kern F.G.,
Greco A.,
Ittmann M.,
Basilico C.;
"An oncogene isolated by transfection of Kaposi's sarcoma
DNA encodes a growth factor that is a member of the FGF
family.";
Cell
50:729-737(1987).
- FUNCTION: CAN TRANSFORM NIH 3T3 CELLS FROM A HUMAN STOMACH TUMOR (HST) AND FROM KARPOSI'S SARCOMA (KS3). IT HAS A MITOGENIC ACTIVITY.
- SIMILARITY: BELONGS TO THE HEPARIN-BINDING GROWTH FACTORS FAMILY.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
|
EMBL |
J02986; AAB59555.1; -. [EMBL
/ GenBank
/ DDBJ]
[CoDingSequence] |
|
PIR |
A28417; TVHUHS. |
|
HSSP |
P09038;
1BFF. [HSSP
ENTRY / SWISS-3DIMAGE
/ PDB] |
|
MIM |
|
|
GeneCards |
|
|
PRINTS |
|
|
PROSITE |
|
|
PFAM |
|
|
PRODOM |
|
|
BLOCKS |
|
|
DOMO |
|
|
PROTOMAP |
|
|
PRESAGE |
|
|
SWISS-2DPAGE |
Transforming protein; Oncogene; Growth factor; Mitogen; Signal.
|
SIGNAL 1 ? POTENTIAL.
CHAIN ? 206 FIBROBLAST GROWTH FACTOR-4.
|
FT
table viewer |
|
Length: 206 AA [This is the length of the unprocessed precursor] |
Molecular weight: 22047 Da [This is the Mw of the unprocessed precursor] |
CRC64: C7FD54A0272A1569 [This is a checksum on the sequence] |
10 20 30 40 50 60
| | | | | |
MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL VALSLARLPV
70 80 90 100 110 120
| | | | | |
AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP
130 140 150 160 170 180
| | | | | |
VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA
190 200 206
| | |
LSKNGKTKKG NRVSPTMKVT HFLPRL
|
P08620 in FASTA format |
