NiceProt View of SWISS-PROT: O15520

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	FGFA_HUMAN
Primary accession number	O15520
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 38, July 1999
Sequence was last modified in	Release 38, July 1999
Annotations were last modified in	Release 38, July 1999
Name and orig in of the protein
Protein name	FIBROBLAST GROWTH FACTOR-10 [Precursor]
Synonym(s)	FGF-10 KERATINOCYTE GROWTH FACTOR 2
Gene name(s)	FGF10
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. TISSUE=LUNG; MEDLINE; 97435285. [NCBI, ExPASy, Israel, Japan] Emoto H., Tagashira S., Mattei M.G., Yamasaki M., Hashimoto G., Katsumata T., Negoro T., Nakatsuka M., Birnbaum D., Coulier F., Itoh N.; "Structure and expression of human fibroblast growth factor-10."; J. Biol. Chem. 272:23191-23194(1997).
[2] SEQUENCE FROM N.A. TISSUE=LUNG; Jimenez P.A., Gruber J.R., Liu B., Feng P., Florence C., Blunt A., Huddleston K.A., Teliska M., Alfonso P., Coleman T.A., Ornitz D.M., Dillon P.A., Duan R.D.; "Cutaneous wound healing by keratinocyte growth factor 2."; Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
Comments
FUNCTION: COULD BE A GROWTH FACTOR ACTIVE IN THE PROCESS OF WOUND HEALING. ACTS AS A MITOGEN IN THE LUNG. MAY ACT IN A MANNER SIMILAR TO FGF-7. SUBCELLULAR LOCATION: SECRETED (POTENTIAL). SIMILARITY: BELONGS TO THE HEPARIN-BINDING GROWTH FACTORS FAMILY.
Copyright
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Cross-references
EMBL AB002097; BAA22331.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] U67918; AAB61991.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] MIM 602115; -. GeneCards FGF10. PRINTS PR00263; HBGFFGF. PROSITE PS00247; HBGF_FGF; 1. PFAM PF00167; FGF; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS O15520. DOMO O15520. PROTOMAP O15520. PRESAGE O15520. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Growth factor; Glycoprotein; Signal.
Features
SIGNAL 1 37 POTENTIAL. CHAIN 38 208 FIBROBLAST GROWTH FACTOR-10. DOMAIN 19 23 POLY-CYS. DOMAIN 52 62 POLY-SER. CARBOHYD 51 51 POTENTIAL. CARBOHYD 196 196 POTENTIAL. FT table viewer
Sequence information
Length: 208 AA [This is the length of the unprocessed precursor] Molecular weight: 23436 Da [This is the Mw of the unprocessed precursor] CRC64: C0A0705C108680B3 [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MWKWILTHCA SAFPHLPGCC CCCFLLLFLV SSVPVTCQAL GQDMVSPEAT NSSSSSFSSP 70 80 90 100 110 120 | | | | | | SSAGRHVRSY NHLQGDVRWR KLFSFTKYFL KIEKNGKVSG TKKENCPYSI LEITSVEIGV 130 140 150 160 170 180 | | | | | | VAVKAINSNY YLAMNKKGKL YGSKEFNNDC KLKERIEENG YNTYASFNWQ HNGRQMYVAL 190 200 208 | | | NGKGAPRRGQ KTRRKNTSAH FLPMVVHS O15520 in FASTA format