NiceProt View of SWISS-PROT: P05230

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	FGF1_HUMAN
Primary accession number	P05230
Secondary accession number(s)	P07502
Entered in SWISS-PROT in	Release 05, August 1987
Sequence was last modified in	Release 05, August 1987
Annotations were last modified in	Release 38, July 1999
Name and orig in of the protein
Protein name	HEPARIN-BINDING GROWTH FACTOR 1 [Precursor]
Synonym(s)	HBGF-1 ACIDIC FIBROBLAST GROWTH FACTOR AFGF BETA-ENDOTHELIAL CELL GROWTH FACTOR ECGF- BETA
Gene name(s)	FGF1 OR FGFA
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. MEDLINE; 86261805. [NCBI, ExPASy, Israel, Japan] Jaye M., Howk R., Burgess W., Ricca G.A., Chiu I.-M., Ravera M.W., O'Brien S.J., Modi W.S., Maciag T., Drohan W.N.; "Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization."; Science 233:541-545(1986).
[2] SEQUENCE FROM N.A. TISSUE=BRAIN STEM; MEDLINE; 89343957. [NCBI, ExPASy, Israel, Japan] Wang W.P., Lehtoma K., Varban M.L., Krishnan I., Chiu I.M.; "Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues."; Mol. Cell. Biol. 9:2387-2395(1989).
[3] SEQUENCE FROM N.A. TISSUE=BRAIN STEM; MEDLINE; 90265618. [NCBI, ExPASy, Israel, Japan] Chiu I.M., Wang W.P., Lehtoma K.; "Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1."; Oncogene 5:755-762(1990).
[4] SEQUENCE FROM N.A. MEDLINE; 90073637. [NCBI, ExPASy, Israel, Japan] Mergia A., Tischer E., Graves D., Tumolo A., Miller J., Gospodarowicz D., Abraham J.A., Shipley G.D., Fiddes J.C.; "Structural analysis of the gene for human acidic fibroblast growth factor."; Biochem. Biophys. Res. Commun. 164:1121-1129(1989).
[5] SEQUENCE FROM N.A. MEDLINE; 92019819. [NCBI, ExPASy, Israel, Japan] Wang W.P., Quick D., Balcerzak S.P., Needleman S.W., Chiu I.M.; "Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients."; Oncogene 6:1521-1529(1991).
[6] SEQUENCE FROM N.A. MEDLINE; 92202857. [NCBI, ExPASy, Israel, Japan] Li Y.L., Kha H., Golden J.A., Migchielsen A.A.J., Goetzl E.J., Turck E.J.; "An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist."; J. Exp. Med. 175:1073-1080(1992).
[7] SEQUENCE OF 1-154 FROM N.A. MEDLINE; 94069734. [NCBI, ExPASy, Israel, Japan] Zhao X.M., Yeoh T.K., Hiebert M., Frist W.H., Miller G.G.; "The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells."; Transplantation 56:1177-1182(1993).
[8] SEQUENCE OF 1-40 FROM N.A. MEDLINE; 90365758. [NCBI, ExPASy, Israel, Japan] Crumley G., Dionne C.A., Jaye M.; "The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon."; Biochem. Biophys. Res. Commun. 171:7-13(1990).
[9] SEQUENCE OF 16-155. MEDLINE; 86296647. [NCBI, ExPASy, Israel, Japan] Harper J.W., Strydom D.J., Lobb R.R.; "Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor."; Biochemistry 25:4097-4103(1986).
[10] SEQUENCE OF 16-155. MEDLINE; 86295741. [NCBI, ExPASy, Israel, Japan] Gimenez-Gallego G., Conn G., Hatcher V.B., Thomas K.A.; "The complete amino acid sequence of human brain-derived acidic fibroblast growth factor."; Biochem. Biophys. Res. Commun. 138:611-617(1986).
[11] SEQUENCE OF 16-155. MEDLINE; 87048871. [NCBI, ExPASy, Israel, Japan] Gautschi-Sova P., Muller T., Bohlen P.; "Amino acid sequence of human acidic fibroblast growth factor."; Biochem. Biophys. Res. Commun. 140:874-880(1986).
[12] SEQUENCE OF 16-47. MEDLINE; 86186784. [NCBI, ExPASy, Israel, Japan] Gimenez-Gallego G., Conn G., Hatcher V.B., Thomas K.A.; "Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities."; Biochem. Biophys. Res. Commun. 135:541-548(1986).
[13] SEQUENCE OF 16-49. MEDLINE; 86275260. [NCBI, ExPASy, Israel, Japan] Gautschi P., Frater-Schroder M., Bohlen P.; "Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors."; FEBS Lett. 204:203-207(1986).
[14] X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS). MEDLINE; 96194129. [NCBI, ExPASy, Israel, Japan] Blaber M., Disalvo J., Thomas K.A.; "X-ray crystal structure of human acidic fibroblast growth factor."; Biochemistry 35:2086-2094(1996).
[15] STRUCTURE BY NMR OF 24-155. MEDLINE; 94358885. [NCBI, ExPASy, Israel, Japan] Pineda-Lucena A., Jimenez M.A., Nieto J.L., Santoro J., Rico M., Gimenez-Gallego G.; "1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate."; J. Mol. Biol. 242:81-98(1994).
[16] STRUCTURE BY NMR OF 24-155. MEDLINE; 97107535. [NCBI, ExPASy, Israel, Japan] Pineda-Lucena A., Jimenez M.A., Lozano R.M., Nieto J.L., Santoro J., Rico M., Gimenez-Gallego G.; "Three-dimensional structure of acidic fibroblast growth factor in solution: effects of binding to a heparin functional analog."; J. Mol. Biol. 264:162-178(1996).
[17] STRUCTURE BY NMR OF 25-155. MEDLINE; 98387896. [NCBI, ExPASy, Israel, Japan] Lozano R.M., Jimenez M., Santoro J., Rico M., Gimenez-Gallego G.; "Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas."; J. Mol. Biol. 281:899-915(1998).
Comments
FUNCTION: THE HEPARIN-BINDING GROWTH FACTORS ARE ANGIOGENIC AGENTS IN VIVO AND ARE POTENT MITOGENS FOR A VARIETY OF CELL TYPES IN VITRO. THERE ARE DIFFERENCES IN THE TISSUE DISTRIBUTION AND CONCENTRATION OF THESE 2 GROWTH FACTORS. SUBUNIT: MONOMER. MISCELLANEOUS: THIS PROTEIN BINDS HEPARIN, ALTHOUGH LESS STRONGLY THAN DOES BFGF. SIMILARITY: BELONGS TO THE HEPARIN-BINDING GROWTH FACTORS FAMILY.
Copyright
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Cross-references
EMBL M13361; AAA79245.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] X51943; CAA36206.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M30492; AAA52446.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M30490; AAA52446.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] M30491; AAA52446.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] M60515; AAA51672.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M60516; AAA51673.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M23087; AAA52638.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M23086; AAA52638.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] S67291; AAB29057.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] X65778; CAA46661.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] PIR A23553; A23553. A24243; A24243. A24301; A24301. A24662; A24662. A24820; A24820. A26386; A26386. A33665; A33665. S18217; S18217. PDB 2AFG; 15-OCT-95. [ExPASy / RCSB] 1AXM; 22-APR-98. [ExPASy / RCSB] 2AXM; 22-APR-98. [ExPASy / RCSB] 1RML; 11-NOV-98. [ExPASy / RCSB] SWISS-3DIMAGE FGF1_HUMAN. MIM 131220; -. GeneCards FGF1. PRINTS PR00262; IL1HBGF. PR00263; HBGFFGF. PROSITE PS00247; HBGF_FGF; 1. PFAM PF00167; FGF; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS P05230. DOMO P05230. PROTOMAP P05230. PRESAGE P05230. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Growth factor; Mitogen; Vascularization; Heparin-binding; Acetylation; 3D-structure.
Features
PROPEP 1 15 CHAIN 16 155 HEPARIN-BINDING GROWTH FACTOR 1. MOD_RES 2 2 ACETYLATION. BINDING 24 28 HEPARIN (POTENTIAL). BINDING 113 116 HEPARIN (POTENTIAL). FT table viewer
Sequence information
Length: 155 AA [This is the length of the unprocessed precursor] Molecular weight: 17460 Da [This is the Mw of the unprocessed precursor] CRC64: F586E8BFB09F1580 [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ 70 80 90 100 110 120 | | | | | | LSAESVGEVY IKSTETGQYL AMDTDGLLYG SQTPNEECLF LERLEENHYN TYISKKHAEK 130 140 150 155 | | | | NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD P05230 in FASTA format