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General
information about the entry
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Entry name
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HMAN_DROME
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Primary accession number
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P02833
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Secondary accession number(s)
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None
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Entered in SWISS-PROT in
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Release 01, July 1986
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Sequence was last modified in
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Release 09, November 1988
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Annotations were last modified in
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Release 39, February 2000
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Name and origin
of the protein
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Protein name
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HOMEOTIC ANTENNAPEDIA PROTEIN
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Synonym(s)
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None
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Gene name(s)
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ANTP
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From
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Drosophila
melanogaster (Fruit fly)
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Taxonomy
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Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda;
Insecta; Pterygota; Neoptera; Endopterygota; Diptera;
Brachycera; Muscomorpha; Ephydroidea; Drosophilidae;
Drosophila.
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References
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[1]
SEQUENCE FROM N.A.
Schneuwly S.,
Kuroiwa A.,
Baumgartner P.,
Gehring W.J.;
"Structural organization and sequence of the homeotic gene
Antennapedia of Drosophila melanogaster.";
EMBO J. 5:733-739(1986).
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[2]
SEQUENCE FROM N.A.
MEDLINE; 87089828. [NCBI,
ExPASy,
Israel,
Japan]
Stroeher V.L.,
Jorgensen E.M.,
Garber R.L.;
"Multiple transcripts from the Antennapedia gene of
Drosophila melanogaster.";
Mol. Cell. Biol. 6:4667-4675(1986).
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[3]
SEQUENCE FROM N.A.
Celniker S.E.,
Pfeiffer B.,
Knafels J.,
Martin C.H.,
Mayeda C.A.,
Palazzolo M.J.;
"Complete sequence of the Antennapedia complex of
Drosophila.";
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
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[4]
SEQUENCE OF 296-378 FROM N.A.
MEDLINE; 84205674. [NCBI,
ExPASy,
Israel,
Japan]
McGinnis W.,
Garber R.L.,
Wirz J.,
Kuroiwa A.,
Gehring W.J.;
"A homologous protein-coding sequence in Drosophila homeotic
genes and its conservation in other metazoans.";
Cell
37:403-408(1984).
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[5]
SEQUENCE OF 296-364 FROM N.A.
MEDLINE; 84248068. [NCBI,
ExPASy,
Israel,
Japan]
Scott M.P.,
Weiner A.J.;
"Structural relationships among genes that control
development: sequence homology between the Antennapedia,
Ultrabithorax, and fushi tarazu loci of Drosophila.";
Proc. Natl. Acad. Sci. U.S.A. 81:4115-4119(1984).
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[6]
SEQUENCE OF 297-357 FROM N.A.
MEDLINE; 86079516. [NCBI,
ExPASy,
Israel,
Japan]
Regulski M.,
Harding K.,
Kostriken R.,
Karch F.,
Levine M.,
McGinnis W.;
"Homeo box genes of the Antennapedia and bithorax complexes
of Drosophila.";
Cell
43:71-80(1985).
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[7]
STRUCTURE BY NMR OF HOMEOBOX.
MEDLINE; 90317820. [NCBI,
ExPASy,
Israel,
Japan]
Billeter M.,
Qian Y.-Q.,
Otting G.,
Mueller M.,
Gehring W.J.,
Wuethrich K.;
"Determination of the three-dimensional structure of the
Antennapedia homeodomain from Drosophila in solution by 1H
nuclear magnetic resonance spectroscopy.";
J. Mol. Biol. 214:183-197(1990).
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[8]
STRUCTURE BY NMR OF HOMOEBOX.
MEDLINE; 94087721. [NCBI,
ExPASy,
Israel,
Japan]
Qian Y.-Q.,
Otting G.,
Billeter M.,
Mueller M.,
Gehring W.J.,
Wuethrich K.;
"Nuclear magnetic resonance spectroscopy of a DNA complex
with the uniformly 13C-labeled Antennapedia homeodomain and
structure determination of the DNA-bound homeodomain.";
J. Mol. Biol. 234:1070-1083(1993).
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[9]
STRUCTURE BY NMR OF HOMOEBOX.
MEDLINE; 94087722. [NCBI,
ExPASy,
Israel,
Japan]
Billeter M.,
Qian Y.-Q.,
Otting G.,
Mueller M.,
Gehring W.J.,
Wuethrich K.;
"Determination of the nuclear magnetic resonance solution
structure of an Antennapedia homeodomain-DNA complex.";
J. Mol. Biol. 234:1084-1097(1993).
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[10]
STRUCTURE BY NMR OF 279-363.
MEDLINE; 93066318. [NCBI,
ExPASy,
Israel,
Japan]
Qian Y.-Q.,
Otting G.,
Furukubo-Tokinaga K.,
Affolter M.,
Gehring W.J.,
Wuethrich K.;
"NMR structure determination reveals that the homeodomain is
connected through a flexible linker to the main body in the
Drosophila Antennapedia protein.";
Proc. Natl. Acad. Sci. U.S.A. 89:10738-10742(1992).
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[11]
X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 297-356.
MEDLINE; 98363212. [NCBI,
ExPASy,
Israel,
Japan]
Fraenkel E.,
Pabo C.O.;
"Comparison of X-ray and NMR structures for the Antennapedia
homeodomain-DNA complex.";
Nat. Struct. Biol. 5:692-697(1998).
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Comments
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- FUNCTION: SEQUENCE-SPECIFIC
TRANSCRIPTION FACTOR WHICH IS PART OF A DEVELOPMENTAL
REGULATORY SYSTEM THAT PROVIDES CELLS WITH SPECIFIC
POSITIONAL IDENTITIES ON THE ANTERIOR-POSTERIOR
AXIS.
- FUNCTION: THIS HOMEOTIC PROTEIN
CONTROLS DEVELOPMENT OF THE CELLS IN THE MESOTHORAX
SEGMENTS.
- SUBCELLULAR LOCATION: NUCLEAR
(PROBABLE).
- SIMILARITY: BELONGS TO THE ANTP FAMILY
OF HOMEOBOX PROTEINS.
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Copyright
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This SWISS-PROT entry is copyright. It is
produced through a collaboration between the Swiss Institute
of Bioinformatics and the EMBL outstation - the European
Bioinformatics Institute. There are no restrictions on its
use by non-profit institutions as long as its content is in
no way modified and this statement is not removed. Usage by
and for commercial entities requires a license agreement
(See http://www.isb-sib.ch/announce/
or send an email to license@isb-sib.ch).
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Cross-references
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Keywords
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Homeobox; DNA-binding; Developmental protein; Nuclear
protein; 3D-structure.
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Features
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Sequence
information
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Length: 378 AA
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Molecular weight: 42761 Da
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CRC64: D653232A8622D055 [This is a
checksum on the sequence]
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10 20 30 40 50 60
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MTMSTNNCES MTSYFTNSYM GADMHHGHYP GNGVTDLDAQ QMHHYSQNAN HQGNMPYPRF
70 80 90 100 110 120
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PPYDRMPYYN GQGMDQQQQH QVYSRPDSPS SQVGGVMPQA QTNGQLGVPQ QQQQQQQQPS
130 140 150 160 170 180
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QNQQQQQAQQ APQQLQQQLP QVTQQVTHPQ QQQQQPVVYA SCKLQAAVGG LGMVPEGGSP
190 200 210 220 230 240
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PLVDQMSGHH MNAQMTLPHH MGHPQAQLGY TDVGVPDVTE VHQNHHNMGM YQQQSGVPPV
250 260 270 280 290 300
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GAPPQGMMHQ GQGPPQMHQG HPGQHTPPSQ NPNSQSSGMP SPLYPWMRSQ FGKCQERKRG
310 320 330 340 350 360
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RQTYTRYQTL ELEKEFHFNR YLTRRRRIEI AHALCLTERQ IKIWFQNRRM KWKKENKTKG
370 378
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EPGSGGEGDE ITPPNSPQ
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P02833 in FASTA
format
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