NiceProt View of SWISS-PROT: Q06633

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	ZP3B_HUMAN
Primary accession number	Q06633
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 30, October 1994
Sequence was last modified in	Release 30, October 1994
Annotations were last modified in	Release 39, February 2000
Name and orig in of the protein
Protein name	ZONA PELLUCIDA SPERM-BINDING PROTEIN 3B [Precursor]
Synonym(s)	ZONA PELLUCIDA GLYCOPROTEIN ZP3B SPERM RECEPTOR ZP3
Gene name(s)	ZP3B
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. TISSUE=OVARY; MEDLINE; 93122771. [NCBI, ExPASy, Israel, Japan] van Duin M., Polman J.E., Verkoelen C.C., Bunschoten H., Meyerink J.H., Olijve W., Aitken R.J.; "Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations."; Genomics 14:1064-1070(1992).
Comments
FUNCTION: FUNCTIONS AS A SPERM-RECEPTOR. IT IS RESPONSIBLE FOR SPERM-ADHESION TO THE ZONA PELLUCIDA, AND MAY CONTRIBUTE TO THE SPECIES-SPECIFICITY OF THE INSEMINATION. SUBUNIT: ZP3 FORMS WITH ZP1 AND ZP2 THE ZONA PELLUCIDA, IN WHICH ZP2 AND ZP3 COMPLEX INTO COPOLYMERS CROSS-LINKED BY ZP1. SUBCELLULAR LOCATION: EXTRACELLULAR MATRIX. PTM: SULFATED GLYCOPROTEIN WITH O-LINKED OLIGOSACCHARIDES. SIMILARITY: CONTAINS 1 ZP DOMAIN.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL X56777; CAA40095.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] A18567; CAA01398.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] MIM 195002; -. GeneCards ZP3B. PRINTS PR00023; ZPELLUCIDA. PROSITE PS00682; ZP_DOMAIN; 1. PFAM PF00100; zona_pellucida; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS Q06633. DOMO Q06633. PROTOMAP Q06633. PRESAGE Q06633. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Glycoprotein; Signal; Sulfatation; Sperm; Receptor; Extracellular matrix; Multigene family.
Features
SIGNAL 1 22 POTENTIAL. CHAIN 23 372 ZONA PELLUCIDA SPERM-BINDING PROTEIN 3B. DOMAIN 45 307 ZP. CARBOHYD 125 125 POTENTIAL. CARBOHYD 147 147 POTENTIAL. CARBOHYD 226 226 POTENTIAL. CARBOHYD 272 272 POTENTIAL. FT table viewer
Sequence information
Length: 372 AA [This is the length of the unprocessed precursor] Molecular weight: 41424 Da [This is the Mw of the unprocessed precursor] CRC64: AB78DB5311BE7B4A [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MELSYRLFIC LLLWGSTELC YPQPLWLLQG GASHPETSVQ PVLVECQEAT LMVMVSKDLF 70 80 90 100 110 120 | | | | | | GTGKLIRAAD LTLGPEACEP LVSMDTEDVV RFEVGLHECG NSMQVTDDAL VYSTFLLHDP 130 140 150 160 170 180 | | | | | | RPVGNLSIVR TNRAEIPIEC RYPRQGNVSS QAILPTWLPF RTTVFSEEKL TFSLRLMEEN 190 200 210 220 230 240 | | | | | | WNAEKRSPTF HLGDAAHLQA EIHTGSHVPL RLFVDHCVAT PTPDQNASPY HTIVDFHGCL 250 260 270 280 290 300 | | | | | | VDGLTDASSA FKVPRPGPDT LQFTVDVFHF ANDSRNMIYI TCHLKVTLAE QDPDELNKAC 310 320 330 340 350 360 | | | | | | SFSKPSNSWF PVEGPADICQ CCNKGDCGTP SHSRRQPHVM SQWSTSASRN RRHVTEEADV 370 | TVGATDLPGQ EW Q06633 in FASTA format