NiceProt View of SWISS-PROT: P21754

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	ZP3A_HUMAN
Primary accession number	P21754
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 18, May 1991
Sequence was last modified in	Release 18, May 1991
Annotations were last modified in	Release 39, February 2000
Name and orig in of the protein
Protein name	ZONA PELLUCIDA SPERM-BINDING PROTEIN 3A [Precursor]
Synonym(s)	ZONA PELLUCIDA GLYCOPROTEIN ZP3A ZONA PELLUCIDA PROTEIN C SPERM RECEPTOR ZP3
Gene name(s)	ZP3A OR ZP3
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. MEDLINE; 90349545. [NCBI, ExPASy, Israel, Japan] Chamberlin M.E., Dean J.; "Human homolog of the mouse sperm receptor."; Proc. Natl. Acad. Sci. U.S.A. 87:6014-6018(1990).
[2] SEQUENCE OF 329-424 FROM N.A. TISSUE=OVARY; MEDLINE; 93122771. [NCBI, ExPASy, Israel, Japan] van Duin M., Polman J.E., Verkoelen C.C., Bunschoten H., Meyerink J.H., Olijve W., Aitken R.J.; "Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations."; Genomics 14:1064-1070(1992).
Comments
FUNCTION: FUNCTIONS AS A SPERM-RECEPTOR. IT IS RESPONSIBLE FOR SPERM-ADHESION TO THE ZONA PELLUCIDA, AND MAY CONTRIBUTE TO THE SPECIES-SPECIFICITY OF THE INSEMINATION. SUBUNIT: ZP3 FORMS WITH ZP1 AND ZP2 THE ZONA PELLUCIDA, IN WHICH ZP2 AND ZP3 COMPLEX INTO COPOLYMERS CROSS-LINKED BY ZP1. SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN. EXTRACELLULAR MATRIX. PTM: SULFATED GLYCOPROTEIN WITH O-LINKED OLIGOSACCHARIDES. SIMILARITY: CONTAINS 1 ZP DOMAIN.
Copyright
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Cross-references
EMBL M60504; AAA61336.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] PIR A36000; A36000. MIM 182889; -. GeneCards ZP3A. PRINTS PR00023; ZPELLUCIDA. PROSITE PS00682; ZP_DOMAIN; 1. PFAM PF00100; zona_pellucida; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS P21754. DOMO P21754. PROTOMAP P21754. PRESAGE P21754. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Glycoprotein; Signal; Sulfatation; Sperm; Receptor; Transmembrane; Extracellular matrix; Multigene family.
Features
SIGNAL 1 22 POTENTIAL. CHAIN 23 424 ZONA PELLUCIDA SPERM-BINDING PROTEIN 3A. DOMAIN 23 387 EXTRACELLULAR (POTENTIAL). TRANSMEM 388 408 POTENTIAL. DOMAIN 409 424 CYTOPLASMIC (POTENTIAL). DOMAIN 45 307 ZP. CARBOHYD 125 125 POTENTIAL. CARBOHYD 147 147 POTENTIAL. CARBOHYD 226 226 POTENTIAL. CARBOHYD 272 272 POTENTIAL. FT table viewer
Sequence information
Length: 424 AA [This is the length of the unprocessed precursor] Molecular weight: 47028 Da [This is the Mw of the unprocessed precursor] CRC64: 94517B7B66EFFE06 [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MELSYRLFIC LLLWGSTELC YPQPLWLLQG GASHPETSVQ PVLVECQEAT LMVMVSKDLF 70 80 90 100 110 120 | | | | | | GTGKLIRAAD LTLGPEACEP LVSMDTEDVV RFEVGLHECG NSMQVTDDAL VYSTFLLHDP 130 140 150 160 170 180 | | | | | | RPVGNLSIVR TNRAEIPIEC RYPRQGNVSS QAILPTWLPF RTTVFSEEKL TFSLRLMEEN 190 200 210 220 230 240 | | | | | | WNAEKRSPTF HLGDAAHLQA EIHTGSHVPL RLFVDHCVAT PTPDQNASPY HTIVDFHGCL 250 260 270 280 290 300 | | | | | | VDGLTDASSA FKVPRPGPDT LQFTVDVFHF ANDSRNMIYI TCHLKVTLAE QDPDELNKAC 310 320 330 340 350 360 | | | | | | SFSKPSNSWF PVEGPADICQ CCNKGDCGTP SHSRRQPHVM SQWSRSASRN RRHVTEEADV 370 380 390 400 410 420 | | | | | | TVGPLIFLDR RGDHEVEQWA LPSDTSVVLL GVGLAVVVSL TLTAVILVLT RRCRTASHPV SASE P21754 in FASTA format