NiceProt View of SWISS-PROT: Q05996

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	ZP2_HUMAN
Primary accession number	Q05996
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 28, February 1994
Sequence was last modified in	Release 28, February 1994
Annotations were last modified in	Release 39, February 2000
Name and orig in of the protein
Protein name	ZONA PELLUCIDA SPERM-BINDING PROTEIN 2 [Precursor]
Synonym(s)	ZONA PELLUCIDA GLYCOPROTEIN ZP2 ZONA PELLUCIDA PROTEIN A
Gene name(s)	ZP2
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. TISSUE=OVARY; MEDLINE; 93215931. [NCBI, ExPASy, Israel, Japan] Liang L.F., Dean J.; "Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes."; Dev. Biol. 156:399-408(1993).
[2] SEQUENCE FROM N.A. Adams M.D., Loftus B.J., Zhou L., Phillips C., Kerlavage A.R., Kim U.J., Venter J.C.; Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
Comments
FUNCTION: ZP2 FORMS WITH ZP1 AND ZP3 THE ZONA PELLUCIDA, IN WHICH ZP2 AND ZP3 COMPLEX INTO COPOLYMERS CROSS-LINKED BY ZP1. ZP2 ACTS AS A SECONDARY SPERM RECEPTOR. SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN. EXTRACELLULAR MATRIX. TISSUE SPECIFICITY: OOCYTES. DEVELOPMENTAL STAGE: EXPRESSED DURING THE 2-WEEK GROWTH PHASE OF OOGENESIS, PRIOR TO OVULATION. PTM: IS PROTEOLYTICALLY CLEAVED AFTER FERTILIZATION, AND THIS MODIFICATION, ALONG WITH PRESUMED CHANGES IN ZP3 MAY PLAY AN IMPORTANT ROLE IN THE POSTFERTILIZATION BLOCK TO POLYSPERMY. PTM: SULFATED GLYCOPROTEIN WITH O-LINKED OLIGOSACCHARIDES (BY SIMILARITY). SIMILARITY: CONTAINS 1 ZP DOMAIN.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL M90366; AAA61335.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] AF001550; AAB67599.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] PIR A48833; A48833. MIM 182888; -. GeneCards ZP2. PRINTS PR00023; ZPELLUCIDA. PROSITE PS00682; ZP_DOMAIN; 1. PFAM PF00100; zona_pellucida; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS Q05996. DOMO Q05996. PROTOMAP Q05996. PRESAGE Q05996. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Glycoprotein; Signal; Sulfatation; Sperm; Receptor; Transmembrane; Extracellular matrix.
Features
SIGNAL 1 38 CHAIN 39 745 ZONA PELLUCIDA SPERM-BINDING PROTEIN 2. DOMAIN 39 716 EXTRACELLULAR (POTENTIAL). TRANSMEM 717 736 POTENTIAL. DOMAIN 737 745 CYTOPLASMIC (POTENTIAL). DOMAIN 370 637 ZP. CARBOHYD 87 87 POTENTIAL. CARBOHYD 105 105 POTENTIAL. CARBOHYD 122 122 POTENTIAL. CARBOHYD 223 223 POTENTIAL. CARBOHYD 269 269 POTENTIAL. CARBOHYD 400 400 POTENTIAL. FT table viewer
Sequence information
Length: 745 AA [This is the length of the unprocessed precursor] Molecular weight: 82356 Da [This is the Mw of the unprocessed precursor] CRC64: 2614DA79738F2CDD [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MACRQRGGSW SPSGWFNAGW STYRSISLFF ALVTSGNSID VSQLVNPAFP GTVTCDEREI 70 80 90 100 110 120 | | | | | | TVEFPSSPGT KKWHASVVDP LGLDMPNCTY ILDPEKLTLR ATYDNCTRRV HGGHQMTIRV 130 140 150 160 170 180 | | | | | | MNNSAALRHG AVMYQFFCPA MQVEETQGLS ASTICQKDFM SFSLPRVFSG LADDSKGTKV 190 200 210 220 230 240 | | | | | | QMGWSIEVGD GARAKTLTLP EAMKEGFSLL IDNHRMTFHV PFNATGVTHY VQGNSHLYMV 250 260 270 280 290 300 | | | | | | SLKLTFISPG QKVIFSSQAI CAPDPVTCNA THMTLTIPEF PGKLKSVSFE NQNIDVSQLH 310 320 330 340 350 360 | | | | | | DNGIDLEATN GMKLHFSKTL LKTKLSEKCL LHQFYLASLK LTFLLRPETV SMVIYPECLC 370 380 390 400 410 420 | | | | | | ESPVSIVTGE LCTQDGFMDV EVYSYQTQPA LDLGTLRVGN SSCQPVFEAQ SQGLVRFHIP 430 440 450 460 470 480 | | | | | | LNGCGTRYKF EDDKVVYENE IHALWTDFPP SKISRDSEFR MTVKCSYSRN DMLLNINVES 490 500 510 520 530 540 | | | | | | LTPPVASVKL GPFTLILQSY PDNSYQQPYG ENEYPLVRFL RQPIYMEVRV LNRDDPNIKL 550 560 570 580 590 600 | | | | | | VLDDCWATST MDPDSFPQWN VVVDGCAYDL DNYQTTFHPV GSSVTHPDHY QRFDMKAFAF 610 620 630 640 650 660 | | | | | | VSEAHVLSSL VYFHCSALIC NRLSPDSPLC SVTCPVSSRH RRATGATEAE KMTVSLPGPI 670 680 690 700 710 720 | | | | | | LLLSDDSSFR GVGSSDLKAS GSSGEKSRSE TGEEVGSRGA MDTKGHKTAG DVGSKAVAAV 730 740 745 | | | AAFAGVVATL GFIYYLYEKR TVSNH Q05996 in FASTA format