NiceProt View of SWISS-PROT: O95096

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	HK22_HUMAN
Primary accession number	O95096
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 38, July 1999
Sequence was last modified in	Release 38, July 1999
Annotations were last modified in	Release 38, July 1999
Name and orig in of the protein
Protein name	HOMEOBOX PROTEIN NKX-2.2
Synonym(s)	None
Gene name(s)	NKX2B OR NKX2.2
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. MEDLINE; 98366900. [NCBI, ExPASy, Israel, Japan] Furuta H., Horikawa Y., Iwasaki N., Hara M., Sussel L., le Beau M.M., Davis E.M., Ogata M., Iwamoto Y., German M.S., Bell G.I.; "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese."; Diabetes 47:1356-1358(1998).
Comments
FUNCTION: MAY BE INVOLVED IN SPECIFYING DIENCEPHALIC NEUROMERIC BOUNDARIES, AND IN CONTROLLING THE EXPRESSION OF GENES THAT PLAY A ROLE IN AXONAL GUIDANCE (BY SIMILARITY). SUBCELLULAR LOCATION: NUCLEAR (PROBABLE). SIMILARITY: BELONGS TO THE NK-2 FAMILY OF HOMEOBOX PROTEINS.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL AF019415; AAC83132.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] AF019414; AAC83132.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] PROSITE PS00027; HOMEOBOX_1; 1. PS50071; HOMEOBOX_2; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS O95096. DOMO O95096. PROTOMAP O95096. PRESAGE O95096. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Homeobox; DNA-binding; Developmental protein; Nuclear protein.
Features
DNA_BIND 128 187 HOMEOBOX. FT table viewer
Sequence information
Length: 273 AA Molecular weight: 30132 Da CRC64: 91BDA220BAFA63D1 [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MSLTNTKTGF SVKDILDLPD TNDEEGSVAE GPEEENEGPE PAKRAGPLGQ GALDAVQSLP 70 80 90 100 110 120 | | | | | | LKNPFYDSSD NPYTRWLAST EGLQYSLHGL AAGAPPQDSS SKSPEPSADE SPDNDKETPG 130 140 150 160 170 180 | | | | | | GGGDAGKKRK RRVLFSKAQT YELERRFRQQ RYLSAPEREH LASLIRLTPT QVKIWFQNHR 190 200 210 220 230 240 | | | | | | YKMKRARAEK GMEVTPLPSP RRVAVPVLVR DGKPCHALKA QDLAAATFQA GIPFSAYSAQ 250 260 270 | | | SLQHMQYNAQ YSSASTPQYP TAHPLVQAQQ WTW O95096 in FASTA format