NiceProt View of SWISS-PROT: P22004

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	BMP6_HUMAN
Primary accession number	P22004
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 19, August 1991
Sequence was last modified in	Release 19, August 1991
Annotations were last modified in	Release 35, November 1997
Name and orig in of the protein
Protein name	BONE MORPHOGENETIC PROTEIN 6 [Precursor]
Synonym(s)	BMP-6
Gene name(s)	BMP6
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. TISSUE=BONE; MEDLINE; 91088608. [NCBI, ExPASy, Israel, Japan] Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M.; "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."; Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990).
Comments
FUNCTION: INDUCES CARTILAGE AND BONE FORMATION. SIMILARITY: BELONGS TO THE TGF-BETA FAMILY.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL M60315; AAA36737.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] PIR B39263; B39263. HSSP P18075; 1BMP. [HSSP ENTRY / SWISS-3DIMAGE / PDB] MIM 112266; -. 193010; -. GeneCards BMP6. PRINTS PR00438; GFCYSKNOT. PROSITE PS00250; TGF_BETA; 1. PFAM PF00019; TGF-beta; 1. PF00688; TGFb_propeptide; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS P22004. DOMO P22004. PROTOMAP P22004. PRESAGE P22004. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Signal; Growth factor; Cytokine; Bone; Cartilage; Glycoprotein.
Features
SIGNAL 1 ? POTENTIAL. PROPEP ? 381 POTENTIAL. CHAIN 382 513 BONE MORPHOGENETIC PROTEIN 6. DISULFID 412 478 BY SIMILARITY. DISULFID 441 510 BY SIMILARITY. DISULFID 445 512 BY SIMILARITY. DISULFID 477 477 INTERCHAIN (BY SIMILARITY). CARBOHYD 241 241 POTENTIAL. CARBOHYD 269 269 POTENTIAL. CARBOHYD 386 386 POTENTIAL. CARBOHYD 404 404 POTENTIAL. CARBOHYD 454 454 POTENTIAL. FT table viewer
Sequence information
Length: 513 AA [This is the length of the unprocessed precursor] Molecular weight: 57225 Da [This is the Mw of the unprocessed precursor] CRC64: 3F19155B36049278 [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MPGLGRRAQW LCWWWGLLCS CCGPPPLRPP LPAAAAAAAG GQLLGDGGSP GRTEQPPPSP 70 80 90 100 110 120 | | | | | | QSSSGFLYRR LKTQEKREMQ KEILSVLGLP HRPRPLHGLQ QPQPPALRQQ EEQQQQQQLP 130 140 150 160 170 180 | | | | | | RGEPPPGRLK SAPLFMLDLY NALSADNDED GASEGERQQS WPHEAASSSQ RRQPPPGAAH 190 200 210 220 230 240 | | | | | | PLNRKSLLAP GSGSGGASPL TSAQDSAFLN DADMVMSFVN LVEYDKEFSP RQRHHKEFKF 250 260 270 280 290 300 | | | | | | NLSQIPEGEV VTAAEFRIYK DCVMGSFKNQ TFLISIYQVL QEHQHRDSDL FLLDTRVVWA 310 320 330 340 350 360 | | | | | | SEEGWLEFDI TATSNLWVVT PQHNMGLQLS VVTRDGVHVH PRAAGLVGRD GPYDKQPFMV 370 380 390 400 410 420 | | | | | | AFFKVSEVHV RTTRSASSRR RQQSRNRSTQ SQDVARVSSA SDYNSSELKT ACRKHELYVS 430 440 450 460 470 480 | | | | | | FQDLGWQDWI IAPKGYAANY CDGECSFPLN AHMNATNHAI VQTLVHLMNP EYVPKPCCAP 490 500 510 | | | TKLNAISVLY FDDNSNVILK KYRNMVVRAC GCH P22004 in FASTA format