NiceProt View of SWISS-PROT: P22003

[General] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

General information about the entry
Entry name	BMP5_HUMAN
Primary accession number	P22003
Secondary accession number(s)	None
Entered in SWISS-PROT in	Release 19, August 1991
Sequence was last modified in	Release 19, August 1991
Annotations were last modified in	Release 33, February 1996
Name and orig in of the protein
Protein name	BONE MORPHOGENETIC PROTEIN 5 [Precursor]
Synonym(s)	BMP-5
Gene name(s)	BMP5
From	Homo sapiens (Human)
Taxonomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
References
[1] SEQUENCE FROM N.A. TISSUE=BONE; MEDLINE; 91088608. [NCBI, ExPASy, Israel, Japan] Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., Wozney J.M.; "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone."; Proc. Natl. Acad. Sci. U.S.A. 87:9843-9847(1990).
Comments
FUNCTION: INDUCES CARTILAGE AND BONE FORMATION. SUBUNIT: HOMODIMER, DISULFIDE-LINKED (BY SIMILARITY). TISSUE SPECIFICITY: EXPRESSED IN THE LUNGS AND LIVER. SIMILARITY: BELONGS TO THE TGF-BETA FAMILY.
Copyright
This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).
Cross-references
EMBL M60314; AAA36736.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] PIR A39263; A39263. HSSP P18075; 1BMP. [HSSP ENTRY / SWISS-3DIMAGE / PDB] MIM 112265; -. GeneCards BMP5. PRINTS PR00438; GFCYSKNOT. PROSITE PS00250; TGF_BETA; 1. PFAM PF00019; TGF-beta; 1. PF00688; TGFb_propeptide; 1. PRODOM [Domain structure / List of seq. sharing at least 1 domain] BLOCKS P22003. DOMO P22003. PROTOMAP P22003. PRESAGE P22003. SWISS-2DPAGE GET REGION ON 2D PAGE.
Keywords
Signal; Growth factor; Cytokine; Bone; Cartilage; Glycoprotein.
Features
SIGNAL 1 ? POTENTIAL. PROPEP ? 322 POTENTIAL. CHAIN 323 454 BONE MORPHOGENETIC PROTEIN 5. DISULFID 353 419 BY SIMILARITY. DISULFID 382 451 BY SIMILARITY. DISULFID 386 453 BY SIMILARITY. DISULFID 418 418 INTERCHAIN (BY SIMILARITY). CARBOHYD 211 211 POTENTIAL. CARBOHYD 327 327 POTENTIAL. CARBOHYD 345 345 POTENTIAL. CARBOHYD 395 395 POTENTIAL. FT table viewer
Sequence information
Length: 454 AA [This is the length of the unprocessed precursor] Molecular weight: 51736 Da [This is the Mw of the unprocessed precursor] CRC64: 631277413CCC22EE [This is a checksum on the sequence]
10 20 30 40 50 60 | | | | | | MHLTVFLLKG IVGFLWSCWV LVGYAKGGLG DNHVHSSFIY RRLRNHERRE IQREILSILG 70 80 90 100 110 120 | | | | | | LPHRPRPFSP GKQASSAPLF MLDLYNAMTN EENPEESEYS VRASLAEETR GARKGYPASP 130 140 150 160 170 180 | | | | | | NGYPRRIQLS RTTPLTTQSP PLASLHDTNF LNDADMVMSF VNLVERDKDF SHQRRHYKEF 190 200 210 220 230 240 | | | | | | RFDLTQIPHG EAVTAAEFRI YKDRSNNRFE NETIKISIYQ IIKEYTNRDA DLFLLDTRKA 250 260 270 280 290 300 | | | | | | QALDVGWLVF DITVTSNHWV INPQNNLGLQ LCAETGDGRS INVKSAGLVG RQGPQSKQPF 310 320 330 340 350 360 | | | | | | MVAFFKASEV LLRSVRAANK RKNQNRNKSS SHQDSSRMSS VGDYNTSEQK QACKKHELYV 370 380 390 400 410 420 | | | | | | SFRDLGWQDW IIAPEGYAAF YCDGECSFPL NAHMNATNHA IVQTLVHLMF PDHVPKPCCA 430 440 450 | | | PTKLNAISVL YFDDSSNVIL KKYRNMVVRS CGCH P22003 in FASTA format