UNSW Embryology

DNA- Human Dystrophin (Swiss-Protein)

Page LinksGeneral informationName and origin ReferencesCross-referencesCommentsFeaturesSequence information

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SWISS-PROT

NiceProt View of SWISS-PROT: P11532

General information about the entry

Entry name

DMD_HUMAN

Primary accession number

P11532

Secondary accession number(s)

Q14169 Q14170

Entered in SWISS-PROT in

Release 12, October 1989

Sequence was last modified in

Release 12, October 1989

Annotations were last modified in

Release 38, April 1999

Name and origin of the protein

Protein name

DYSTROPHIN

Synonym(s)

None

Gene name(s)

DMD

From

HOMO SAPIENS (HUMAN)

Taxonomy

EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA; PRIMATES; CATARRHINI; HOMINIDAE; HOMO.

References

[1]
SEQUENCE FROM N.A.
MEDLINE; 88194521. [NCBI, ExPASy, Israel, Japan]
KOENIG M., MONACO A.P., KUNKEL L.M.;
"The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein.";
CELL 53:219-228(1988).

[2]
SEQUENCE FROM N.A.
MEDLINE; 89345106. [NCBI, ExPASy, Israel, Japan]
ROSENTHAL A., SPEER A., BILLOWITZ H., CROSS G.S., FORREST S.N., DAVIES K.E.;
"Two human cDNA molecules coding for the Duchenne muscular dystrophy (DMD) locus are highly homologous.";
NUCLEIC ACIDS RES. 17:5391-5391(1989).

[3]
SEQUENCE OF 1-497 FROM N.A.
MEDLINE; 87273512. [NCBI, ExPASy, Israel, Japan]
KOENIG M., HOFFMAN E.P., BERTELSON C.J., MONACO A.P., FEENER C., KUNKEL L.M.;
"Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals.";
CELL 50:509-517(1987).

[4]
SEQUENCE OF 404-1137 FROM N.A.
MEDLINE; 88111512. [NCBI, ExPASy, Israel, Japan]
CROSS G.S., SPEER A., ROSENTHAL A., FORREST S.M., SMITH T.J., EDWARDS Y., FLINT T., HILL D., DAVIES K.E.;
"Deletions of fetal and adult muscle cDNA in Duchenne and Becker muscular dystrophy patients.";
EMBO J. 6:3277-3283(1987).

[5]
SEQUENCE OF 665-722; 2098-2204 AND 2305-2366 FROM N.A.
MEDLINE; 89083552. [NCBI, ExPASy, Israel, Japan]
CHAMBERLAIN J.S., GIBBS R.A., RANIER J.A., NGUYEN P.N., CASKEY C.T.;
"Deletion screening of the Duchenne muscular dystrophy locus via multiplex DNA amplification.";
NUCLEIC ACIDS RES. 16:11141-11156(1988).

[6]
SEQUENCE OF 2147-2204 FROM N.A.
MEDLINE; 89345155. [NCBI, ExPASy, Israel, Japan]
BLONDEN L.A.J., DEN DUNNEN J.T., VAN PAASSEN H.M.B., WAPENAAR M.C., GROOTSCHOLTEN P.M., GINJAAR H.B., BAKKER E., PEARSON P.L., VAN OMMEN G.J.B.;
"High resolution deletion breakpoint mapping in the DMD gene by whole cosmid hybridization.";
NUCLEIC ACIDS RES. 17:5611-5621(1989).

[7]
SEQUENCE OF 2305-2364 FROM N.A.
HUTH A., WILL K., SPEER A., BAUER D.;
SUBMITTED (MAR-1991) TO EMBL/GENBANK/DDBJ DATA BANKS.

[8]
REVIEW ON DMD POINT MUTATION VARIANTS.
MEDLINE; 95038763. [NCBI, ExPASy, Israel, Japan]
ROBERTS R.G., GARDNER R.J., BOBROW M.;
"Searching for the 1 in 2,400,000: a review of dystrophin gene point mutations.";
HUM. MUTAT. 4:1-11(1994).

[9]
REVIEW ON VARIANTS.
MEDLINE; 94320940. [NCBI, ExPASy, Israel, Japan]
RININSLAND F., REISS J.;
"Microlesions and polymorphisms in the Duchenne/Becker muscular dystrophy gene.";
HUM. GENET. 94:111-116(1994).

[10]
VARIANT DMD ARG-54.
MEDLINE; 94004962. [NCBI, ExPASy, Israel, Japan]
PRIOR T.W., PAPP A.C., SNYDER P.J., BURGHES A.H.M., BARTOLO C., SEDRA M.S., WESTERN L.M., MENDELL J.R.;
"A missense mutation in the dystrophin gene in a Duchenne muscular dystrophy patient.";
NAT. GENET. 4:357-360(1993).

[11]
VARIANTS DMD HIS-365; TRP-2191 AND ARG-2937.
MEDLINE; 95152525. [NCBI, ExPASy, Israel, Japan]
NIGRO V., NIGRO G., ESPOSITO M.G., COMI L.I., MOLINARI A.M., PUCA G.A., POLITANO L.;
"Novel small mutations along the DMD/BMD gene associated with different phenotypes.";
HUM. MOL. GENET. 3:1907-1908(1994).

[12]
ALTERNATIVE SPLICING (DYSTROPHIN-1 AND -2).
TISSUE=RETINA;
WHITE R.A.;
SUBMITTED (JAN-1996) TO EMBL/GENBANK/DDBJ DATA BANKS.

[13]
ALTERNATIVE SPLICING (DYSTROPHIN-3).
TISSUE=BRAIN;
MEDLINE; 89181947. [NCBI, ExPASy, Israel, Japan]
FEENER C.A., KOENIG M., KUNKEL L.M.;
"Alternative splicing of human dystrophin mRNA generates isoforms at the carboxy terminus.";
NATURE 338:509-511(1989).

Comments
  • FUNCTION: MAY PLAY A ROLE IN ANCHORING THE CYTOSKELETON TO THE PLASMA MEMBRANE.
  • DISEASE: DYSTROPHIN IS DEFECTIVE IN DUCHENNE MUSCULAR DYSTROPHY (DMD) AND BECKER MUSCULAR DISTROPHY (BMD). DMD IS THE MOST COMMON FORM OF MUSCULAR DYSTROPHY. A SEX-LINKED RECESSIVE DISORDER. IT TYPICALLY PRESENTS IN BOYS AGED 3 TO 7 YR AS PROXIMAL MUSCLE WEAKNESS CAUSING WADDLING GAIT, TOE-WALKING, LORDOSIS, FREQUENT FALLS, AND DIFFICULTY IN STANDING UP AND CLIMBING UP STAIRS. THE PELVIC GIRDLE IS AFFECTED FIRST, THEN THE SHOULDER GIRDLE. PROGRESSION IS STEADY AND MOST PATIENTS ARE CONFINED TO A WHEELCHAIR BY AGE OF 10 OR 12. FLEXION CONTRACTURES AND SCOLIOSIS ULTIMATELY OCCUR. ABOUT 50% OF PATIENTS HAVE A LOWER IQ THAN THEIR GENETIC EXPECTATIONS WOULD SUGGEST. THERE IS NO TREATMENT. BMD RESSEMBLES DMD IN HEREDITARY AND CLINICAL FEATURES BUT IS LATER IN ONSET AND MORE BENIGN.
  • THE DMD GENE IS THE LARGEST KNOWN GENE IN HUMANS. IT IS 2.4 MILLION BASE-PAIRS IN SIZE AND COMPRISES 79 EXONS.
  • ALTERNATIVE PRODUCTS: AT LEAST 4 ISOFORMS ARE PRODUCED BY ALTERNATIVE SPLICING; THE 3 SHORTER VARIANTS ARE CALLED DYSTROPHIN-1, -2 AND -3.
  • SIMILARITY: THE ACTIN-BINDING DOMAIN IS OF A TYPE FOUND IN MANY ACTIN-BINDING PROTEINS (SUCH AS ACTININ, DYSTROPHIN, FIMBRIN, ABP-120, ABP-180, OR BETA-FODRIN).
  • SIMILARITY: CONTAINS 1 WW DOMAIN.

Copyright

This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.isb-sib.ch/announce/ or send an email to license@isb-sib.ch).

Cross-references

EMBL

X06179; G30840; ALT_SEQ. [EMBL / GenBank / DDBJ] [CoDingSequence]
X06178; G30837; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
X14298; G30846; ALT_SEQ. [EMBL / GenBank / DDBJ] [CoDingSequence]
X15495; E20865; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
X54820; G30842; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
X13045; E3996; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
X13046; G809549; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
X13047; E15313; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
X13048; E15311; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
U27203; G1171132; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
U27203; G1171133; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
X15148; G30939; -. [EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A27605; A27605.
A27162; A27162.
S05291; S05291.

MIM

310200; -.
302045; -.

GeneCard

GeneCard; DMD.

PROSITE

PS00019; ACTININ_1; 1.
PS00020; ACTININ_2; 1.
PS01159; WW_DOMAIN_1; 1.
PS50020; WW_DOMAIN_2; 1.

PFAM

PF00307; actinin-binding; 1.
PF00397; WW_rsp5_WWP; 1.
PF00435; spectrin; 21.
PF00569; ZZ; 1.

HSSP

Q01082; 1AA2. [HSSP ENTRY / SWISS-3DIMAGE / PDB-ENTRY / PDB-RASMOL / PDB-3DIMAGE]

DOMO

P11532.

PRODOM

[Domain structure / List of seq. sharing at least 1 domain]

PROTOMAP

P11532.

PRESAGE

P11532.

SWISS-2DPAGE

GET REGION ON 2D PAGE.

Keywords

STRUCTURAL PROTEIN; ACTIN-BINDING; CALCIUM-BINDING; CYTOSKELETON; REPEAT; DISEASE MUTATION; ALTERNATIVE SPLICING.

Features

 


DOMAIN        1    240       ACTIN-BINDING.
                           
DOMAIN      300   3000       26 SPECTRIN-LIKE REPEATS.
                           
DOMAIN     3055   3088       WW DOMAIN.
                           
DOMAIN     3089   3360       CYS-RICH.
                           
VARIANT      32     62       MISSING (IN BMD).
                           
VARIANT      54     54       L -> R (IN DMD).
                           
VARIANT     133    133       Q -> P.
                           
VARIANT     168    168       A -> D (IN BMD).
                           
VARIANT     231    231       Y -> N (IN BMD).
                           
VARIANT     365    365       Q -> H.
                           
VARIANT     495    534       MISSING (IN BMD).
                           
VARIANT     623    623       L -> I.
                           
VARIANT     773    773       K -> E (IN DMD).
                           
VARIANT     784    784       A -> G.
                           
VARIANT     882    882       G -> D.
                           
VARIANT    1197   1197       V -> F.
                           
VARIANT    1245   1245       T -> I.
                           
VARIANT    1278   1278       A -> P.
                           
VARIANT    1377   1377       K -> N.
                           
VARIANT    1469   1469       L -> Q.
                           
VARIANT    1745   1745       R -> H.
                           
VARIANT    1844   1844       R -> S.
                           
VARIANT    2155   2155       R -> W.
                           
VARIANT    2191   2191       R -> W.
                           
VARIANT    2305   2366       MISSING (IN DMD).
                           
VARIANT    2366   2366       Q -> K.
                           
VARIANT    2910   2910       E -> V (IN DMD).
                           
VARIANT    2912   2912       N -> D (IN DMD).
                           
VARIANT    2921   2921       H -> R (IN BMD).
                           
VARIANT    2937   2937       Q -> R.
                           
VARIANT    3421   3421       A -> V (IN BMD).
                           
VARSPLIC      1      1       M -> MTEIILLIFFPAYFLN (IN DYSTROPHIN-1).
                           
VARSPLIC      2   1357       MISSING (IN DYSTROPHIN-1).
                           
VARSPLIC      1      1       M -> MSARKLRNLSYKK (IN DYSTROPHIN-2).
                           
VARSPLIC      2   1357       MISSING (IN DYSTROPHIN-2).
                           
VARSPLIC      1     11       MLWWEEVEDCY -> MED (IN DYSTROPHIN-3).
                           
CONFLICT    664    664       Q -> QM (IN REF. 4).
                           
CONFLICT   2361   2361       G -> E (IN REF. 7).
SEVIEWER logo FT table viewer

Sequence information

Length: 3685 AA

Molecular weight: 426669 Da

CRC32: F3703386 [This is a checksum on the sequence]

 

        10         20         30         40         50         60 
         |          |          |          |          |          | 
MLWWEEVEDC YEREDVQKKT FTKWVNAQFS KFGKQHIENL FSDLQDGRRL LDLLEGLTGQ
                           
        70         80         90        100        110        120 
         |          |          |          |          |          | 
KLPKEKGSTR VHALNNVNKA LRVLQNNNVD LVNIGSTDIV DGNHKLTLGL IWNIILHWQV
                           
       130        140        150        160        170        180 
         |          |          |          |          |          | 
KNVMKNIMAG LQQTNSEKIL LSWVRQSTRN YPQVNVINFT TSWSDGLALN ALIHSHRPDL
                           
       190        200        210        220        230        240 
         |          |          |          |          |          | 
FDWNSVVCQQ SATQRLEHAF NIARYQLGIE KLLDPEDVDT TYPDKKSILM YITSLFQVLP
                           
       250        260        270        280        290        300 
         |          |          |          |          |          | 
QQVSIEAIQE VEMLPRPPKV TKEEHFQLHH QMHYSQQITV SLAQGYERTS SPKPRFKSYA
                           
       310        320        330        340        350        360 
         |          |          |          |          |          | 
YTQAAYVTTS DPTRSPFPSQ HLEAPEDKSF GSSLMESEVN LDRYQTALEE VLSWLLSAED
                           
       370        380        390        400        410        420 
         |          |          |          |          |          | 
TLQAQGEISN DVEVVKDQFH THEGYMMDLT AHQGRVGNIL QLGSKLIGTG KLSEDEETEV
                           
       430        440        450        460        470        480 
         |          |          |          |          |          | 
QEQMNLLNSR WECLRVASME KQSNLHRVLM DLQNQKLKEL NDWLTKTEER TRKMEEEPLG
                           
       490        500        510        520        530        540 
         |          |          |          |          |          | 
PDLEDLKRQV QQHKVLQEDL EQEQVRVNSL THMVVVVDES SGDHATAALE EQLKVLGDRW
                           
       550        560        570        580        590        600 
         |          |          |          |          |          | 
ANICRWTEDR WVLLQDILLK WQRLTEEQCL FSAWLSEKED AVNKIHTTGF KDQNEMLSSL
                           
       610        620        630        640        650        660 
         |          |          |          |          |          | 
QKLAVLKADL EKKKQSMGKL YSLKQDLLST LKNKSVTQKT EAWLDNFARC WDNLVQKLEK
                           
       670        680        690        700        710        720 
         |          |          |          |          |          | 
STAQISQAVT TTQPSLTQTT VMETVTTVTT REQILVKHAQ EELPPPPPQK KRQITVDSEI
                           
       730        740        750        760        770        780 
         |          |          |          |          |          | 
RKRLDVDITE LHSWITRSEA VLQSPEFAIF RKEGNFSDLK EKVNAIEREK AEKFRKLQDA
                           
       790        800        810        820        830        840 
         |          |          |          |          |          | 
SRSAQALVEQ MVNEGVNADS IKQASEQLNS RWIEFCQLLS ERLNWLEYQN NIIAFYNQLQ
                           
       850        860        870        880        890        900 
         |          |          |          |          |          | 
QLEQMTTTAE NWLKIQPTTP SEPTAIKSQL KICKDEVNRL SGLQPQIERL KIQSIALKEK
                           
       910        920        930        940        950        960 
         |          |          |          |          |          | 
GQGPMFLDAD FVAFTNHFKQ VFSDVQAREK ELQTIFDTLP PMRYQETMSA IRTWVQQSET
                           
       970        980        990       1000       1010       1020 
         |          |          |          |          |          | 
KLSIPQLSVT DYEIMEQRLG ELQALQSSLQ EQQSGLYYLS TTVKEMSKKA PSEISRKYQS
                           
      1030       1040       1050       1060       1070       1080 
         |          |          |          |          |          | 
EFEEIEGRWK KLSSQLVEHC QKLEEQMNKL RKIQNHIQTL KKWMAEVDVF LKEEWPALGD
                           
      1090       1100       1110       1120       1130       1140 
         |          |          |          |          |          | 
SEILKKQLKQ CRLLVSDIQT IQPSLNSVNE GGQKIKNEAE PEFASRLETE LKELNTQWDH
                           
      1150       1160       1170       1180       1190       1200 
         |          |          |          |          |          | 
MCQQVYARKE ALKGGLEKTV SLQKDLSEMH EWMTQAEEEY LERDFEYKTP DELQKAVEEM
                           
      1210       1220       1230       1240       1250       1260 
         |          |          |          |          |          | 
KRAKEEAQQK EAKVKLLTES VNSVIAQAPP VAQEALKKEL ETLTTNYQWL CTRLNGKCKT
                           
      1270       1280       1290       1300       1310       1320 
         |          |          |          |          |          | 
LEEVWACWHE LLSYLEKANK WLNEVEFKLK TTENIPGGAE EISEVLDSLE NLMRHSEDNP
                           
      1330       1340       1350       1360       1370       1380 
         |          |          |          |          |          | 
NQIRILAQTL TDGGVMDELI NEELETFNSR WRELHEEAVR RQKLLEQSIQ SAQETEKSLH
                           
      1390       1400       1410       1420       1430       1440 
         |          |          |          |          |          | 
LIQESLTFID KQLAAYIADK VDAAQMPQEA QKIQSDLTSH EISLEEMKKH NQGKEAAQRV
                           
      1450       1460       1470       1480       1490       1500 
         |          |          |          |          |          | 
LSQIDVAQKK LQDVSMKFRL FQKPANFELR LQESKMILDE VKMHLPALET KSVEQEVVQS
                           
      1510       1520       1530       1540       1550       1560 
         |          |          |          |          |          | 
QLNHCVNLYK SLSEVKSEVE MVIKTGRQIV QKKQTENPKE LDERVTALKL HYNELGAKVT
                           
      1570       1580       1590       1600       1610       1620 
         |          |          |          |          |          | 
ERKQQLEKCL KLSRKMRKEM NVLTEWLAAT DMELTKRSAV EGMPSNLDSE VAWGKATQKE
                           
      1630       1640       1650       1660       1670       1680 
         |          |          |          |          |          | 
IEKQKVHLKS ITEVGEALKT VLGKKETLVE DKLSLLNSNW IAVTSRAEEW LNLLLEYQKH
                           
      1690       1700       1710       1720       1730       1740 
         |          |          |          |          |          | 
METFDQNVDH ITKWIIQADT LLDESEKKKP QQKEDVLKRL KAELNDIRPK VDSTRDQAAN
                           
      1750       1760       1770       1780       1790       1800 
         |          |          |          |          |          | 
LMANRGDHCR KLVEPQISEL NHRFAAISHR IKTGKASIPL KELEQFNSDI QKLLEPLEAE
                           
      1810       1820       1830       1840       1850       1860 
         |          |          |          |          |          | 
IQQGVNLKEE DFNKDMNEDN EGTVKELLQR GDNLQQRITD ERKREEIKIK QQLLQTKHNA
                           
      1870       1880       1890       1900       1910       1920 
         |          |          |          |          |          | 
LKDLRSQRRK KALEISHQWY QYKRQADDLL KCLDDIEKKL ASLPEPRDER KIKEIDRELQ
                           
      1930       1940       1950       1960       1970       1980 
         |          |          |          |          |          | 
KKKEELNAVR RQAEGLSEDG AAMAVEPTQI QLSKRWREIE SKFAQFRRLN FAQIHTVREE
                           
      1990       2000       2010       2020       2030       2040 
         |          |          |          |          |          | 
TMMVMTEDMP LEISYVPSTY LTEITHVSQA LLEVEQLLNA PDLCAKDFED LFKQEESLKN
                           
      2050       2060       2070       2080       2090       2100 
         |          |          |          |          |          | 
IKDSLQQSSG RIDIIHSKKT AALQSATPVE RVKLQEALSQ LDFQWEKVNK MYKDRQGRFD
                           
      2110       2120       2130       2140       2150       2160 
         |          |          |          |          |          | 
RSVEKWRRFH YDIKIFNQWL TEAEQFLRKT QIPENWEHAK YKWYLKELQD GIGQRQTVVR
                           
      2170       2180       2190       2200       2210       2220 
         |          |          |          |          |          | 
TLNATGEEII QQSSKTDASI LQEKLGSLNL RWQEVCKQLS DRKKRLEEQK NILSEFQRDL
                           
      2230       2240       2250       2260       2270       2280 
         |          |          |          |          |          | 
NEFVLWLEEA DNIASIPLEP GKEQQLKEKL EQVKLLVEEL PLRQGILKQL NETGGPVLVS
                           
      2290       2300       2310       2320       2330       2340 
         |          |          |          |          |          | 
APISPEEQDK LENKLKQTNL QWIKVSRALP EKQGEIEAQI KDLGQLEKKL EDLEEQLNHL
                           
      2350       2360       2370       2380       2390       2400 
         |          |          |          |          |          | 
LLWLSPIRNQ LEIYNQPNQE GPFDVQETEI AVQAKQPDVE EILSKGQHLY KEKPATQPVK
                           
      2410       2420       2430       2440       2450       2460 
         |          |          |          |          |          | 
RKLEDLSSEW KAVNRLLQEL RAKQPDLAPG LTTIGASPTQ TVTLVTQPVV TKETAISKLE
                           
      2470       2480       2490       2500       2510       2520 
         |          |          |          |          |          | 
MPSSLMLEVP ALADFNRAWT ELTDWLSLLD QVIKSQRVMV GDLEDINEMI IKQKATMQDL
                           
      2530       2540       2550       2560       2570       2580 
         |          |          |          |          |          | 
EQRRPQLEEL ITAAQNLKNK TSNQEARTII TDRIERIQNQ WDEVQEHLQN RRQQLNEMLK
                           
      2590       2600       2610       2620       2630       2640 
         |          |          |          |          |          | 
DSTQWLEAKE EAEQVLGQAR AKLESWKEGP YTVDAIQKKI TETKQLAKDL RQWQTNVDVA
                           
      2650       2660       2670       2680       2690       2700 
         |          |          |          |          |          | 
NDLALKLLRD YSADDTRKVH MITENINASW RSIHKRVSER EAALEETHRL LQQFPLDLEK
                           
      2710       2720       2730       2740       2750       2760 
         |          |          |          |          |          | 
FLAWLTEAET TANVLQDATR KERELEDSKG VKELMKQWQD LQGEIEAHTD VYHNLDENSQ
                           
      2770       2780       2790       2800       2810       2820 
         |          |          |          |          |          | 
KILRSLEGSD DAVLLQRRLD NMNFKWSLLR KKSLNIRSHL EASSDQWKRL HLSLQELLVW
                           
      2830       2840       2850       2860       2870       2880 
         |          |          |          |          |          | 
LQLKDDELSR QAPIGGDFPA VQKQNDVHRA FKRELKTKEP VIMSTLETVR IFLTEQPLEG
                           
      2890       2900       2910       2920       2930       2940 
         |          |          |          |          |          | 
LEKLYQEPRE LPPEERAQNV TRLLRKQAEE VNTEWEKLNL HSADWQRKID ETLERLQELQ
                           
      2950       2960       2970       2980       2990       3000 
         |          |          |          |          |          | 
EATDELDLKL RQAEVIKGSW QPVGDLLIDS LQDHLEKVKA LRGEIAPLKE NVSHVNDLAR
                           
      3010       3020       3030       3040       3050       3060 
         |          |          |          |          |          | 
QLTTLGIQLS PYNLSTLEDL NTRWKLLQVA VEDRVRQLHE AHRDFGPASQ HFLSTSVQGP
                           
      3070       3080       3090       3100       3110       3120 
         |          |          |          |          |          | 
WERAISPNKV PYYINHETQT TCWDHPKMTE LYQSLADLNN VRFSAYRTAM KLRRLQKALC
                           
      3130       3140       3150       3160       3170       3180 
         |          |          |          |          |          | 
LDLLSLSAAC DALDQHNLKQ NDQPMDILQI INCLTTIYDR LEQEHNNLVN VPLCVDMCLN
                           
      3190       3200       3210       3220       3230       3240 
         |          |          |          |          |          | 
WLLNVYDTGR TGRIRVLSFK TGIISLCKAH LEDKYRYLFK QVASSTGFCD QRRLGLLLHD
                           
      3250       3260       3270       3280       3290       3300 
         |          |          |          |          |          | 
SIQIPRQLGE VASFGGSNIE PSVRSCFQFA NNKPEIEAAL FLDWMRLEPQ SMVWLPVLHR
                           
      3310       3320       3330       3340       3350       3360 
         |          |          |          |          |          | 
VAAAETAKHQ AKCNICKECP IIGFRYRSLK HFNYDICQSC FFSGRVAKGH KMHYPMVEYC
                           
      3370       3380       3390       3400       3410       3420 
         |          |          |          |          |          | 
TPTTSGEDVR DFAKVLKNKF RTKRYFAKHP RMGYLPVQTV LEGDNMETPV TLINFWPVDS
                           
      3430       3440       3450       3460       3470       3480 
         |          |          |          |          |          | 
APASSPQLSH DDTHSRIEHY ASRLAEMENS NGSYLNDSIS PNESIDDEHL LIQHYCQSLN
                           
      3490       3500       3510       3520       3530       3540 
         |          |          |          |          |          | 
QDSPLSQPRS PAQILISLES EERGELERIL ADLEEENRNL QAEYDRLKQQ HEHKGLSPLP
                           
      3550       3560       3570       3580       3590       3600 
         |          |          |          |          |          | 
SPPEMMPTSP QSPRDAELIA EAKLLRQHKG RLEARMQILE DHNKQLESQL HRLRQLLEQP
                           
      3610       3620       3630       3640       3650       3660 
         |          |          |          |          |          | 
QAEAKVNGTT VSSPSTSLQR SDSSQPMLLR VVGSQTSDSM GEEDLLSPPQ DTSTGLEEVM
                           
      3670       3680  3685 
         |          |     |
EQLNNSFPSS RGRNTPGKPM REDTM

 

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P11532 in FASTA format

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Date Last Modified: 11/3/99
This site maintained by Dr M. Hill