UNSW Embryology
DNA- Human Dystrophin (Genbank)
Page LinksLOCUSACCESSIONSOURCEREFERENCEFEATUREStranslation sequence See: Swiss-Protein Dystrophin Entry	Intro | Genes and Diseases | Databanks | Genetic Codes | Dev Genes | Genomes
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LOCUS DMD 13956 bp mRNA PRI 31-MAR-1999 DEFINITION Homo sapiens dystrophin (muscular dystrophy, Duchenne and Becker types), includes DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272 (DMD) mRNA. ACCESSION NM_000109 NID g4503344 VERSION NM_000109.1 GI:4503344 KEYWORDS . SOURCE human. ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1699) AUTHORS Koenig,M., Hoffman,E.P., Bertelson,C.J., Monaco,A.P., Feener,C. and Kunkel,L.M. TITLE Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals JOURNAL Cell 50 (3), 509-517 (1987) MEDLINE 87273512 REFERENCE 2 (bases 1678 to 3830) AUTHORS Hoffman,E.P., Monaco,A.P., Feener,C.C. and Kunkel,L.M. TITLE Conservation of the Duchenne muscular dystrophy gene in mice and humans JOURNAL Science 238 (4825), 347-350 (1987) MEDLINE 88018015 REFERENCE 3 (bases 1 to 13956) AUTHORS Koenig,M., Monaco,A.P. and Kunkel,L.M. TITLE The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein JOURNAL Cell 53 (2), 219-226 (1988) MEDLINE 88194521 COMMENT REFSEQ: This reference sequence was derived from M18533. Draft entry and computer-readable sequence for [1],[2],[3] kindly provided by M.Koenig, 01-APR-1988 The severity of muscular dystrophy is determined by the size of the deleted DNA segment. Deletions found in different patients were from positions 302-2200, 473-1168, 1691-1810, and 1169-3011. PROVISIONAL RefSeq: This is a provisional reference sequence record that has not yet been subject to human review. The final curated reference sequence record may be somewhat different from this one. FEATURES Location/Qualifiers source 1..13956 /organism="Homo sapiens" /db_xref="taxon:9606" /map="Xp21.3-p21.1" gene 1..13956 /gene="DMD" /note="BMD" /db_xref="MIM:310200" /db_xref="LocusID:1756" CDS 209..11266 /gene="DMD" /codon_start=1 /product="dystrophin" /protein_id="NP_000100.1" /db_xref="PID:g4503345" /db_xref="GI:4503345" /translation="MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDL QDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDG NHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFT TSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDV DTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQ QITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSL MESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH QGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM DLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTE EQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLK QDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVM ETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEA VLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNA DSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAF TNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDY EIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWK KLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQL KQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVY ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAK EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLE EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNP NQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEA AQRVLSQIDVAQKKLQDVSMKFRLFQKPANFELRLQESKMILDEVKMHLPALETKSVE QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY NELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAE EWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELND IRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELE QFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER KREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL ASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE IESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQ LLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNL RWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKE KLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVS RALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRA KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLK NKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL GQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTA NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL TTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKA LCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVD MCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRL GLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSM VWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGH KMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET PVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESID DEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEY DRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDH NKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSM GEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM" BASE COUNT 4602 a 2780 c 3122 g 3452 t ORIGIN 1 gggattccct cactttcccc ctacaggact cagatctggg aggcaattac cttcggagaa 61 aaacgaatag gaaaaactga agtgttactt tttttaaagc tgctgaagtt tgttggtttc 121 tcattgtttt taagcctact ggagcaataa agtttgaaga acttttacca ggtttttttt 181 atcgctgcct tgatatacac ttttcaaaat gctttggtgg gaagaagtag aggactgtta 241 tgaaagagaa gatgttcaaa agaaaacatt cacaaaatgg gtaaatgcac aattttctaa 301 gtttgggaag cagcatattg agaacctctt cagtgaccta caggatggga ggcgcctcct 361 agacctcctc gaaggcctga cagggcaaaa actgccaaaa gaaaaaggat ccacaagagt 421 tcatgccctg aacaatgtca acaaggcact gcgggttttg cagaacaata atgttgattt 481 agtgaatatt ggaagtactg acatcgtaga tggaaatcat aaactgactc ttggtttgat 541 ttggaatata atcctccact ggcaggtcaa aaatgtaatg aaaaatatca tggctggatt 601 gcaacaaacc aacagtgaaa agattctcct gagctgggtc cgacaatcaa ctcgtaatta 661 tccacaggtt aatgtaatca acttcaccac cagctggtct gatggcctgg ctttgaatgc 721 tctcatccat agtcataggc cagacctatt tgactggaat agtgtggttt gccagcagtc 781 agccacacaa cgactggaac atgcattcaa catcgccaga tatcaattag gcatagagaa 841 actactcgat cctgaagatg ttgataccac ctatccagat aagaagtcca tcttaatgta 901 catcacatca ctcttccaag ttttgcctca acaagtgagc attgaagcca tccaggaagt 961 ggaaatgttg ccaaggccac ctaaagtgac taaagaagaa cattttcagt tacatcatca 1021 aatgcactat tctcaacaga tcacggtcag tctagcacag ggatatgaga gaacttcttc 1081 ccctaagcct cgattcaaga gctatgccta cacacaggct gcttatgtca ccacctctga 1141 ccctacacgg agcccatttc cttcacagca tttggaagct cctgaagaca agtcatttgg 1201 cagttcattg atggagagtg aagtaaacct ggaccgttat caaacagctt tagaagaagt 1261 attatcgtgg cttctttctg ctgaggacac attgcaagca caaggagaga tttctaatga 1321 tgtggaagtg gtgaaagacc agtttcatac tcatgagggg tacatgatgg atttgacagc 1381 ccatcagggc cgggttggta atattctaca attgggaagt aagctgattg gaacaggaaa 1441 attatcagaa gatgaagaaa ctgaagtaca agagcagatg aatctcctaa attcaagatg 1501 ggaatgcctc agggtagcta gcatggaaaa acaaagcaat ttacatagag ttttaatgga 1561 tctccagaat cagaaactga aagagttgaa tgactggcta acaaaaacag aagaaagaac 1621 aaggaaaatg gaggaagagc ctcttggacc tgatcttgaa gacctaaaac gccaagtaca 1681 acaacataag gtgcttcaag aagatctaga acaagaacaa gtcagggtca attctctcac 1741 tcacatggtg gtggtagttg atgaatctag tggagatcac gcaactgctg ctttggaaga 1801 acaacttaag gtattgggag atcgatgggc aaacatctgt agatggacag aagaccgctg 1861 ggttctttta caagacatcc ttctcaaatg gcaacgtctt actgaagaac agtgcctttt 1921 tagtgcatgg ctttcagaaa aagaagatgc agtgaacaag attcacacaa ctggctttaa 1981 agatcaaaat gaaatgttat caagtcttca aaaactggcc gttttaaaag cggatctaga 2041 aaagaaaaag caatccatgg gcaaactgta ttcactcaaa caagatcttc tttcaacact 2101 gaagaataag tcagtgaccc agaagacgga agcatggctg gataactttg cccggtgttg 2161 ggataattta gtccaaaaac ttgaaaagag tacagcacag atttcacagg ctgtcaccac 2221 cactcagcca tcactaacac agacaactgt aatggaaaca gtaactacgg tgaccacaag 2281 ggaacagatc ctggtaaagc atgctcaaga ggaacttcca ccaccacctc cccaaaagaa 2341 gaggcagatt actgtggatt ctgaaattag gaaaaggttg gatgttgata taactgaact 2401 tcacagctgg attactcgct cagaagctgt gttgcagagt cctgaatttg caatctttcg 2461 gaaggaaggc aacttctcag acttaaaaga aaaagtcaat gccatagagc gagaaaaagc 2521 tgagaagttc agaaaactgc aagatgccag cagatcagct caggccctgg tggaacagat 2581 ggtgaatgag ggtgttaatg cagatagcat caaacaagcc tcagaacaac tgaacagccg 2641 gtggatcgaa ttctgccagt tgctaagtga gagacttaac tggctggagt atcagaacaa 2701 catcatcgct ttctataatc agctacaaca attggagcag atgacaacta ctgctgaaaa 2761 ctggttgaaa atccaaccca ccaccccatc agagccaaca gcaattaaaa gtcagttaaa 2821 aatttgtaag gatgaagtca accggctatc aggtcttcaa cctcaaattg aacgattaaa 2881 aattcaaagc atagccctga aagagaaagg acaaggaccc atgttcctgg atgcagactt 2941 tgtggccttt acaaatcatt ttaagcaagt cttttctgat gtgcaggcca gagagaaaga 3001 gctacagaca atttttgaca ctttgccacc aatgcgctat caggagacca tgagtgccat 3061 caggacatgg gtccagcagt cagaaaccaa actctccata cctcaactta gtgtcaccga 3121 ctatgaaatc atggagcaga gactcgggga attgcaggct ttacaaagtt ctctgcaaga 3181 gcaacaaagt ggcctatact atctcagcac cactgtgaaa gagatgtcga agaaagcgcc 3241 ctctgaaatt agccggaaat atcaatcaga atttgaagaa attgagggac gctggaagaa 3301 gctctcctcc cagctggttg agcattgtca aaagctagag gagcaaatga ataaactccg 3361 aaaaattcag aatcacatac aaaccctgaa gaaatggatg gctgaagttg atgtttttct 3421 gaaggaggaa tggcctgccc ttggggattc agaaattcta aaaaagcagc tgaaacagtg 3481 cagactttta gtcagtgata ttcagacaat tcagcccagt ctaaacagtg tcaatgaagg 3541 tgggcagaag ataaagaatg aagcagagcc agagtttgct tcgagacttg agacagaact 3601 caaagaactt aacactcagt gggatcacat gtgccaacag gtctatgcca gaaaggaggc 3661 cttgaaggga ggtttggaga aaactgtaag cctccagaaa gatctatcag agatgcacga 3721 atggatgaca caagctgaag aagagtatct tgagagagat tttgaatata aaactccaga 3781 tgaattacag aaagcagttg aagagatgaa gagagctaaa gaagaggccc aacaaaaaga 3841 agcgaaagtg aaactcctta ctgagtctgt aaatagtgtc atagctcaag ctccacctgt 3901 agcacaagag gccttaaaaa aggaacttga aactctaacc accaactacc agtggctctg 3961 cactaggctg aatgggaaat gcaagacttt ggaagaagtt tgggcatgtt ggcatgagtt 4021 attgtcatac ttggagaaag caaacaagtg gctaaatgaa gtagaattta aacttaaaac 4081 cactgaaaac attcctggcg gagctgagga aatctctgag gtgctagatt cacttgaaaa 4141 tttgatgcga cattcagagg ataacccaaa tcagattcgc atattggcac agaccctaac 4201 agatggcgga gtcatggatg agctaatcaa tgaggaactt gagacattta attctcgttg 4261 gagggaacta catgaagagg ctgtaaggag gcaaaagttg cttgaacaga gcatccagtc 4321 tgcccaggag actgaaaaat ccttacactt aatccaggag tccctcacat tcattgacaa 4381 gcagttggca gcttatattg cagacaaggt ggacgcagct caaatgcctc aggaagccca 4441 gaaaatccaa tctgatttga caagtcatga gatcagttta gaagaaatga agaaacataa 4501 tcaggggaag gaggctgccc aaagagtcct gtctcagatt gatgttgcac agaaaaaatt 4561 acaagatgtc tccatgaagt ttcgattatt ccagaaacca gccaattttg agctgcgtct 4621 acaagaaagt aagatgattt tagatgaagt gaagatgcac ttgcctgcat tggaaacaaa 4681 gagtgtggaa caggaagtag tacagtcaca gctaaatcat tgtgtgaact tgtataaaag 4741 tctgagtgaa gtgaagtctg aagtggaaat ggtgataaag actggacgtc agattgtaca 4801 gaaaaagcag acggaaaatc ccaaagaact tgatgaaaga gtaacagctt tgaaattgca 4861 ttataatgag ctgggagcaa aggtaacaga aagaaagcaa cagttggaga aatgcttgaa 4921 attgtcccgt aagatgcgaa aggaaatgaa tgtcttgaca gaatggctgg cagctacaga 4981 tatggaattg acaaagagat cagcagttga aggaatgcct agtaatttgg attctgaagt 5041 tgcctgggga aaggctactc aaaaagagat tgagaaacag aaggtgcacc tgaagagtat 5101 cacagaggta ggagaggcct tgaaaacagt tttgggcaag aaggagacgt tggtggaaga 5161 taaactcagt cttctgaata gtaactggat agctgtcacc tcccgagcag aagagtggtt 5221 aaatcttttg ttggaatacc agaaacacat ggaaactttt gaccagaatg tggaccacat 5281 cacaaagtgg atcattcagg ctgacacact tttggatgaa tcagagaaaa agaaacccca 5341 gcaaaaagaa gacgtgctta agcgtttaaa ggcagaactg aatgacatac gcccaaaggt 5401 ggactctaca cgtgaccaag cagcaaactt gatggcaaac cgcggtgacc actgcaggaa 5461 attagtagag ccccaaatct cagagctcaa ccatcgattt gcagccattt cacacagaat 5521 taagactgga aaggcctcca ttcctttgaa ggaattggag cagtttaact cagatataca 5581 aaaattgctt gaaccactgg aggctgaaat tcagcagggg gtgaatctga aagaggaaga 5641 cttcaataaa gatatgaatg aagacaatga gggtactgta aaagaattgt tgcaaagagg 5701 agacaactta caacaaagaa tcacagatga gagaaagaga gaggaaataa agataaaaca 5761 gcagctgtta cagacaaaac ataatgctct caaggatttg aggtctcaaa gaagaaaaaa 5821 ggctctagaa atttctcatc agtggtatca gtacaagagg caggctgatg atctcctgaa 5881 atgcttggat gacattgaaa aaaaattagc cagcctacct gagcccagag atgaaaggaa 5941 aataaaggaa attgatcggg aattgcagaa gaagaaagag gagctgaatg cagtgcgtag 6001 gcaagctgag ggcttgtctg aggatggggc cgcaatggca gtggagccaa ctcagatcca 6061 gctcagcaag cgctggcggg aaattgagag caaatttgct cagtttcgaa gactcaactt 6121 tgcacaaatt cacactgtcc gtgaagaaac gatgatggtg atgactgaag acatgccttt 6181 ggaaatttct tatgtgcctt ctacttattt gactgaaatc actcatgtct cacaagccct 6241 attagaagtg gaacaacttc tcaatgctcc tgacctctgt gctaaggact ttgaagatct 6301 ctttaagcaa gaggagtctc tgaagaatat aaaagatagt ctacaacaaa gctcaggtcg 6361 gattgacatt attcatagca agaagacagc agcattgcaa agtgcaacgc ctgtggaaag 6421 ggtgaagcta caggaagctc tctcccagct tgatttccaa tgggaaaaag ttaacaaaat 6481 gtacaaggac cgacaagggc gatttgacag atctgttgag aaatggcggc gttttcatta 6541 tgatataaag atatttaatc agtggctaac agaagctgaa cagtttctca gaaagacaca 6601 aattcctgag aattgggaac atgctaaata caaatggtat cttaaggaac tccaggatgg 6661 cattgggcag cggcaaactg ttgtcagaac attgaatgca actggggaag aaataattca 6721 gcaatcctca aaaacagatg ccagtattct acaggaaaaa ttgggaagcc tgaatctgcg 6781 gtggcaggag gtctgcaaac agctgtcaga cagaaaaaag aggctagaag aacaaaagaa 6841 tatcttgtca gaatttcaaa gagatttaaa tgaatttgtt ttatggttgg aggaagcaga 6901 taacattgct agtatcccac ttgaacctgg aaaagagcag caactaaaag aaaagcttga 6961 gcaagtcaag ttactggtgg aagagttgcc cctgcgccag ggaattctca aacaattaaa 7021 tgaaactgga ggacccgtgc ttgtaagtgc tcccataagc ccagaagagc aagataaact 7081 tgaaaataag ctcaagcaga caaatctcca gtggataaag gtttccagag ctttacctga 7141 gaaacaagga gaaattgaag ctcaaataaa agaccttggg cagcttgaaa aaaagcttga 7201 agaccttgaa gagcagttaa atcatctgct gctgtggtta tctcctatta ggaatcagtt 7261 ggaaatttat aaccaaccaa accaagaagg accatttgac gttcaggaaa ctgaaatagc 7321 agttcaagct aaacaaccgg atgtggaaga gattttgtct aaagggcagc atttgtacaa 7381 ggaaaaacca gccactcagc cagtgaagag gaagttagaa gatctgagct ctgagtggaa 7441 ggcggtaaac cgtttacttc aagagctgag ggcaaagcag cctgacctag ctcctggact 7501 gaccactatt ggagcctctc ctactcagac tgttactctg gtgacacaac ctgtggttac 7561 taaggaaact gccatctcca aactagaaat gccatcttcc ttgatgttgg aggtacctgc 7621 tctggcagat ttcaaccggg cttggacaga acttaccgac tggctttctc tgcttgatca 7681 agttataaaa tcacagaggg tgatggtggg tgaccttgag gatatcaacg agatgatcat 7741 caagcagaag gcaacaatgc aggatttgga acagaggcgt ccccagttgg aagaactcat 7801 taccgctgcc caaaatttga aaaacaagac cagcaatcaa gaggctagaa caatcattac 7861 ggatcgaatt gaaagaattc agaatcagtg ggatgaagta caagaacacc ttcagaaccg 7921 gaggcaacag ttgaatgaaa tgttaaagga ttcaacacaa tggctggaag ctaaggaaga 7981 agctgagcag gtcttaggac aggccagagc caagcttgag tcatggaagg agggtcccta 8041 tacagtagat gcaatccaaa agaaaatcac agaaaccaag cagttggcca aagacctccg 8101 ccagtggcag acaaatgtag atgtggcaaa tgacttggcc ctgaaacttc tccgggatta 8161 ttctgcagat gataccagaa aagtccacat gataacagag aatatcaatg cctcttggag 8221 aagcattcat aaaagggtga gtgagcgaga ggctgctttg gaagaaactc atagattact 8281 gcaacagttc cccctggacc tggaaaagtt tcttgcctgg cttacagaag ctgaaacaac 8341 tgccaatgtc ctacaggatg ctacccgtaa ggaaaggctc ctagaagact ccaagggagt 8401 aaaagagctg atgaaacaat ggcaagacct ccaaggtgaa attgaagctc acacagatgt 8461 ttatcacaac ctggatgaaa acagccaaaa aatcctgaga tccctggaag gttccgatga 8521 tgcagtcctg ttacaaagac gtttggataa catgaacttc aagtggagtg aacttcggaa 8581 aaagtctctc aacattaggt cccatttgga agccagttct gaccagtgga agcgtctgca 8641 cctttctctg caggaacttc tggtgtggct acagctgaaa gatgatgaat taagccggca 8701 ggcacctatt ggaggcgact ttccagcagt tcagaagcag aacgatgtac atagggcctt 8761 caagagggaa ttgaaaacta aagaacctgt aatcatgagt actcttgaga ctgtacgaat 8821 atttctgaca gagcagcctt tggaaggact agagaaactc taccaggagc ccagagagct 8881 gcctcctgag gagagagccc agaatgtcac tcggcttcta cgaaagcagg ctgaggaggt 8941 caatactgag tgggaaaaat tgaacctgca ctccgctgac tggcagagaa aaatagatga 9001 gacccttgaa agactccagg aacttcaaga ggccacggat gagctggacc tcaagctgcg 9061 ccaagctgag gtgatcaagg gatcctggca gcccgtgggc gatctcctca ttgactctct 9121 ccaagatcac ctcgagaaag tcaaggcact tcgaggagaa attgcgcctc tgaaagagaa 9181 cgtgagccac gtcaatgacc ttgctcgcca gcttaccact ttgggcattc agctctcacc 9241 gtataacctc agcactctgg aagacctgaa caccagatgg aagcttctgc aggtggccgt 9301 cgaggaccga gtcaggcagc tgcatgaagc ccacagggac tttggtccag catctcagca 9361 ctttctttcc acgtctgtcc agggtccctg ggagagagcc atctcgccaa acaaagtgcc 9421 ctactatatc aaccacgaga ctcaaacaac ttgctgggac catcccaaaa tgacagagct 9481 ctaccagtct ttagctgacc tgaataatgt cagattctca gcttatagga ctgccatgaa 9541 actccgaaga ctgcagaagg ccctttgctt ggatctcttg agcctgtcag ctgcatgtga 9601 tgccttggac cagcacaacc tcaagcaaaa tgaccagccc atggatatcc tgcagattat 9661 taattgtttg accactattt atgaccgcct ggagcaagag cacaacaatt tggtcaacgt 9721 ccctctctgc gtggatatgt gtctgaactg gctgctgaat gtttatgata cgggacgaac 9781 agggaggatc cgtgtcctgt cttttaaaac tggcatcatt tccctgtgta aagcacattt 9841 ggaagacaag tacagatacc ttttcaagca agtggcaagt tcaacaggat tttgtgacca 9901 gcgcaggctg ggcctccttc tgcatgattc tatccaaatt ccaagacagt tgggtgaagt 9961 tgcatccttt gggggcagta acattgagcc aagtgtccgg agctgcttcc aatttgctaa 10021 taataagcca gagatcgaag cggccctctt cctagactgg atgagactgg aaccccagtc 10081 catggtgtgg ctgcccgtcc tgcacagagt ggctgctgca gaaactgcca agcatcaggc 10141 caaatgtaac atctgcaaag agtgtccaat cattggattc aggtacagga gtctaaagca 10201 ctttaattat gacatctgcc aaagctgctt tttttctggt cgagttgcaa aaggccataa 10261 aatgcactat cccatggtgg aatattgcac tccgactaca tcaggagaag atgttcgaga 10321 ctttgccaag gtactaaaaa acaaatttcg aaccaaaagg tattttgcga agcatccccg 10381 aatgggctac ctgccagtgc agactgtctt agagggggac aacatggaaa ctcccgttac 10441 tctgatcaac ttctggccag tagattctgc gcctgcctcg tcccctcagc tttcacacga 10501 tgatactcat tcacgcattg aacattatgc tagcaggcta gcagaaatgg aaaacagcaa 10561 tggatcttat ctaaatgata gcatctctcc taatgagagc atagatgatg aacatttgtt 10621 aatccagcat tactgccaaa gtttgaacca ggactccccc ctgagccagc ctcgtagtcc 10681 tgcccagatc ttgatttcct tagagagtga ggaaagaggg gagctagaga gaatcctagc 10741 agatcttgag gaagaaaaca ggaatctgca agcagaatat gaccgtctaa agcagcagca 10801 cgaacataaa ggcctgtccc cactgccgtc ccctcctgaa atgatgccca cctctcccca 10861 gagtccccgg gatgctgagc tcattgctga ggccaagcta ctgcgtcaac acaaaggccg 10921 cctggaagcc aggatgcaaa tcctggaaga ccacaataaa cagctggagt cacagttaca 10981 caggctaagg cagctgctgg agcaacccca ggcagaggcc aaagtgaatg gcacaacggt 11041 gtcctctcct tctacctctc tacagaggtc cgacagcagt cagcctatgc tgctccgagt 11101 ggttggcagt caaacttcgg actccatggg tgaggaagat cttctcagtc ctccccagga 11161 cacaagcaca gggttagagg aggtgatgga gcaactcaac aactccttcc ctagttcaag 11221 aggaagaaat acccctggaa agccaatgag agaggacaca atgtaggaag tcttttccac 11281 atggcagatg atttgggcag agcgatggag tccttagtat cagtcatgac agatgaagaa 11341 ggagcagaat aaatgtttta caactcctga ttcccgcatg gtttttataa tattcataca 11401 acaaagagga ttagacagta agagtttaca agaaataaat ctatattttt gtgaagggta 11461 gtggtattat actgtagatt tcagtagttt ctaagtctgt tattgttttg ttaacaatgg 11521 caggttttac acgtctatgc aattgtacaa aaaagttata agaaaactac atgtaaaatc 11581 ttgatagcta aataacttgc catttcttta tatggaacgc attttgggtt gtttaaaaat 11641 ttataacagt tataaagaaa gattgtaaac taaagtgtgc tttataaaaa aaagttgttt 11701 ataaaaaccc ctaaaaacaa aacaaacaca cacacacaca catacacaca cacacacaaa 11761 actttgaggc agcgcattgt tttgcatcct tttggcgtga tatccatatg aaattcatgg 11821 ctttttcttt ttttgcatat taaagataag acttcctcta ccaccacacc aaatgactac 11881 tacacactgc tcatttgaga actgtcagct gagtggggca ggcttgagtt ttcatttcat 11941 atatctatat gtctataagt atataaatac tatagttata tagataaaga gatacgaatt 12001 tctatagact gactttttcc attttttaaa tgttcatgtc acatcctaat agaaagaaat 12061 tacttctagt cagtcatcca ggcttacctg cttggtctag aatggatttt tcccggagcc 12121 ggaagccagg aggaaactac accacactaa aacattgtct acagctccag atgtttctca 12181 ttttaaacaa ctttccactg acaacgaaag taaagtaaag tattggattt ttttaaaggg 12241 aacatgtgaa tgaatacaca ggacttatta tatcagagtg agtaatcggt tggttggttg 12301 attgattgat tgattgatac attcagcttc ctgctgctag caatgccacg atttagattt 12361 aatgatgctt cagtggaaat caatcagaag gtattctgac cttgtgaaca tcagaaggta 12421 ttttttaact cccaagcagt agcaggacga tgatagggct ggagggctat ggattcccag 12481 cccatccctg tgaaggagta ggccactctt taagtgaagg attggatgat tgttcataat 12541 acataaagtt ctctgtaatt acaactaaat tattatgccc tcttctcaca gtcaaaagga 12601 actgggtggt ttggtttttg ttgctttttt agatttattg tcccatgtgg gatgagtttt 12661 taaatgccac aagacataat ttaaaataaa taaactttgg gaaaaggtgt aagacagtag 12721 ccccatcaca tttgtgatac tgacaggtat caacccagaa gcccatgaac tgtgtttcca 12781 tcctttgcat ttctctgcga gtagttccac acaggtttgt aagtaagtaa gaaagaaggc 12841 aaattgattc aaatgttaca aaaaaaccct tcttggtgga ttagacaggt taaatatata 12901 aacaaacaaa caaaaattgc tcaaaaaaga ggagaaaagc tcaagaggaa aagctaagga 12961 ctggtaggaa aaagctttac tctttcatgc cattttattt ctttttgatt tttaaatcat 13021 tcattcaata gataccaccg tgtgacctat aattttgcaa atctgttacc tctgacatca 13081 agtgtaatta gcttttggag agtgggctga catcaagtgt aattagcttt tggagagtgg 13141 gttttgtcca ttattaataa ttaattaatt aacatcaaac acggcttctc atgctatttc 13201 tacctcactt tggttttggg gtgttcctga taattgtgca cacctgagtt cacagcttca 13261 ccacttgtcc attgcgttat tttctttttc ctttataatt ctttcttttt ccttcataat 13321 tttcaaaaga aaacccaaag ctctaaggta acaaattacc aaattacatg aagatttggt 13381 ttttgtcttg catttttttc ctttatgtga cgctggacct tttctttacc caaggatttt 13441 taaaactcag atttaaaaca aggggttact ttacatccta ctaagaagtt taagtaagta 13501 agtttcattc taaaatcaga ggtaaataga gtgcataaat aattttgttt taatcttttt 13561 gtttttcttt tagacacatt agctctggag tgagtctgtc ataatatttg aacaaaaatt 13621 gagagcttta ttgctgcatt ttaagcataa ttaatttgga cattatttcg tgttgtgttc 13681 tttataacca ccgagtatta aactgtaaat cataatgtaa ctgaagcata aacatcacat 13741 ggcatgtttt gtcattgttt tcaggtactg agttcttact tgagtatcat aatatattgt 13801 gttttaacac caacactgta acatttacga attatttttt taaacttcag ttttactgca 13861 ttttcacaac atatcagact tcaccaaata tatgccttac tattgtatta tagtactgct 13921 ttactgtgta tctcaataaa gcacgcagtt atgtta //
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