UNSW Embryology
DNA- Tumor Suppressor and Oncogene Database
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Introduction This list was compiled by CGAP Team and represents genes that act as tumour suppressors or oncogenes. This is also a searchable database using the form window below. This page not yet completed Links will not work.
Tumor Suppressor and Oncogene Directory	See original List
This Directory contains genes that are classified as tumor suppressors or oncogenes in the Online Mendelian Inheritance in Man (OMIM) database. For all genes listed, there are links to references in OMIM, sequence data in GenBank, IMAGE clones in UniGene, clone ordering information, and other relevant resources. A gene can be selected from the list below or by entering the gene symbol or gene name in the search window. The records for all genes listed can be downloaded in a choice of file formats. Search: Symbol Description ABL1 v-abl Abelson murine leukemia viral oncogene homolog 1 ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) AKT1 v-akt murine thymoma viral oncogene homolog 1 AKT2 v-akt murine thymoma viral oncogene homolog 2 APC adenomatosis polyposis coli ARAF1 v-raf murine sarcoma 3611 viral oncogene homolog 1 ARHA ras homolog gene family, member A ARHB ras homolog gene family, member B ARHC ras homolog gene family, member C AXL AXL receptor tyrosine kinase BCL2 B-cell CLL/lymphoma 2 BCL3 B-cell CLL/lymphoma 3 BCR breakpoint cluster region BLYM avian lymphoma virus-derived transforming sequence BMI1 murine leukemia viral (bmi-1) oncogene homolog BRAF v-raf murine sarcoma viral oncogene homolog B1 BRCA1 breast cancer 1, early onset BRCA2 breast cancer 2, early onset CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence CCND1 cyclin D1 (PRAD1: parathyroid adenomatosis 1) CDH1 cadherin 1, E-cadherin (epithelial) CDK4 cyclin-dependent kinase 4 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) CHES1 checkpoint suppressor 1 COT cot (cancer Osaka thyroid) oncogene CRK v-crk avian sarcoma virus CT10 oncogene homolog CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like CSF1R colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog D10S170 DNA segment, single copy, probe pH4 (transforming sequence, thyroid-1, DCC deleted in colorectal carcinoma DDX6 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD) E2F1 E2F transcription factor 1 EGFR epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) EIF3S6 eukaryotic translation initiation factor 3, subunit 6 (48kD) ELE1 RET-activating gene ELE1 ELK1 ELK1, member of ETS oncogene family ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) NOTE: Symbol and name provisional. EMP1 epithelial membrane protein 1 EMS1 ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate) EPHA1 EphA1 EPHA3 EphA3 ERBAL2 v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2 ERBB2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) ERBB3 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 ERBB4 v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 ERG v-ets avian erythroblastosis virus E26 oncogene related ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 ETV3 ets variant gene 3 ETV6 ets variant gene 6 (TEL oncogene) EVI1 ecotropic viral integration site 1 EWSR1 Ewing sarcoma breakpoint region 1 FAT FAT tumor suppressor (Drosophila) homolog FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) FES feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog FGF3 fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog) FGF4 fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) FGF6 fibroblast growth factor 6 FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog FKHL1 forkhead (Drosophila)-like 1 FLI1 Friend leukemia virus integration 1 FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) FOS v-fos FBJ murine osteosarcoma viral oncogene homolog FOSL1 FOS-like antigen-1 FOSL2 FOS-like antigen 2 FYN FYN oncogene related to SRC, FGR, YES GLI glioma-associated oncogene homolog (zinc finger protein) GLI2 GLI-Kruppel family member GLI2 GLI3 GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome) GRO1 GRO1 oncogene (melanoma growth stimulating activity, alpha) GRO2 GRO2 oncogene GRO3 GRO3 oncogene HCK hemopoietic cell kinase HKR3 GLI-Kruppel family member HKR3 HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog IRF4 interferon regulatory factor 4 JUN v-jun avian sarcoma virus 17 oncogene homolog JUNB jun B proto-oncogene JUND jun D proto-oncogene KAI1 kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)) KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog KRAS2 v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog LCK lymphocyte-specific protein tyrosine kinase LTA lymphotoxin alpha (TNF superfamily, member 1) LTB lymphotoxin beta (TNF superfamily, member 3) LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog M1S1 membrane component, chromosome 1, surface marker 1 (40kD glycoprotein, identified by monoclonal antibody GA733) M4S1 membrane component, chromosomal 4, surface marker (35kD glycoprotein) MADH4 MAD (mothers against decapentaplegic, Drosophila) homolog 4 MAF v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog MAFG v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein G MAS1 MAS1 oncogene MAX MAX protein MCC mutated in colorectal cancers MCF2 MCF.2 cell line derived transforming sequence MDM2 mouse double minute 2, human homolog of; p53-binding protein MEL mel transforming oncogene (derived from cell line NK14)- RAB8 homolog MEN1 multiple endocrine neoplasia I MET met proto-oncogene (hepatocyte growth factor receptor) MLH1 mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2) MOS v-mos Moloney murine sarcoma viral oncogene homolog MPL myeloproliferative leukemia virus oncogene MSH2 mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1) MYB v-myb avian myeloblastosis viral oncogene homolog MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 MYC v-myc avian myelocytomatosis viral oncogene homolog MYCL1 v-myc avian myelocytomatosis viral oncogene homolog 1, lung carcinoma derived MYCN v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived NBL1 neuroblastoma, suppression of tumorigenicity 1 NF1 neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) NF2 neurofibromin 2 (bilateral acoustic neuroma) NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) NKTR natural killer-tumor recognition sequence NOV nephroblastoma overexpressed gene NRAS neuroblastoma RAS viral (v-ras) oncogene homolog NTRK1 neurotrophic tyrosine kinase, receptor, type 1 PACE paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein) PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) PIM1 pim-1 oncogene PTCH patched (Drosophila) homolog PVT1 pvt-1 (murine) oncogene homolog, MYC activator RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 RALA v-ral simian leukemia viral oncogene homolog A (ras related) RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) RB1 retinoblastoma 1 (including osteosarcoma) REL v-rel avian reticuloendotheliosis viral oncogene homolog RET ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease) ROS1 v-ros avian UR2 sarcoma virus oncogene homolog 1 SKI v-ski avian sarcoma viral oncogene homolog SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 SPINK1 serine protease inhibitor, Kazal type 1 SRC v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog ST5 suppression of tumorigenicity 5 SUPT3H suppressor of Ty (S.cerevisiae) 3 homolog SUPT5H suppressor of Ty (S.cerevisiae) 5 homolog SUPT6H suppressor of Ty (S.cerevisiae) 6 homolog TAL1 T-cell acute lymphocytic leukemia 1 TGFBR2 transforming growth factor, beta receptor II (70-80kD) THPO thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor) THRA thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog) THRB thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2) TIAM1 T-cell lymphoma invasion and metastasis 1 TIM Oncogene TIM TM4SF1 transmembrane 4 superfamily member 1 TNF tumor necrosis factor (TNF superfamily, member 2) TP53 tumor protein p53 (Li-Fraumeni syndrome) TP53BP2 tumor protein p53-binding protein, 2 TP73 tumor protein p73 VAV1 vav 1 oncogene VAV2 vav 2 oncogene VHL von Hippel-Lindau syndrome WNT1 wingless-type MMTV integration site family, member 1 WNT2 wingless-type MMTV integration site family member 2 WNT5A wingless-type MMTV integration site family, member 5A WT1 Wilms tumor 1 YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 Download This Directory: Select local operating system type to download a tab-delimited file containing the information of this directory. For more information on this directory, contact Dr. Lynette Grouse, 301-496-1550. For more information on CGAP, contact Dr. Robert Strausberg , 301-496-1550. If you have comments or questions on this website, contact the NCBI Help Desk.
About Notes These notes from the Embryology Program compiled and written by Dr Mark Hill. This list was originally compiled by CGAP. This Material for Educational Purposes only
m.hill@unsw.edu.au Date Last Modified: 11/3/99 This site maintained by Dr M. Hill